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Latest Apolipoprotein E Stories

2010-01-26 13:51:37

Genetic adaption to meat-rich diets may also lead to high rates of Alzheimer's and heart disease The same evolutionary genetic advantages that have helped increase human lifespans also make us uniquely susceptible to diseases of aging such as cancer, heart disease and dementia, reveals a study to be published in a special PNAS collection on "Evolution in Health and Medicine" on Tuesday, Jan. 26. Comparing the life spans of humans with other primates, Caleb Finch, ARCO & William F....

2009-12-09 19:41:51

The low-density lipoprotein receptor (LDLR) has received a lot of attention because of its connection with coronary heart disease and atherosclerosis, but now it appears as if it may have a beneficial influence in degenerative brain diseases. New research, published by Cell Press in the December 10th issue of the journal Neuron, links LDLR with a reduction in brain changes associated with Alzheimer's disease (AD) and suggests a new therapeutic strategy for this incurable disease. Amyloid...

2009-12-03 21:19:52

Reversing abnormal brain activity in Alzheimer models improves development of new nerve cells born in adult brains Stimulating the growth of new neurons to replace those lost in Alzheimer's disease (AD) is an intriguing therapeutic possibility. But will the factors that cause AD allow the new neurons to thrive and function normally? Scientists at the Gladstone Institute of Neurological Disease (GIND) have discovered that two main causes of AD amyloid-beta (AÃŽ²) peptides and...

2009-12-02 18:57:41

Human genes have adapted to inflammation, but we are more susceptible to diseases of aging In spite of their genetic similarity to humans, chimpanzees and great apes have maximum lifespans that rarely exceed 50 years. The difference, explains USC Davis School of Gerontology Professor Caleb Finch, is that as humans evolved genes that enabled them to better adjust to levels of infection and inflammation and to the high cholesterol levels of their meat rich diets. In the December issue of PNAS...

2009-11-17 14:16:10

Brain imaging can offer a window into risk for diseases such as Alzheimer's disease (AD). A study conducted at the University of Kansas School of Medicine demonstrated that genetic risk is expressed in the brains of even those who are healthy, but carry some risk for AD. The results of this study are published in the November 2009 issue of the Journal of Alzheimer's Disease. Investigators used automated neuroimaging analysis techniques to characterize the impact of an AD-risk gene,...

2009-11-13 15:51:00

NORTH CHICAGO, Ill., Nov. 13 /PRNewswire-USNewswire/ -- Research that is targeting the early diagnosis of Alzheimer disease has drawn national attention to the work of Michael Seidenberg, PhD, a faculty member at Rosalind Franklin University of Medicine and Science. Dr. Seidenberg, a professor in the university's Department of Psychology, is the lead author of an article in the journal Neurology detailing a study that maps the brain activity of 69 healthy senior men and women, aged 65-85,...

2009-10-20 07:00:00

ST. LOUIS, Oct. 20 /PRNewswire-FirstCall/ -- Sigma-Aldrich® (Nasdaq: SIAL) today announced the launch of the SAGE(TM) Priority Partners Program, through which the Company plans to build a network of researchers to evaluate the 'knockout' rat models it is developing to support pre-clinical research work across a number of medical fields, including Neurobiology, Toxicology, Cardiology, Immunology and others. The partner program, managed by Sigma Advanced Genetic...

2009-10-06 14:27:11

The action of a small protein that is a major villain in Alzheimer's disease can be counterbalanced with another brain protein, researchers at UT Southwestern Medical Center have found in an animal study. The findings, available online in the journal Proceedings of the National Academy of Sciences, suggest a promising new tactic against the devastating illness, the researchers said. The harmful protein, called beta-amyloid, is found in the brain and, when functioning properly, suppresses...

2009-09-08 14:12:57

An international team of scientists led by Cardiff University in Wales has reported finding two more genetic risk factors of Alzheimer's disease. The group said it completed the largest genome-wide association study ever involving patients with Alzheimer's disease. The study pooled DNA samples from more than 19,000 older European and U.S. residents. The researchers said previously only four genes had been definitively associated with Alzheimer's disease -- three genetic mutations identified...

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2009-09-07 06:45:00

An international team of scientists has identified two more genetic risk factors for Alzheimer's disease. The findings are reported in the online edition of the journal Nature Genetics. The group, led by investigators from the School of Medicine at Cardiff in the United Kingdom and including scientists from Washington University School of Medicine in St. Louis, completed the largest genome-wide association study ever involving patients with Alzheimer's disease. The study pooled DNA samples...


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blee
  • Color; hue; complexion.
This word is Middle English in origin.
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