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Latest Apicomplexa Stories

Breakthrough In The Battle Against Malaria
2011-11-30 05:54:45

Study identifies new ways to kill the human malaria parasite, Plasmodium falciparum An international team of scientists has announced a breakthrough in the fight against malaria, paving the way for the development of new drugs to treat the deadly disease. According to the World Health Organisation malaria currently infects more than 225 million people worldwide and accounts for nearly 800,000 deaths per year. Most deaths occur among children living in Africa where a child dies every 45...

2011-11-18 03:52:02

New class of compounds would target earliest stages of infection Researchers have discovered a group of chemical compounds that might one day be developed into drugs that can treat malaria infection in both the liver and the bloodstream. The study, which appears in the Nov. 18 issue of Science, was led by Elizabeth A. Winzeler, Ph.D., of the Scripps Research Institute in La Jolla, Calif., and was partially funded by the National Institute of Allergy and Infectious Diseases (NIAID), part of...

2011-11-18 03:34:40

Findings point to the development of novel drugs that could eradicate the disease A international team led by scientists from the Genomics Institute of the Novartis Research Foundation (GNF) and The Scripps Research Institute has discovered a family of chemical compounds that could lead to a new generation of antimalarial drugs capable of not only alleviating symptoms but also preventing the deadly disease. In a study published November 17, 2011, in Science Express, the advance online...

2011-11-18 03:28:21

Data publicly available for global discovery The discovery of a new class of dual-acting antimalarial compounds - the imidazolopiperazines (IZPs) — was published in the journal Science online, at the Science Express website today1. The findings report on compounds that target both liver and blood infections, attacking the Plasmodium parasite at both stages in its reproduction cycle. The findings describe how scientists developed a novel assay to determine liver stage activity of...

2011-11-15 20:57:35

A study conducted by researchers at the Johns Hopkins Malaria Research Institute and their Zambian colleagues detected contrasting patterns of drug resistance in malaria-causing parasites taken from both humans and mosquitoes in rural Zambia. Parasites found in human blood samples showed a high prevalence for pyrimethamine-resistance, which was consistent with the class of drugs widely used to treat malaria in the region. However, parasites taken from mosquitoes themselves had very low...

Malaria Parasite Discovery May Lead To Vaccine
2011-11-10 14:08:10

[ Watch the Video ] Researchers have revealed a new discovery in understanding how a malaria parasite invades human red blood cells. The team from the Wellcome Trust Sanger Institute said they found that the parasite relies on a single receptor on the red blood cell's surface to invade. Malaria kills about a million people every year, most of them being children in Africa under the age of five. The blood stage of the parasite's lifecycle starts when it invades human red blood...

2011-11-09 10:05:25

For some time now, artemisinin, derived from a Chinese herb, has been the most powerful treatment available against malaria. To avoid the malaria parasite becoming resistant, the World Health Organisation (WHO) strongly recommends combining artemisinin with another anti-malarial drug. But there are different formulations and derivatives, in different combinations and with dosing schemes. Scientists from the Institute of Tropical Medicine (ITM) carried out a head-to-head comparison of four...

2011-11-09 09:59:16

A large study from Africa, published in this week's PLoS Medicine, has found that in a direct comparison, three types of new, fast-acting antimalarial artemisinin-based combination therapy drugs (ACTs), which comprise artemisinin derivatives in combination with a partner antimalarial drug, AL (artesunate—mefloquine), ASAQ (artesunate—amodiaquine) and DHAPQ (dihydroartemisinin—piperaquine) are all effective for treating children with uncomplicated malaria. In a randomized...


Word of the Day
sough
  • A murmuring sound; a rushing or whistling sound, like that of the wind; a deep sigh.
  • A gentle breeze; a waft; a breath.
  • Any rumor that engages general attention.
  • A cant or whining mode of speaking, especially in preaching or praying; the chant or recitative characteristic of the old Presbyterians in Scotland.
  • To make a rushing, whistling, or sighing sound; emit a hollow murmur; murmur or sigh like the wind.
  • To breathe in or as in sleep.
  • To utter in a whining or monotonous tone.
According to the OED, from the 16th century, this word is 'almost exclusively Scots and northern dialect until adopted in general literary use in the 19th.'
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