Latest Apoptosis Stories
This approach is described in the work published today in the Journal of Clinical Investigation, which sheds light on the mechanisms that regulate squamous cell carcinoma development Skin squamous cell carcinoma (SCC) is a subtype of very aggressive skin cancers that usually develops in sunexposed body regions, but can also affect a large number of organs such as the bladder, esophagus, lungs etc. However, little is known about the biology of these cells, which consequently makes difficult...
Researchers at Georgetown Lombardi Comprehensive Cancer Center have uncovered a single molecule they say is a major determinant of resistance to anti-estrogen therapy used to treat or prevent breast cancer in high-risk women. In the July 1 issue of Cancer Research, the scientists say glucose-regulated protein 78 (GRP78), activated as breast cells undergo stress induced by the agents tamoxifen and fulvestrant, turns off apoptosis, a cell death response, and turns on autophagy. In autophagy,...
(Ivanhoe Newswire) – Researchers have discovered a single molecule that they say is a major cause of resistance to anti-estrogen therapy used to prevent or treat breast cancer in high-risk women. The researchers say glucose-regulated protein 78 (GRP78), which is triggered as breast cells become stressed from the agents tamoxifen and fulvestrant, turns off apoptosis (a cell death response) and turns on autophagy. Autophagy occurs when the cell "eats" and digests components within the cell...
Prions, the causal agents of Mad Cow and other diseases, are very unique infectious particles. They are proteins in which the complex molecular three-dimensional folding process just went astray. For reasons not yet understood, the misfolding nature of prions is associated to their ability to sequester their normal counterparts and induce them to also adopt a misfolding conformation. The ever-growing crowd of misfolded proteins form the aggregates seen in diseases such as Parkinson's and...
An unexpected discovery of how the body controls cell death has revealed a potential new therapeutic target. A research team based at Cardiff University's School of Biosciences has already revealed the mechanism by which high alcohol intake can induce pancreatitis and its progression to pancreatic cancer. Now a new study, published in Current Biology, reveals a hitherto unknown interaction between two well known molecules, which has important implications for our understanding of...
PENZBERG, Germany, June 13, 2012 /PRNewswire/ -- The co-cultivation of two different cell types is an important way to investigate cell-cell interactions and communication. Co-cultivation can be used in a wide variety of applications, including cell signalling and toxicology testing. A key goal in drug discovery is to identify how to most effectively monitor cell-cell interactions when cells show pathology. Roche Applied Science is now providing the new E-Plate Insert...
Mutated tumor suppressor gene p53 leads to better results Presence of normal p53, a tumor suppressor gene, instead of a mutated version, makes breast cancer chemotherapy with doxorubicin less effective. The preclinical study led by MD Anderson scientists was published today in the journal Cancer Cell. The research, which challenges the existing paradigm, is another step closer to personalized cancer medicine for breast cancer. "It's really important to understand the genetic defects...
ADAM28, a metalloproteinase belonging to the ADAM gene family, cleaves the von Willebrand factor (VWF) and inhibits VWF-mediated cancer cell apoptosis, thereby enhancing lung metastases, so inhibiting its expression gives a substantial reduction in lung metastases, according to a study published June 8 in the Journal of The National Cancer Institute. Several ADAMs are known to be found in tumors and are linked with both tumor growth and cancer progression in humans. While ADAM28 is...
NEW YORK, June 6, 2012 /PRNewswire/ -- Senesco Technologies, Inc. (NYSE: SNT), today announced that Leslie J. Browne, Ph.D., CEO & President, will present at RetailInvestorConferences.com. DATE: June 7, 2012 TIME: 3:00 PM EDT LINK: www.retailinvestorconferences.com > red "register / watch event now" button This will be a live, interactive online event where investors are invited to ask the company questions in real-time - both in the presentation hall as...
Scientists build a synthetic peptide that overcomes cancer cells’ survival defenses Scientists at the Dana-Farber/Children's Hospital Cancer Center have developed an anti-cancer peptide that overcomes the stubborn resistance to chemotherapy and radiation often encountered in certain blood cancers when the disease recurs following initial treatment. The strategy could pave the way for much needed new therapies to treat relapsed and refractory blood cancers, which are difficult to cure...
