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Latest Apolipoprotein E Stories

2010-06-15 14:29:25

By investigating the association between genetic loci related to Alzheimer's disease and neuroimaging measures related to disease risk, researchers may have uncovered additional evidence that several previously studied genetic variants are associated with the development and progression of Alzheimer's disease and also may have identified new genetic risk factors for further study, according to a report in the June issue of Archives of Neurology, one of the JAMA/Archives journals. "The...

2010-06-15 01:10:39

A molecule implicated in Alzheimer's disease interferes with brain cells by making them unable to "recycle" the surface receptors that respond to incoming signals, researchers at UT Southwestern Medical Center have found. The harmful molecule, called APOE4, is present in about one out of every six people, the researchers said. Those with the gene for APOE4 have up to 10 times the risk of developing Alzheimer's disease earlier in life than average. The researchers discovered that APOE4 makes a...

2010-05-18 11:45:56

APOEe-4 gene carriers with Alzheimer's disease have more memory problems; non-carriers troubled with attention, language and executive function In the most comprehensive study to date, neurologists have clearly identified significant differences in the ways that Alzheimer's disease (AD) affects patients with and without the apolipoprotein E ÃŽµ4 gene (APOE ÃŽµ4), a known genetic risk factor for the neurodegenerative disease, using a combination of cognitive...

2010-05-12 08:04:45

Although genome-wide analysis identified two genetic variations associated with Alzheimer disease (AD), these variations did not improve the ability to predict the risk of AD, according to a study in the May 12 issue of JAMA. "One of every 5 persons aged 65 years is predicted to develop AD in their lifetime, and genetic variants may play an important part in the development of the disease. The apparent substantial heritability of late-onset AD is inadequately explained by genetic variation...

2010-04-21 17:46:00

HOUSTON, April 21 /PRNewswire/ -- Effective immediately, SpectraCell Laboratories now offers apolipoprotein E genotyping. This test determines a person's genetic risk for heart disease associated with the commonly studied gene called apoE, which is involved in the metabolism of cholesterol and triglycerides (fats in the blood). The medical community generally agrees that heart disease risk is affected by both environmental and genetic factors. ApoE is a protein that affects how...

2010-04-14 13:21:00

PHOENIX, April 14 /PRNewswire/ -- A brain-imaging study published today in the Archives of Neurology suggests that a major genetic risk factor for Alzheimer's disease in the Anglo population is also a risk factor for the disease in Latinos. While a gene called APOE4 has been firmly established to increase an Anglo person's risk of Alzheimer's disease, its relationship to the disease in different Latino populations has been less clear. In previous studies, researchers from the Banner...

2010-03-15 15:40:00

JACKSONVILLE, Fla. "” Using sophisticated techniques that scan the genomes of patients, researchers at the Mayo Clinic campus in Florida have found that a gene appears to either help protect against development of Alzheimer's disease, or promote the disorder depending on the level of gene in the brain. In two research studies published almost simultaneously in the journals Neurology and PLoS ONE, the scientists found strong evidence for the role of the gene, insulin-degrading enzyme...

2010-03-09 10:02:00

THESSALONIKI, Macedonia, Greece, March 9 /PRNewswire/ -- Accera, Inc., a biotechnology company delivering breakthrough therapies in central nervous system diseases, announced data which showed that augmentation with ketone bodies significantly improved cognitive function in Alzheimer's disease (AD) patients. An early feature of AD is region specific declines in cerebral glucose metabolism. One strategy has been to supplement the brain's normal glucose supply with ketone bodies. The...

2010-02-17 09:55:32

Researchers at Universitat Autònoma de Barcelona (UAB) and University of Stockholm have created a computer modeling of the structural malfunctioning of the ApoE4 protein when it enters into contact with the Amyloid beta molecule, the main cause of Alzheimer's disease. The research, published in PLoS Computational Biology, supports experimental evidence that links ApoE4 with this pathology and opens up new exploration possibilities in understanding and fighting against the...

2010-01-26 13:51:37

Genetic adaption to meat-rich diets may also lead to high rates of Alzheimer's and heart disease The same evolutionary genetic advantages that have helped increase human lifespans also make us uniquely susceptible to diseases of aging such as cancer, heart disease and dementia, reveals a study to be published in a special PNAS collection on "Evolution in Health and Medicine" on Tuesday, Jan. 26. Comparing the life spans of humans with other primates, Caleb Finch, ARCO & William F....


Word of the Day
bibliopole
  • A bookseller; now, especially, a dealer in rare and curious books.
This word comes from a Greek phrase meaning 'book seller.'
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