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Last updated on April 18, 2014 at 13:47 EDT

Latest Antimalarial drug Stories

2011-06-15 22:15:48

Malaria is a devastating disease caused by the Plasmodium parasite which is transmitted to humans by infected mosquitoes. Hundreds of millions of new cases of malaria are reported each year, and there are more than 750,000 malaria-related deaths annually. As a result, there is an urgent need for vaccines to combat infection. Now, a new study uncovers a powerful strategy for eliciting an immune response that can combat the parasite during multiple stages of its complex life cycle and describes...

2011-06-01 12:15:00

Press release from PLoS Medicine Reporting the findings of a cluster randomized trial carried out in rural Kenya, Beth Kangwana and colleagues find that provision of packs of the malaria therapy artemether-lumefantrine in shops at a subsidized price more than doubled the proportion of children with fever who received drugs promptly. Importantly, whilst enabling cheap and easy purchase of malaria treatment in shops enabled treatment of about 44% of children with fever, this is still much lower...

2011-06-01 07:48:54

(Ivanhoe Newswire) -- Snug inside a human red blood cell, the malaria parasite hides from the immune system and fuels its growth by digesting hemoglobin, the cell's main protein. The parasite, however, must obtain additional nutrients from the bloodstream via tiny pores in the cell membrane. Now, investigators from the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, have found the genes that malaria parasites use to create these...

2011-05-31 15:34:58

Researchers from the Walter and Eliza Hall Institute have overturned conventional wisdom on how cell movement across all species is controlled, solving the structure of a protein that cuts power to the cell 'motor'. The protein could be a potential drug target for future malaria and anti-cancer treatments. By studying the structure of actin-depolymerising factor 1 (ADF1), a key protein involved in controlling the movement of malaria parasites, the researchers have demonstrated that...

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2011-05-27 11:23:43

NIH researchers show parasites create feeding ion channels in blood cells Snug inside a human red blood cell, the malaria parasite hides from the immune system and fuels its growth by digesting hemoglobin, the cell's main protein. The parasite, however, must obtain additional nutrients from the bloodstream via tiny pores in the cell membrane. Now, investigators from the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, have found the...

2011-05-16 14:24:58

Study will be published in Nature Medicine this Sunday, May 15, and may have impact in the fight against the disease A team of researchers have found that pre-existing malaria prevents secondary infection by another Plasmodium strain, the parasite responsible for malaria, by restricting iron availability in the liver of the host. This discovery will be published this Sunday, May 15, in Nature Medicine and has important implications for the management and prevention of malaria, a condition...

2011-04-22 12:46:17

Using a pair of powerful genome-search techniques, researchers from the Harvard School of Public Health (HSPH), Harvard University, and the Broad Institute have identified several genes that may be implicated in the malaria parasite's notorious ability to rapidly evade drug treatments. Further testing revealed that one of the genes, when inserted into drug-sensitive parasites, rendered them less vulnerable to three antimalarial drugs. The successful experiments suggest that the genomic...

2011-03-31 13:56:19

Speaking at the UK National Stem Cell Network conference in York later today (31 March), Professor Tessa Holyoake from the University of Glasgow will discuss a brand new approach to treating chronic myeloid leukaemia (CML) in which a small number of cancer cells persist despite effective therapy thus preventing cure. CML is a type of blood cancer caused by the infamous "Philadelphia Chromosome" genetic abnormality. It is usually treated using a class of drugs called Tyrosine Kinase Inhibitors...

2011-03-16 14:12:48

Quinine should no longer be the drug of choice for treating severe malaria, according to an updated systematic review by Cochrane researchers. It is now evident that the antimalarial drug artesunate, which is derived from herbs used in Chinese medicine, is more effective at preventing death in patients with severe malaria. Severe malaria occurs when the disease affects the function of vital organs. It is associated with rarer cerebral malaria, which affects the brain and can lead to long-term...

2011-03-15 13:36:29

In the run up to World Malaria Day on the 25th April 2011, BioMed Central's open access journal Malaria Journal takes a long hard look at the development of natural compounds for use in the fight against malaria. There are over 200 million cases of malaria each year with 85% of all cases being children under five years old and, according to the World Health Organisation, in 2009 malaria was responsible for 781,000 deaths worldwide. Low cost treatment is available, 100 million children a year...