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Latest Apoptosis Stories

2012-07-17 15:15:44

Researchers from the Hebrew University of Jerusalem and the Weizmann Institute of Science have developed a technique to cause apoptosis, or programmed cell death, that could lead to new approaches to treating cancer. Apoptosis is an essential defense mechanism against the spread of abnormal cells such as cancer. It is a complex process that occurs through networks of proteins that interact with each other. Cancer cells usually avoid this process due to mutations in the genes that encode...

2012-07-10 10:48:44

Cylene and Peter Mac findings establish activation of p53 by targeting Pol I with CX-5461 selectively kills cancer Cylene Pharmaceuticals today announced that research collaborators at the Peter MacCallum Cancer Centre (Peter Mac) in Melbourne, Australia have established, for the first time, that RNA Polymerase I (Pol I) activity is essential for cancer cell survival and that its inhibition selectively activates p53 to kill tumors. Published today in Cancer Cell, the findings show that...

2012-07-09 17:30:09

This approach is described in the work published today in the Journal of Clinical Investigation, which sheds light on the mechanisms that regulate squamous cell carcinoma development Skin squamous cell carcinoma (SCC) is a subtype of very aggressive skin cancers that usually develops in sunexposed body regions, but can also affect a large number of organs such as the bladder, esophagus, lungs etc. However, little is known about the biology of these cells, which consequently makes difficult...

2012-07-02 21:42:17

Researchers at Georgetown Lombardi Comprehensive Cancer Center have uncovered a single molecule they say is a major determinant of resistance to anti-estrogen therapy used to treat or prevent breast cancer in high-risk women. In the July 1 issue of Cancer Research, the scientists say glucose-regulated protein 78 (GRP78), activated as breast cells undergo stress induced by the agents tamoxifen and fulvestrant, turns off apoptosis, a cell death response, and turns on autophagy. In autophagy,...

2012-07-02 06:07:17

(Ivanhoe Newswire) — Researchers have discovered a single molecule that they say is a major cause of resistance to anti-estrogen therapy used to prevent or treat breast cancer in high-risk women. The researchers say glucose-regulated protein 78 (GRP78), which is triggered as breast cells become stressed from the agents tamoxifen and fulvestrant, turns off apoptosis (a cell death response) and turns on autophagy. Autophagy occurs when the cell "eats" and digests components within the...

2012-06-25 23:10:34

Prions, the causal agents of Mad Cow and other diseases, are very unique infectious particles. They are proteins in which the complex molecular three-dimensional folding process just went astray. For reasons not yet understood, the misfolding nature of prions is associated to their ability to sequester their normal counterparts and induce them to also adopt a misfolding conformation. The ever-growing crowd of misfolded proteins form the aggregates seen in diseases such as Parkinson's and...

2012-06-15 14:27:18

An unexpected discovery of how the body controls cell death has revealed a potential new therapeutic target. A research team based at Cardiff University's School of Biosciences has already revealed the mechanism by which high alcohol intake can induce pancreatitis and its progression to pancreatic cancer. Now a new study, published in Current Biology, reveals a hitherto unknown interaction between two well known molecules, which has important implications for our understanding of...

2012-06-11 21:37:06

Mutated tumor suppressor gene p53 leads to better results Presence of normal p53, a tumor suppressor gene, instead of a mutated version, makes breast cancer chemotherapy with doxorubicin less effective. The preclinical study led by MD Anderson scientists was published today in the journal Cancer Cell. The research, which challenges the existing paradigm, is another step closer to personalized cancer medicine for breast cancer. "It's really important to understand the genetic defects...


Word of the Day
siliqua
  • A Roman unit of weight, 1⁄1728 of a pound.
  • A weight of four grains used in weighing gold and precious stones; a carat.
  • In anatomy, a formation suggesting a husk or pod.
  • The lowest unit in the Roman coinage, the twenty-fourth part of a solidus.
  • A coin of base silver of the Gothic and Lombard kings of Italy.
'Siliqua' comes from a Latin word meaning 'a pod.'
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