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Latest Amyloid precursor protein Stories

2010-02-25 07:05:00

WASHINGTON, Feb. 25 /PRNewswire/ -- Complementary approaches to Alzheimer's research were recognized as four scientists received the prestigious MetLife Foundation Awards for Medical Research in Alzheimer's Disease in Washington, D.C. during a scientific briefing and luncheon. Todd E. Golde, M.D., Ph.D., professor of neuroscience at the University of Florida and director of its Center for Translational Research in Neurodegenerative Diseases, and Edward H. Koo, M.D., professor of...

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2010-02-08 10:34:32

The benefits of marijuana in tempering or reversing the effects of Alzheimer's disease have been challenged in a new study by researchers at the University of British Columbia and Vancouver Coastal Health Research Institute. The findings, published in the current issue of the journal Current Alzheimer Research, could lower expectations about the benefits of medical marijuana in combating various cognitive diseases and help redirect future research to more promising therapeutics. Previous...

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2010-01-07 08:15:00

Florida Alzheimer's Disease Research Center study in mice indicates long-term exposure to cell phone signals may even boost normal memory The millions of people who spend hours every day on a cell phone may have a new excuse for yakking. A surprising new study in mice provides the first evidence that long-term exposure to electromagnetic waves associated with cell phone use may actually protect against, and even reverse, Alzheimer's disease. The study, led by University of South Florida...

2010-01-04 15:34:28

Inheritance of an extra copy of the gene- ÃŽ² -amyloid precursor protein, APP, in individuals with Down syndrome leads to the inevitable development of early onset Alzheimer's disease, known to be linked to the deposition of Amyloid ÃŽ² peptide or AÃŽ² in the brain. However, a new study published online by Proceedings of the National Academy of Sciences identifies ÃŽ²CTF, a small protein found in APP, as a novel factor for...

2009-12-28 16:43:06

The early stages of Alzheimer's disease are thought to occur at the synapse, since synapse loss is associated with memory dysfunction. Evidence suggests that amyloid beta (AÃŽ²) plays an important role in early synaptic failure, but little has been understood about AÃŽ²'s effect on the plasticity of dendritic spines. These spines are short outgrowths of dendrites (extensions of neurons) that relay electrical impulses in the brain. A single neuron's dendrite...

2009-12-23 16:52:42

Scientists have identified a synergistic interaction that disrupts normal intracellular transport mechanisms and leads to the accumulation of neuron-damaging clumps of protein associated with Parkinson's disease (PD), a neurodegenerative disorder that is characterized by a specific loss of neurons in the midbrain and brainstem. The research, published by Cell Press in the December 24 issue of the journal Neuron, identifies a new potential therapeutic option for preventing PD-associated...

2009-12-16 00:16:33

Although there were promising results in a phase 2 trial, patients with mild Alzheimer disease who received the drug tarenflurbil as part of a phase 3 trial did not have better outcomes on measures of cognitive decline or loss of activities of daily living compared to patients who received placebo, according to a study in the December 16 issue of JAMA. A leading theory on the pathophysiology of Alzheimer disease (AD) is the overproduction of amyloid-ÃŽ²...

2009-12-08 08:00:00

WATERTOWN, Mass., Dec. 8 /PRNewswire/ -- EnVivo Pharmaceuticals today reported the successful reduction in the levels of aggregated Abeta or Beta-Amyloid in an aged transgenic model (Tg2576) of Alzheimer's disease with its lead gamma-secretase modulator (GSM) EVP-0962. The aggregated Abeta, containing predominately oligomeric and larger Abeta fibrillar species, is considered to be the toxic entity in Alzheimer's disease. The reduction of these aggregates further supports the disease...

2009-11-11 17:52:19

A new study reveals that a previously undiscovered mouse gene reduces the two major pathological perturbations commonly associated with Alzheimer's disease (AD). The research, published by Cell Press in the November 12 issue of the journal Neuron, finds that the novel gene interacts with a key cellular enzyme previously linked with AD pathology, thereby uncovering a new strategy for treating this devastating disorder. AD is an incurable neurodegenerative disease characterized by a...

2009-11-10 14:17:13

If taking nonsteroidal antiinflammatory drugs (NSAIDs) such as ibuprofen or naproxen is to protect you from developing Alzheimer disease then you will have to start taking them at a very early age according to research in a mouse model of the disease. Emerging data indicate that an early molecular event in the development of Alzheimer disease is the induction of neuronal cell cycle events (CCEs). While searching for triggers of neuronal CCEs, a team of researchers led by Karl Herrup, at The...


Word of the Day
snash
  • To talk saucily.
  • Insolent, opprobrious language; impertinent abuse.
This word is Scots in origin and probably imitative.