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Last updated on April 18, 2014 at 1:21 EDT

Latest Antimalarial drug Stories

2012-04-05 21:19:01

Genetics study identifies key genome region underlying artemisinin resistance in malaria parasite Evidence that the most deadly species of malaria parasite, Plasmodium falciparum, is becoming resistant to the front line treatment for malaria on the border of Thailand and Myanmar (Burma) is reported in The Lancet today. This increases concern that resistance could now spread to India and then Africa as resistance to other antimalarial drugs has done before. Eliminating malaria might then...

2012-04-05 21:17:39

Emergence of resistance to the drug artemisinin in western Thailand has created a critical point in global efforts to control and eliminate malaria worldwide, according to a new study published in the Lancet, a British Medical Journal, by researchers at the Texas Biomedical Research Institute and their collaborators in Thailand. A second study, published concurrently in the journal Science by the same research groups, identifies a major region of the malaria parasite genome associated with...

2012-04-02 20:51:06

Malaria infections among infants can be cut by up to 30 per cent when antimalarial drugs are given intermittently over a 12 month period, a three-year clinical trial in Papua New Guinea has shown. The trial showed the drug regime was effective against both Plasmodium falciparum and Plasmodium vivax malaria, the first time antimalarial drugs have been shown to prevent infections by both species of malaria. The treatment regime, called intermittent preventive treatment (IPT), protected the...

2012-03-28 12:11:06

Malaria continues to be a major disease worldwide, but while funding projects are working hard to improve malaria prevention it is difficult to measure how effective these interventions are. New research published in BioMed Central's open access journal Malaria Journal has used a Lives Saved Tool (LiST) model to show that the increase in funding for the prevention of malaria has prevented 850,000 child deaths in the decade between 2001 and 2010 across Africa. According to the WHO, malaria...

2012-03-28 09:32:38

A three-arm randomized trial conducted by Ivo Mueller of the Papua New Guinea Institute of Medical Research, Madang, Papua New Guinea, and colleagues among infants in Papua New Guinea estimates the preventive effect against malaria episodes of intermittent preventive treatment, in an area where children are exposed to both falciparum and vivax malaria. Their findings, published in this week's PLoS Medicine, show that intermittent preventive treatment given during infancy at the time of...

2012-02-28 21:51:51

A chemically altered osteoporosis drug may be useful in fighting malaria, researchers report in a new study. Unlike similar compounds tested against other parasitic protozoa, the drug readily crosses into the red blood cells of malaria-infected mice and kills the malaria parasite. The drug works at very low concentrations with no observed toxicity to the mouse. The researchers found the drug by screening a library of about 1,000 compounds used in previous efforts to target an important...

2012-02-22 10:21:54

In this week's PLoS Medicine, Michael Delves of Imperial College London, UK and colleagues compare the activity of 50 current and experimental antimalarials against liver, sexual blood, and mosquito stages of selected human and nonhuman parasite species, including Plasmodium falciparum, Plasmodium berghei, and Plasmodium yoelii. These results provide a valuable guide to help researchers decide which drugs and compounds show most promise as potential future antimalarial drugs for blocking the...

2012-02-10 10:16:18

A study of almost 3,800 pregnancies has provided the most accurate and direct evidence to date that malaria infection reduces early foetal growth. Low birth weight is the most important risk factor for neonatal mortality in developing countries. The research, carried out on the border of Thailand and Myanmar (Burma), highlights the importance of preventing malaria in pregnancy. According to the World Malaria Report 2011, malaria killed an estimated 655,000 people in 2010. It is caused by...

2012-01-27 12:20:38

New research by scientists at the University of Southampton could lead to the design of more effective drugs to combat malaria. The research will enable scientists to learn more about the nature of the enzymes required for vitamin biosynthesis by the malaria causing pathogen Plasmodium. Vitamins are essential nutrients required in small amounts, the lack of which leads to deficiencies. Many pathogenic microorganisms produce vitamins, and these biosynthetic pathways may provide suitable...