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Latest Apolipoprotein E Stories

Pfizer Drug Study Falls Short For Alzheimer’s
2012-07-24 08:50:54

Lawrence LeBlond for redOrbit.com - Your Universe Online In one of two late-stage trials conducted by Pfizer, an experimental Alzheimer´s drug failed to slow the disease´s progress, but the pharma said on Monday that it will continue to study the drug´s effect on the other group. The injected drug bapineuzumab, being tested through a partnership with Johnson & Johnson, didn´t slow mental or functional decline in patients with mild or moderate Alzheimer´s...

2012-05-16 23:35:32

A well-known genetic risk factor for Alzheimer´s disease triggers a cascade of signaling that ultimately results in leaky blood vessels in the brain, allowing toxic substances to pour into brain tissue in large amounts, scientists report May 16 in the journal Nature. The results come from a team of scientists investigating why a gene called ApoE4 makes people more prone to developing Alzheimer´s. People who carry two copies of the gene have roughly eight to 10 times the risk of...

2012-05-16 22:54:11

Common variants of the ApoE gene are strongly associated with the risk of developing late-onset Alzheimer's disease, but the gene's role in the disease has been unclear. Now, researchers funded by the National Institutes of Health have found that in mice, having the most risky variant of ApoE damages the blood vessels that feed the brain. The researchers found that the high-risk variant, ApoE4, triggers an inflammatory reaction that weakens the blood-brain barrier, a network of cells and...

2012-05-09 21:32:20

Efforts to understand how the aging process affects the brain and cognition have expanded beyond simply comparing younger and older adults. "Everybody ages differently. By looking at genetic variations and individual differences in markers of vascular health, we begin to understand that preventable factors may affect our chances for successful aging," said Wayne State University psychology doctoral student Andrew Bender, lead author of a study supported by the National Institute on Aging...

2012-04-04 11:01:20

Discovery challenges current thinking and points to new therapies Scientists at the Gladstone Institutes have enhanced our understanding of how a protein linked to Alzheimer's disease keeps young brains healthy, but can damage them later in life–suggesting new research avenues for treating this devastating disease. In the Journal of Neuroscience, available online today, researchers in the laboratory of Yadong Huang, MD, PhD, have uncovered the distinct roles that the apoE protein...


Word of the Day
grass-comber
  • A landsman who is making his first voyage at sea; a novice who enters naval service from rural life.
According to the OED, a grass-comber is also 'a sailor's term for one who has been a farm-labourer.'