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Latest Amyloid precursor protein Stories

2012-05-22 21:52:09

When brain cells start oozing too much of the amyloid protein that is the hallmark of Alzheimer's disease, the astrocytes that normally nourish and protect them deliver a suicide package instead, researchers report. Amyloid is excreted by all neurons, but rates increase with aging and dramatically accelerate in Alzheimer's. Astrocytes, which deliver blood, oxygen and nutrients to neurons in addition to hauling off some of their garbage, get activated and inflamed by excessive amyloid....

2012-05-16 23:35:32

A well-known genetic risk factor for Alzheimer´s disease triggers a cascade of signaling that ultimately results in leaky blood vessels in the brain, allowing toxic substances to pour into brain tissue in large amounts, scientists report May 16 in the journal Nature. The results come from a team of scientists investigating why a gene called ApoE4 makes people more prone to developing Alzheimer´s. People who carry two copies of the gene have roughly eight to 10 times the risk of...

2012-05-16 22:54:11

Common variants of the ApoE gene are strongly associated with the risk of developing late-onset Alzheimer's disease, but the gene's role in the disease has been unclear. Now, researchers funded by the National Institutes of Health have found that in mice, having the most risky variant of ApoE damages the blood vessels that feed the brain. The researchers found that the high-risk variant, ApoE4, triggers an inflammatory reaction that weakens the blood-brain barrier, a network of cells and...

2012-05-02 21:03:18

A highly toxic beta-amyloid — a protein that exists in the brains of Alzheimer's disease victims — has been found to greatly increase the toxicity of other more common and less toxic beta-amyloids, serving as a possible "trigger" for the advent and development of Alzheimer's, researchers at the University of Virginia and German biotech company Probiodrug have discovered. The finding, reported in the May 2 online edition of the journal Nature, could lead to more effective...

2012-04-27 05:31:18

(Ivanhoe Newswire) -- Alzheimer´s disease (AD) is the leading cause of dementia in the elderly and is an incurable disease that affects more than five million people. Now intravenous human immunoglobulin (IVIG) treatment is currently being explored for uses other than immunotherapy, including AD. Several studies are assessing the tolerability and efficacy of IVIG in Alzheimer´s patients. Recent studies by Dr. Giulio Maria Pasinetti, Saunders Family Chair and Professor in Neurology...

2012-04-24 10:01:08

Without p-tau protein present, impact of amyloid is 'not significantly different from zero' According to a new study, the neuron-killing pathology of Alzheimer's disease (AD), which begins before clinical symptoms appear, requires the presence of both amyloid-beta (a-beta) plaque deposits and elevated levels of an altered protein called p-tau. Without both, progressive clinical decline associated with AD in cognitively healthy older individuals is "not significantly different from...

2012-04-24 09:41:06

Alzheimer's disease (AD) is an incurable, progressive neurodegenerative disease affecting over five million people worldwide, and is the leading cause of dementia in the elderly. Currently, intravenous human immunoglobulin (IVIG) treatment is being explored in multiple off-label uses other than immunotherapy, including AD. Several clinical studies assessing the tolerability and efficacy of IVIG in Alzheimer's disease subjects are in progress with inconsistent outcomes. Recent studies...

2012-04-20 12:42:15

Multiple disease-related changes progress in parallel through distinct stages Studying a mouse model of Alzheimer's disease, neuroscientists at the Technische Universitaet Muenchen have observed correlations between increases in both soluble and plaque-forming beta-amyloid — a protein implicated in the disease process — and dysfunctional developments on several levels: individual cortical neurons, neuronal circuits, sensory cognition, and behavior. Their results, published in...


Word of the Day
bellycheer
  • Good cheer; viands.
  • To revel; to feast.
The word 'bellycheer' may come from 'belle cheer', "good cheer".
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