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Latest Amyloid precursor protein Stories

2012-05-16 22:54:11

Common variants of the ApoE gene are strongly associated with the risk of developing late-onset Alzheimer's disease, but the gene's role in the disease has been unclear. Now, researchers funded by the National Institutes of Health have found that in mice, having the most risky variant of ApoE damages the blood vessels that feed the brain. The researchers found that the high-risk variant, ApoE4, triggers an inflammatory reaction that weakens the blood-brain barrier, a network of cells and...

2012-05-02 21:03:18

A highly toxic beta-amyloid — a protein that exists in the brains of Alzheimer's disease victims — has been found to greatly increase the toxicity of other more common and less toxic beta-amyloids, serving as a possible "trigger" for the advent and development of Alzheimer's, researchers at the University of Virginia and German biotech company Probiodrug have discovered. The finding, reported in the May 2 online edition of the journal Nature, could lead to more effective...

2012-04-27 05:31:18

(Ivanhoe Newswire) -- Alzheimer´s disease (AD) is the leading cause of dementia in the elderly and is an incurable disease that affects more than five million people. Now intravenous human immunoglobulin (IVIG) treatment is currently being explored for uses other than immunotherapy, including AD. Several studies are assessing the tolerability and efficacy of IVIG in Alzheimer´s patients. Recent studies by Dr. Giulio Maria Pasinetti, Saunders Family Chair and Professor in Neurology...

2012-04-24 10:01:08

Without p-tau protein present, impact of amyloid is 'not significantly different from zero' According to a new study, the neuron-killing pathology of Alzheimer's disease (AD), which begins before clinical symptoms appear, requires the presence of both amyloid-beta (a-beta) plaque deposits and elevated levels of an altered protein called p-tau. Without both, progressive clinical decline associated with AD in cognitively healthy older individuals is "not significantly different from...

2012-04-24 09:41:06

Alzheimer's disease (AD) is an incurable, progressive neurodegenerative disease affecting over five million people worldwide, and is the leading cause of dementia in the elderly. Currently, intravenous human immunoglobulin (IVIG) treatment is being explored in multiple off-label uses other than immunotherapy, including AD. Several clinical studies assessing the tolerability and efficacy of IVIG in Alzheimer's disease subjects are in progress with inconsistent outcomes. Recent studies...

2012-04-20 12:42:15

Multiple disease-related changes progress in parallel through distinct stages Studying a mouse model of Alzheimer's disease, neuroscientists at the Technische Universitaet Muenchen have observed correlations between increases in both soluble and plaque-forming beta-amyloid — a protein implicated in the disease process — and dysfunctional developments on several levels: individual cortical neurons, neuronal circuits, sensory cognition, and behavior. Their results, published in...

2012-04-16 23:00:24

Two research studies, co-led by UC Davis neurologist Charles DeCarli and conducted by an international team that included more than 80 scientists at 71 institutions in eight countries, has advanced understanding of the genetic components of Alzheimer´s disease and of brain development. Sacramento, Calif. (PRWEB) April 15, 2012 Two research studies, co-led by UC Davis neurologist Charles DeCarli and conducted by an international team that included more than 80 scientists at 71...

Amazon Now Accepting In-App Payments
2012-04-11 05:53:58

Amazon announced on Tuesday that it will begin accepting in-app payments from its online marketplace. The move is similar to those taken by Google and Apple to generate more revenue by offering in-app updates and upgrades for purchase. Amazon said that it will be taking 30 percent from every in-app purchase made on apps downloaded through the marketplace. “We´re just following the paradigm that´s out there with the 70-30 split,” Amazon App Store´s director...

2012-04-10 13:50:29

According to new study published in the Journal of Alzheimer's Disease Alzheimer's disease (AD) is now the sixth leading cause of death among Americans, affecting nearly 1 in 8 people over the age of 65. There is currently no treatment that alters the course of this disease. However, an increasing amount of evidence suggests that changes in the way the body handles iron and other metals like copper and zinc may start years before the onset of AD symptoms. A new study shows that reducing...


Word of the Day
call-note
  • The call or cry of a bird or other animal to its mate or its young.
'Call-note' is newer than 'bird-call,' which originally referred to 'an instrument for imitating the note of birds' but now also refers to 'the song or cry of a bird.'
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