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Last updated on April 16, 2014 at 17:34 EDT

Latest Apolipoprotein E Stories

2009-07-14 06:08:00

BROOMFIELD, Colo., July 14 /PRNewswire/ -- Accera, Inc., a biotechnology company delivering breakthrough therapies in central nervous system diseases, today announced further evidence for genetic interactions impacting the efficacy of the ketogenic compound AC-1202 (Axona(TM)) in Alzheimer's disease. New data from the company's previously completed double-blind, placebo-controlled trial in patients with mild-to-moderate Alzheimer's disease demonstrates an interaction between two genetic...

2009-04-09 14:01:32

British researchers suggest brain activity already present in young people may be associated later with Alzheimer's disease. The study, published in the Proceedings of the National Academy of Sciences, may be a step towards a diagnostic test to identify individuals at risk for Alzheimer's. The Oxford University and Imperial College London researchers used functional magnetic resonance imaging to compare activity inside the brains of 36 volunteers aged between 20 and 35 years -- 18 carrying at...

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2009-04-07 11:21:59

Researchers have discovered that brain activity changes in young adulthood may serve as a reliable warning sign for developing dementia in the future. Scientists from the University of Oxford and Imperial College London used brain imaging to find clues as to why certain people develop Alzheimer's Disease. Previous studies have shown that the gene called ApoE4 increased the risk of Alzheimer's in patients, but researchers in the new study found that the mutation also accounted for heightened...

2009-01-16 10:29:25

Amsterdam, The Netherlands and Sun City, AZ, USA, January 15, 2009 "“ Researchers at Banner Health's Sun Health Research Institute have uncovered evidence that Alzheimer's disease (AD) may be clinically confirmed in patients with apolipoprotein E2 homozygote. The results of their study are published in the January 2009 issue of the Journal of Alzheimer's Disease.Apolipoprotein E2 homozygote has been associated with a protective effect against AD and contributes to delaying the onset of...

2009-01-12 09:21:02

Researchers at Mayo Clinic have discovered the first gender-linked susceptibility gene for late-onset Alzheimer's disease. In the Jan. 11 online edition of Nature Genetics, they report the results of their two-stage genome-wide association study of patients with Alzheimer's disease. The research showed that women who inherited two copies of a variant in the PCDH11X gene, found on the X chromosome, are at considerably greater risk of developing Alzheimer's disease. Women with a variant on one...

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2009-01-01 13:42:15

Scientists have new information about the complex genetic signature associated with Alzheimer's disease, the leading cause of cognitive decline and dementia in the elderly. The research, published by Cell Press in the January issue of the American Journal of Human Genetics, uses a powerful, high-resolution analysis to look for genes associated with this devastating neurodegenerative disorder. Previous research linked late-onset Alzheimer's disease, the most common form, with the...

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2008-11-30 07:20:00

A Swedish researcher said on Friday that mice who were fed junk food for nine months showed signs of developing the abnormal brain tangles strongly associated with Alzheimer's disease. A series of published papers by a researcher at Sweden's Karolinska Institute showed how a diet rich in fat, sugar and cholesterol could increase the risk of the most common type of dementia. "On examining the brains of these mice, we found a chemical change not unlike that found in the Alzheimer brain,"...

2008-08-20 09:00:22

SAN FRANCISCO, Aug. 20 /PRNewswire/ -- Emerging therapeutic strategies for Alzheimer's disease is the focus of the most recent edition of Neurotech Insights, the leading monthly industry newsletter covering drugs, devices and diagnostics for the brain and nervous system. This month's feature article reviews the competing hypotheses around the cause of Alzheimer's disease including: the beta amyloid theory, tau hypothesis, the APOE4 and vascular theory, anti-inflammatories, memory...

2008-07-30 21:00:36

CHICAGO _ Middle-aged married people who worry a lot have at least one thing to look forward to: Their risk of eventually developing Alzheimer's disease may be significantly less than carefree people of the same age who remain single. That's the take-home message from two studies presented jointly Wednesday in Chicago at the International Conference on Alzheimer's Disease. One study followed 1,449 men and women in Finland for an average of 21 years. It found that those who had a partner...

2008-07-29 18:00:20

Elan Corporation, plc (NYSE: ELN) and Wyeth (NYSE: WYE) today are presenting detailed results from the companies' 18-month Phase 2 study of bapineuzumab (AAB-001) in patients with mild to moderate Alzheimer's disease at the Alzheimer's Association's International Conference on Alzheimer's Disease 2008 in Chicago, Illinois. As previously announced, in the study, bapineuzumab appeared to have an acceptable safety profile and clinical activity in treating Alzheimer's disease. Potential efficacy...