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Latest Apoptosis Stories

2012-01-23 22:03:46

Could preventing colon cancer be as simple as developing a taste for yerba mate tea? In a recent University of Illinois study, scientists showed that human colon cancer cells die when they are exposed to the approximate number of bioactive compounds present in one cup of this brew, which has long been consumed in South America for its medicinal properties. "The caffeine derivatives in mate tea not only induced death in human colon cancer cells, they also reduced important markers of...

2012-01-21 00:11:46

The expression of p53 and Mdm2 is closely related. In an article published this week in the Cancel Cell review, Robin Fahraeus and his collaborators from Inserm Unit 940 ("Therapeutic Targets for Cancer"), demonstrate that cellular response to DNA damage requires involvement from the protein kinase ATM so that Mdm2 can positively or negatively control protein p53. Much focus is placed on protein p53 in cancer research. Discovered in 1979, p53 precisely regulates cell proliferation and...

2012-01-19 14:49:10

Cholesterol-lowering statins seem to keep breast cancer at bay in some patients. Now researchers reporting in the January 20th issue of the journal Cell, a Cell Press publication, provide clues about how statins might yield those unexpected benefits. The findings also suggest that mutations in a single gene could be used to identify tumors likely to respond to statin therapy. "The data raises the possibility that we might identify subsets of patients whose tumors may respond to statins,"...

2012-01-12 12:18:26

Interferon-stimulated gene 15 (ISG15), a ubiquitin like protein, is highly elevated in a variety of cancers including breast cancer. How the elevated ISG15 pathway contributes to tumorigenic phenotypes remains unclear and is the subject of a study published in the January 2012 issue of Experimental Biology and Medicine. Dr. Shyamal Desai and her co-investigators from the Louisiana State University School of Medicine in New Orleans, the University of Pennsylvania School of Medicine in...

2012-01-03 14:28:50

Either heart failure or diabetes alone is bad enough, but oftentimes the two conditions seem to go together. Now, researchers reporting in the January Cell Metabolism appear to have found the culprit that leads from heart failure to diabetes and perhaps a novel way to break that metabolic vicious cycle. "Our findings clarify the reasons why the incidence of heart failure is high among diabetic patients, why the prevalence of insulin resistance is increased in heart failure patients, and...

2011-12-27 08:46:14

Researchers of VIB and UGent have discovered a new approach to preventing septic shock, an often fatal extreme inflammatory reaction of the body. It is the most frequent cause of death at intensive care departments in hospitals. In sepsis, acute inflammation is attended by low blood pressure and blood clots, causing the organs to stop working. Only recently, the Brazilian football legend Socrates, died of the consequences of this condition. In a new study in the top journal Immunity, Peter...

2011-12-22 15:29:05

Sepsis, a form of systemic inflammation, is the leading cause of death in critically ill patients. Sepsis is linked with massive cell death; however, the specific mechanisms involved in the lethality of sepsis are unclear. Now, a new study published by Cell Press in the December 23rd issue of the journal Immunity finds that inhibition of a specific cell death pathway called "necroptosis" protected mice from lethal inflammation. The research may lead to new therapeutic interventions for fatal...

2011-12-14 19:28:52

The research team at Lyon has developed an animal model carrying a mutation of the DCC gene. Mice carrying the mutation develop tumors, because this gene can no longer induce the death of the cancer cells. This discovery could lead to the development of a new targeted cancer treatment that aims to reactivate the dying of cancer cells. The results of this study have been published as a Letter in the 11th December 2011 issue of the journal Nature. The team led by Patrick Mehlen, Director...

2011-12-13 22:36:37

Something rotten never smelled so sweet. This is what members of a team of scientists at Cold Spring Harbor Laboratory (CSHL) are telling one another as they discuss a new finding they did not expect to make. They have discovered that hydrogen sulfide (H2S) — the flammable, highly toxic gas that we usually associate with the smell of rotten eggs in landfills and sewers — plays an important role in the regulation of a signaling pathway implicated in biological malfunctions...

2011-12-13 07:00:00

SAN DIEGO, Dec. 13, 2011 /PRNewswire/ -- Cylene Pharmaceuticals, Inc. announced today that two of its first-in-class agents, both inhibitors of newly-validated targets, have demonstrated encouraging activity in several preclinical models of high risk leukemias, cancers for which there are limited clinical treatment options. Dr. Ross Hannan of the Peter MacCallum Cancer Centre (PMCC), Melbourne, Australia, reported how CX-5461, a targeted inhibitor of RNA Polymerase I (Pol I),...