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Last updated on April 16, 2014 at 8:29 EDT

Latest Apolipoprotein E Stories

2010-04-14 13:21:00

PHOENIX, April 14 /PRNewswire/ -- A brain-imaging study published today in the Archives of Neurology suggests that a major genetic risk factor for Alzheimer's disease in the Anglo population is also a risk factor for the disease in Latinos. While a gene called APOE4 has been firmly established to increase an Anglo person's risk of Alzheimer's disease, its relationship to the disease in different Latino populations has been less clear. In previous studies, researchers from the Banner...

2010-03-15 15:40:00

JACKSONVILLE, Fla. "” Using sophisticated techniques that scan the genomes of patients, researchers at the Mayo Clinic campus in Florida have found that a gene appears to either help protect against development of Alzheimer's disease, or promote the disorder depending on the level of gene in the brain. In two research studies published almost simultaneously in the journals Neurology and PLoS ONE, the scientists found strong evidence for the role of the gene, insulin-degrading enzyme...

2010-03-09 10:02:00

THESSALONIKI, Macedonia, Greece, March 9 /PRNewswire/ -- Accera, Inc., a biotechnology company delivering breakthrough therapies in central nervous system diseases, announced data which showed that augmentation with ketone bodies significantly improved cognitive function in Alzheimer's disease (AD) patients. An early feature of AD is region specific declines in cerebral glucose metabolism. One strategy has been to supplement the brain's normal glucose supply with ketone bodies. The...

2010-02-17 09:55:32

Researchers at Universitat Autònoma de Barcelona (UAB) and University of Stockholm have created a computer modeling of the structural malfunctioning of the ApoE4 protein when it enters into contact with the Amyloid beta molecule, the main cause of Alzheimer's disease. The research, published in PLoS Computational Biology, supports experimental evidence that links ApoE4 with this pathology and opens up new exploration possibilities in understanding and fighting against the...

2010-01-26 13:51:37

Genetic adaption to meat-rich diets may also lead to high rates of Alzheimer's and heart disease The same evolutionary genetic advantages that have helped increase human lifespans also make us uniquely susceptible to diseases of aging such as cancer, heart disease and dementia, reveals a study to be published in a special PNAS collection on "Evolution in Health and Medicine" on Tuesday, Jan. 26. Comparing the life spans of humans with other primates, Caleb Finch, ARCO & William F....

2009-12-09 19:41:51

The low-density lipoprotein receptor (LDLR) has received a lot of attention because of its connection with coronary heart disease and atherosclerosis, but now it appears as if it may have a beneficial influence in degenerative brain diseases. New research, published by Cell Press in the December 10th issue of the journal Neuron, links LDLR with a reduction in brain changes associated with Alzheimer's disease (AD) and suggests a new therapeutic strategy for this incurable disease. Amyloid...

2009-12-03 21:19:52

Reversing abnormal brain activity in Alzheimer models improves development of new nerve cells born in adult brains Stimulating the growth of new neurons to replace those lost in Alzheimer's disease (AD) is an intriguing therapeutic possibility. But will the factors that cause AD allow the new neurons to thrive and function normally? Scientists at the Gladstone Institute of Neurological Disease (GIND) have discovered that two main causes of AD amyloid-beta (AÃŽ²) peptides and...

2009-12-02 18:57:41

Human genes have adapted to inflammation, but we are more susceptible to diseases of aging In spite of their genetic similarity to humans, chimpanzees and great apes have maximum lifespans that rarely exceed 50 years. The difference, explains USC Davis School of Gerontology Professor Caleb Finch, is that as humans evolved genes that enabled them to better adjust to levels of infection and inflammation and to the high cholesterol levels of their meat rich diets. In the December issue of PNAS...

2009-11-17 14:16:10

Brain imaging can offer a window into risk for diseases such as Alzheimer's disease (AD). A study conducted at the University of Kansas School of Medicine demonstrated that genetic risk is expressed in the brains of even those who are healthy, but carry some risk for AD. The results of this study are published in the November 2009 issue of the Journal of Alzheimer's Disease. Investigators used automated neuroimaging analysis techniques to characterize the impact of an AD-risk gene,...

2009-11-13 15:51:00

NORTH CHICAGO, Ill., Nov. 13 /PRNewswire-USNewswire/ -- Research that is targeting the early diagnosis of Alzheimer disease has drawn national attention to the work of Michael Seidenberg, PhD, a faculty member at Rosalind Franklin University of Medicine and Science. Dr. Seidenberg, a professor in the university's Department of Psychology, is the lead author of an article in the journal Neurology detailing a study that maps the brain activity of 69 healthy senior men and women, aged 65-85,...