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Latest Amyloid precursor protein Stories

2012-11-26 11:23:21

Alzheimer's disease is one of the most common causes of dementia. In Germany and Switzerland alone, around 1.5 million people are affected, and forecasts predict a doubling of the number of patients worldwide within the next 20 years. The accumulation of particular abnormal proteins, including amyloid-ß (Aβ) among others, in patients' brains plays a central role in this disease. Prof. Frank Heppner from the Department of Neuropathology at Charité and his...

2012-10-26 12:51:12

Mouse model may provide clues on mechanism linking diabetes and aging to Alzheimer's Growing evidence suggests that there may be a link between diabetes and Alzheimer's disease, but the physiological mechanisms by which diabetes impacts brain function and cognition are not fully understood. In a new study published in Aging Cell, researchers at the Salk Institute for Biological Studies show, for the first time, that diabetes enhances the development of aging features that may underlie...

2012-10-22 22:57:07

Researchers at Washington University School of Medicine in St. Louis have found a key difference in the brains of people with Alzheimer's disease and those who are cognitively normal but still have brain plaques that characterize this type of dementia. "There is a very interesting group of people whose thinking and memory are normal, even late in life, yet their brains are full of amyloid beta plaques that appear to be identical to what's seen in Alzheimer's disease," says David L. Brody,...

Cleansing System Inside Brain Drains Waste Products
2012-08-16 12:47:44

Connie K. Ho for redOrbit.com — Your Universe Online Researchers recently discovered a cleansing system in the brain with a new imaging technique. Neuroscientists at the University of Rochester Medical Center found a system that can drain the waste from the brain; it was previously unrecognized by scientists. The system is highly organized and is designed with a series of pipes that depend on the brain´s blood vessels, providing the same function in the brain as the...

2012-08-07 10:02:05

Scientists at the Gladstone Institutes have discovered that an FDA-approved anti-epileptic drug reverses memory loss and alleviates other Alzheimer's-related impairments in an animal model of the disease. Scientists in the laboratory of Lennart Mucke, MD, who directs neurological research at Gladstone, conducted the research on mice genetically modified to simulate key aspects of Alzheimer's disease. In the study, they show how levetiracetam–a drug commonly prescribed for patients...

2012-07-18 10:26:32

CAMBRIDGE, Mass., July 18, 2012 /PRNewswire/ -- Satori Pharmaceuticals, a company dedicated to developing life-changing therapeutics for Alzheimer's disease (AD), announced today that its lead compound, a gamma-secretase modulator (GSM), is efficacious in preclinical models following single or multi-day dosing. This oral presentation, as well as two poster presentations related to the characteristics of Satori's GSMs, was presented at the Alzheimer's Association International Conference...

2012-07-17 06:27:02

Also, Special Session Previews the First Three Prevention Trials in Presymptomatic Alzheimer's VANCOUVER, British Columbia, July 17, 2012 /PRNewswire-USNewswire/ -- The first report of long-term (three-year) stabilization of Alzheimer's disease symptoms with IVIG (Gammagard, Baxter), including no decline on measures of cognition, memory, daily functioning and mood, was reported today at the Alzheimer's Association International Conference® 2012 (AAIC® 2012) in Vancouver. In...

2012-07-17 06:25:37

VANCOUVER, British Columbia, July 17, 2012 /PRNewswire-USNewswire/ -- With FDA approval of a brain amyloid imaging compound in early 2012 and the expected start in 2012 and 2013 of three clinical trials in people with pre-symptomatic Alzheimer's disease, issues around disclosure of dementia risk status are becoming more urgent. Several research efforts reported today at the Alzheimer's Association International Conference® 2012 (AAIC® 2012) describe the creation and evaluation of new...

2012-07-16 10:25:23

VANCOUVER, British Columbia, July 16, 2012 /PRNewswire-USNewswire/ -- Researchers at the Alzheimer's Association International Conference® 2012 (AAIC® 2012) today reported the creation of a new model of Alzheimer's derived from the skin cells of people with the disease that were reprogramed into Alzheimer's brain cells. This new Alzheimer's model may prove to be more accurate than current mouse models of the disease and therefore can be used (a) to generate important new insights...

2012-07-16 06:27:09

VANCOUVER, British Columbia, July 16, 2012 /PRNewswire-USNewswire/ -- Four studies reported today at the Alzheimer's Association International Conference® 2012 (AAIC® 2012) in Vancouver suggest a relationship between sleep quality and quantity and risk of cognitive decline, and that interventions to normalize sleep duration and correct sleep disorders may not only improve quality of life, but have potential to reduce or prevent cognitive decline. "We know that sleep patterns change...