Quantcast
Last updated on April 18, 2014 at 1:21 EDT

Latest Amyloid precursor protein Stories

2012-03-08 01:03:09

Researchers at the University of California, San Diego, the Medical University of South Carolina, the University of Cincinnati, and American Life Science Pharmaceuticals of San Diego have validated the protease cathepsin B (CatB) as a target for improving memory deficits and reducing the pathology of Alzheimer's disease (AD) in an animal model representative of most AD patients. The study has been published in the online edition of the Journal of Alzheimer's Disease. According to...

2012-03-07 11:15:03

Antibodies that block the process of synapse disintegration in Alzheimer's disease have been identified, raising hopes for a treatment to combat early cognitive decline in the disease. Alzheimer's disease is characterized by abnormal deposits in the brain of the protein Amyloid-ß, which induces the loss of connections between neurons, called synapses. Now, scientists at UCL have discovered that specific antibodies that block the function of a related protein, called Dkk1,...

2012-03-05 06:12:57

(Ivanhoe Newswire)-- With the help of mice, researchers have now found that mitochondria in the brain are dysfunctional early on in Alzheimer's disease, even before memory loss. The team examined mitochondria in three mouse models, each using a different gene shown to cause familial, or early-onset, Alzheimer's disease. The specific mitochondria changes corresponded with the mutation type and included altered mitochondrial movement, structure, and energy dynamics. The changes occurred in...

2012-03-01 11:02:05

Neuroscientists show that HDAC2 enzyme could be a good target for new drugs MIT neuroscientists have shown that an enzyme overproduced in the brains of Alzheimer's patients creates a blockade that shuts off genes necessary to form new memories. Furthermore, by inhibiting that enzyme in mice, the researchers were able to reverse Alzheimer's symptoms. The finding suggests that drugs targeting the enzyme, known as HDAC2, could be a promising new approach to treating the disease, which...

2012-03-01 01:56:53

In a mouse model of Alzheimer's disease, memory problems stem from an overactive enzyme that shuts off genes related to neuron communication, a new study says. When researchers genetically blocked the enzyme, called HDAC2, they 'reawakened' some of the neurons and restored the animals' cognitive function. The results suggest that drugs that inhibit this particular enzyme would make good treatments for some of the most devastating effects of the incurable neurodegenerative disease. "It's...

2012-03-01 01:55:51

NIH-funded research could lead to new therapy A repression of gene activity in the brain appears to be an early event affecting people with Alzheimer's disease, researchers funded by the National Institutes of Health have found. In mouse models of Alzheimer's disease, this epigenetic blockade and its effects on memory were treatable. "These findings provide a glimpse of the brain shutting down the ability to form new memories gene by gene in Alzheimer's disease, and offer hope that we...

2012-02-23 07:00:00

CAMBRIDGE, Mass., Feb. 23, 2012 /PRNewswire/ -- Satori(TM) Pharmaceuticals, a developer of life changing therapeutics for Alzheimer's disease (AD), today announced that it has raised an additional $15 million in financing. Current investors InterWest Partners, New Enterprise Associates Inc. (NEA) and Prospect Venture Partners co-led the round. Prior to this round, Satori had raised a total of $25 million in financing which has allowed the Company to select a group of lead compounds poised for...

2012-02-15 06:41:44

(Ivanhoe Newswire) -- From stress to insomnia to anxiety, whatever the cause may be, new research shows that lack of sleep at night could affect memory later in life. “Disrupted sleep appears to be associated with the build-up of amyloid plaques, a hallmark marker of Alzheimer´s disease, in the brains of people without memory problems. Further research is needed to determine why this is happening and whether sleep changes may predict cognitive decline,” the study author at...

2012-02-14 15:48:00

NEW ORLEANS, Feb. 14, 2012 /PRNewswire-USNewswire/ -- The amount and quality of sleep you get at night may affect your memory later in life, according to research that was released today and will be presented at the American Academy of Neurology's 64th Annual Meeting in New Orleans April 21 to April 28, 2012. "Disrupted sleep appears to be associated with the build-up of amyloid plaques, a hallmark marker of Alzheimer's disease, in the brains of people without memory problems,"...

2012-02-10 15:06:20

“In the last eight days, scientists have delivered a powerful one-two punch in the fight to defeat Alzheimer´s disease,” said Stacy Pagos Haller, President and CEO of the American Health Assistance Foundation (AHAF), a nonprofit that identifies and funds exceptionally high-impact research worldwide through its  Alzheimer´s Disease Research program. “We are excited about today´s announcement by Case Western University researchers that a cancer drug,...