Latest Apolipoprotein E Stories
In one of two late-stage trials conducted by Pfizer, an experimental Alzheimer’s drug failed to slow the disease’s progress, but the pharma said on Monday that it will continue to study the drug’s effect on the other group.
A well-known genetic risk factor for Alzheimer’s disease triggers a cascade of signaling that ultimately results in leaky blood vessels in the brain, allowing toxic substances to pour into brain tissue in large amounts.
Common variants of the ApoE gene are strongly associated with the risk of developing late-onset Alzheimer's disease, but the gene's role in the disease has been unclear.
Efforts to understand how the aging process affects the brain and cognition have expanded beyond simply comparing younger and older adults.
Scientists at the Gladstone Institutes have enhanced our understanding of how a protein linked to Alzheimer's disease keeps young brains healthy, but can damage them later in life—suggesting new research avenues for treating this devastating disease.
- totally perplexed and mixed up.