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Last updated on April 20, 2014 at 8:28 EDT

Latest Anti-transglutaminase antibodies Stories

2010-03-01 07:37:01

New research has identified four aspects of immune system disturbance which lead to the development of celiac disease. Nearly 40 different inherited risk factors which predispose to the disease have now been identified. These latest findings could speed the way towards improved diagnostics and treatments for the autoimmune complaint that affects 1 in 100 of the population, and lead to insights into related conditions such as type 1 diabetes. David van Heel, Professor of Gastrointestinal...

2009-10-23 13:35:39

Duodenal biopsy remains the gold standard for celiac disease (CD) diagnosis. However, it has several pitfalls and requires an invasive procedure in children. In the past few years, a more prominent role for a definitive diagnosis based solely on serology has been proposed. The predictive value of high levels of anti-tissue transglutaminase (tTG) antibodies has also been reported in retrospective CD cohorts. Based on these studies, some authors have proposed to start a gluten-free diet (GFD)...

2009-06-23 11:17:49

Iron-deficiency anaemia (IDA) is commonly seen in women aged <50 years. The diagnostic workflow in young women affected by IDA is not clearly established. The British Society of Gastroenterology recommends gastroscopy only in IDA women younger than 45 years presenting with gastrointestinal (GI) symptoms. However, symptoms are often mild and aspecific in IDA women and the gastroscopy is an invasive procedure associated with a high number of refusals. In a previous work on IDA premenopausal...

2008-08-09 03:00:08

By McGowan, Kelly E Lyon, Martha E; Butzner, J Decker BACKGROUND: IgA deficiency causes false-negative IgAbased celiac serology results in patients with celiac disease. Using a case- finding strategy, we examined the prevalence of IgA deficiency, physician evaluation, and management of IgA deficiency during serological testing for celiac disease. METHODS: We reviewed consecutive IgA-endomysial antibody (EMA) and serum IgA results from the laboratory database over 17 months. We...