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Latest Anaplastic lymphoma kinase Stories

2012-08-13 15:50:34

A broken chromosome is like an unmoored beansprout circling in search of attachment. If a cell tries to replicate itself with broken chromosomes, the cell will be killed and so it would very much like to find its lost end. Often, it finds a workable substitute: another nearby chromosome. When a broken chromosome attaches to another, or when chromosomes use a similar process to exchange genetic material, you have a translocation — genes end up fused to other genes, encoding a new...

2012-07-11 14:47:35

A new drug combination could offer hope to children with neuroblastoma — one of the deadliest forms of childhood cancer — by boosting the effectiveness of a promising new gene-targeted treatment. Researchers at The Institute of Cancer Research in London have found a way to overcome the resistance of cancer cells to a drug called crizotinib, which recently showed positive early results in its first trial in children with cancer. Crizotinib has already been licensed by the US...

2012-05-17 12:14:34

Children's Hospital of Philadelphia researcher leads trial of ALK inhibitor in neuroblastoma, lymphoma A pill designed to zero in on abnormal genes that drive specific cancers has produced encouraging early results in children with an uncommon but aggressive type of lymphoma, as well as in children with a rare form of neuroblastoma. A phase 1 clinical trial of the drug crizotinib achieved remissions, with minimal side effects, for 10 of the children participating in a clinical study...

2012-02-02 18:00:09

Breakthroughs demonstrate importance of targeted therapies Different kinds of lung cancer behave in different ways, suggesting they are fundamentally different diseases. According to a University of Colorado Cancer Center study published in Cancer, the official journal of the American Cancer Society, different subgroups of non-small cell lung cancer (NSCLC) show distinct patterns of spread in the body. The study looked at 209 patients diagnosed with stage IV non-small cell lung cancer...

2012-01-19 13:05:55

Study examines drug resistance in ALK positive lung cancer Scientists from the University of Colorado Cancer Center have once again advanced the treatment of a specific kind of lung cancer. The team has documented how anaplastic lymphoma kinase (ALK) positive advanced non-small cell lung cancer (NSCLC) becomes resistant to a drug targeting the abnormal protein in the cancer. It's the first time scientists have analyzed the frequency and type of drug resistance in ALK positive patients...


Word of the Day
tesla
  • The unit of magnetic flux density in the International System of Units, equal to the magnitude of the magnetic field vector necessary to produce a force of one newton on a charge of one coulomb moving perpendicular to the direction of the magnetic field vector with a velocity of one meter per second. It is equivalent to one weber per square meter.
This word is named for Nikola Tesla, the inventor, engineer, and futurist.