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Latest Amyloid precursor protein Stories

Researchers Discover Gene That Doubles Alzheimer's Risk In African-Americans
2013-04-10 15:39:18

Lawrence LeBlond for redOrbit.com - Your Universe Online Researchers reporting in Tuesday´s issue of JAMA have identified a new gene mutation that nearly doubles the risk of developing Alzheimer´s disease in older blacks. The findings come from the largest genome-wide, government-funded study on Alzheimer´s genes in the African-American community. The mutation found in gene ABCA7 is not the first linked to the cognitive disease but does come as a significant breakthrough...

2013-04-10 10:54:07

New rat model will advance Alzheimer's research A new genetically engineered lab rat that has the full array of brain changes associated with Alzheimer's disease supports the idea that increases in a molecule called beta-amyloid in the brain causes the disease, according to a study, published in the Journal of Neuroscience. The study was supported by the National Institutes of Health. "We believe the rats will be an excellent, stringent pre-clinical model for testing experimental...

2013-03-20 15:45:19

The Journal of Neuroscience has published a study led by researchers at the Max Planck Florida Institute for Neuroscience, the first and only U.S. extension of the prestigious Max Planck Society, that may hold a stunning breakthrough in the fight to treat Alzheimer's disease. The study potentially identifies a cause of Alzheimer's disease–based on a newly-discovered signaling pathway in cellular models of Alzheimer's disease–and opens the door for new treatments by successfully...

2013-03-07 14:40:20

Research illuminates a molecular mechanism for why a stimulating environment may protect against Alzheimer's Disease "Use it or lose it." The saying could apply especially to the brain when it comes to protecting against Alzheimer's disease. Previous studies have shown that keeping the mind active, exercising and social interactions may help delay the onset of dementia in Alzheimer's disease. Now, a new study led by Dennis Selkoe, MD, co-director of the Center for Neurologic Diseases in...

2013-02-20 12:26:27

New findings by Columbia researchers suggest that along with amyloid deposits, white matter hyperintensities (WMHs) may be a second necessary factor for the development of Alzheimer's disease. Most current approaches to Alzheimer's disease focus on the accumulation of amyloid plaque in the brain. The researchers at the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, led by Adam M. Brickman, PhD, assistant professor of neuropsychology, examined the additional...

2012-12-12 12:21:25

A research team composed of University of Kentucky researchers has published a paper which provides the first direct evidence that activated astrocytes could play a harmful role in Alzheimer's disease. The UK Sanders-Brown Center on Aging has also received significant new National Institutes of Health (NIH) funding to further this line of study. Chris Norris, an associate professor in the UK College of Medicine Department of Molecular and Biomedical Pharmacology, as well as a member of the...

Diabetes Drug Treats Alzheimer’s
2012-12-11 19:17:25

Brett Smith for redOrbit.com — Your Universe Online According to a new report in The Journal of Neuroscience, an interdisciplinary team of Japanese and Canadian scientists have shown that a drug intended for diabetes, known as AC253, appears to restore memory in Alzheimer's-affected brain cells. "This is very important because it tells us that drugs like this might be able to restore memory, even after Alzheimer's disease may have set in," said co-author Jack Jhamandas, a...

2012-12-03 20:47:58

Scientists from VIB and KU Leuven have discovered a new target molecule for the development of a treatment against Alzheimer's disease. There is currently no cure for this disease. Many candidate drugs fail because they also target proteins essential to life. This discovery from Leuven could form a target for a treatment against Alzheimer's disease with fewer side effects and that suppresses the very first symptoms of the disease. This research will be published in the leading journal Nature...

2012-11-26 11:23:21

Alzheimer's disease is one of the most common causes of dementia. In Germany and Switzerland alone, around 1.5 million people are affected, and forecasts predict a doubling of the number of patients worldwide within the next 20 years. The accumulation of particular abnormal proteins, including amyloid-ß (Aβ) among others, in patients' brains plays a central role in this disease. Prof. Frank Heppner from the Department of Neuropathology at Charité and his...

2012-10-26 12:51:12

Mouse model may provide clues on mechanism linking diabetes and aging to Alzheimer's Growing evidence suggests that there may be a link between diabetes and Alzheimer's disease, but the physiological mechanisms by which diabetes impacts brain function and cognition are not fully understood. In a new study published in Aging Cell, researchers at the Salk Institute for Biological Studies show, for the first time, that diabetes enhances the development of aging features that may underlie...


Word of the Day
endocarp
  • The hard inner (usually woody) layer of the pericarp of some fruits (as peaches or plums or cherries or olives) that contains the seed.
This word comes from the Greek 'endon,' in, within, plus the Greek 'kardia,' heart.
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