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Last updated on April 16, 2014 at 4:54 EDT

Latest Amyloid Stories

2014-04-14 14:20:45

Alzheimer's disease, the primary cause of dementia in the elderly, imposes a tremendous social and economic burden on modern society. In Japan, the burden of the disease in 2050 is estimated to be a half a trillion US dollars, a figure equivalent to the government's annual revenues. Unfortunately, it has proven very difficult to develop drugs capable of ameliorating the disease. After a tremendous burst of progress in the 1990s, the pace of discoveries has slowed. Dr. Saido believes that...

2014-04-07 11:03:54

Chemists in The College of Arts and Sciences have, for the first time, created enzyme-like activity using peptides that are only seven amino acids long. Their breakthrough, which is the subject of a recent article in Nature Chemistry magazine (Macmillan Publishers, 2014), may revolutionize the study of modern-day enzymes, whose chains of amino acids usually number in the hundreds, and of neurological diseases, such as Alzheimer’s, which are usually characterized by small clumps of...

2014-03-25 08:31:05

--Funds Will Advance Novel Approach for Treatment of Alzheimer's Disease and Other Diseases of Protein Aggregation-- CAMBRIDGE, Mass., March 25, 2014 /PRNewswire/ -- NeuroPhage Pharmaceuticals, Inc. today announced the completion of a $17 million Series D financing from existing and new investors to advance the Company's lead candidate, NPT088, and potential next-generation compounds toward clinical trials. NPT088 has the potential to treat a wide range of neurodegenerative diseases,...

2014-03-05 10:35:00

Stem cells from patients offer model and drug-discovery platform for early-onset form of disease Harvard stem cell scientists have successfully converted skins cells from patients with early-onset Alzheimer's into the types of neurons that are affected by the disease, making it possible for the first time to study this leading form of dementia in living human cells. This may also make it possible to develop therapies far more quickly and accurately than before. The research, led by...

2014-02-20 14:57:31

At 58th Biophysical Society Meeting, researchers from Stanford University try to tease out why a lengthened protein leads to Huntington's disease Proteins are the workhorses of the cell, and their correctly folded three-dimensional structures are critical to cellular functions. Misfolded structures often fail to properly perform these vital jobs, leading to cellular stress and devastating neurodegenerative disorders such as Alzheimer's, Parkinson's and Huntington's disease. In...

Gordon Supercomputer Helps Guide New Drug Designs
2014-02-19 12:45:35

University of California, San Diego Single amyloid-beta monomers can pair up to form a variety of dimers that can aggregate into larger peptide rings that reside on cell membranes such as those pictured. This process has been implicated in the development of Alzheimer’s disease. This visualization shows the possible rings which have the most favorable energies of interactions with the membrane. The residues are colored white to represent apolar or hydrophobic areas, green for the polar...

Unraveling Mysteries Of Amyloid Beta Peptides To Detect And Treat Alzheimer's Disease
2014-02-18 07:41:38

American Institute of Physics Alzheimer's disease has long been marked by progress -- but not the kind of progress the medical community seeks. It is the most common form of dementia among older Americans, and its risk increases with increasing age; for those living with the disease, its ravages get worse over time; and as we move into the 21st century, it will place a greater and greater burden on society. The number of Americans living with Alzheimer's has doubled since 1980 and is...

2014-02-05 23:00:54

Fight Aging  —  Extracellular Aggregates Little Protein Clumps Called Amyloids Released Today by First Class Posting (PRWEB) February 05, 2014 Scientists at the SENS Research Foundation have been working on obliterating unhealthy extracellular aggregates, which is junk that accumulates between cells to cause dysfunction and early death. Also referred to as “amyloids,” these toxic little protein clumps can cause big problems. The human body maintains the structure of the proteins...

2014-01-13 10:21:10

New Study Pinpoints Structural Effects of V44M and V44A Mutations New research, led by Rensselaer Polytechnic Institute researcher Chunyu Wang, has solved one mystery in the development of Familial Alzheimer’s Disease (FAD), a genetic variant of the disease that affects a small fraction of the Alzheimer’s population. In a paper published January 6 in the journal Nature Communications, Wang and his team follow the trail of two genetic mutations – V44M and V44A – known to cause FAD,...

2014-01-13 04:21:08

New Preclinical Results in Non-Human Primates Demonstrate Significant and Sustained Reduction of Transthyretin Using its Proprietary LUNARTM Delivery Technology SAN DIEGO, Jan. 13, 2014 /PRNewswire/ -- Arcturus Therapeutics, Inc., an industry leader in RNA technologies, today announced its flagship program - an RNAi therapeutic targeting transthyretin (TTR)-mediated amyloidosis. Preclinical non-human primate data will be presented at the Biotech Showcase being held January 13, 2014...