Quantcast
Last updated on April 19, 2014 at 8:45 EDT

Latest Applied genetics Stories

2009-06-23 11:14:06

Pancreatic cancer is a devastating disease with poor prognosis. This warrants the development of novel therapies including gene therapy. However, clinical studies have demonstrated poor efficacy of adenoviral gene therapy because of the absence of adenoviral binding sites on pancreatic cancer cells such as the coxsackie and adenovirus receptor (CAR). Circumventing CAR-mediated entry therefore seems a promising option to improve adenoviral entry into pancreatic cancer cells and to enhance the...

2009-06-11 12:38:54

Strategy could have implications for multiple tumor typesResearchers at Nationwide Children's Hospital and Johns Hopkins University have discovered that delivering a small molecule that is highly expressed in normal tissues but lost in diseased cells can result in tumor suppression.MicroRNAs (miRNA) are a class of small RNA molecules that are highly expressed in normal tissues and are critical in gene expression and in maintaining normal cell development and cell balance. Dysfunction of...

2009-06-11 12:37:01

A new study suggests that delivering small RNAs, known as microRNAs, to cancer cells could help to stop the disease in its tracks. microRNAs control gene expression and are commonly lost in cancerous tumors. Researchers have shown that replacement of a single microRNA in mice with an extremely aggressive form of liver cancer can be enough to halt their disease, according to a report in the June 12 issue of the journal Cell, a Cell Press publication. They delivered the microRNA to the mice...

2009-06-09 14:55:23

South Korean medical scientists say a new lung cancer therapy employing a vaporized viral vector has shown early promise in a mouse model of lung cancer. The researchers at South Korea's Ministry of Education, Science and Technology said the vaporized viral vector is used to deliver a cancer-inhibiting molecule directly to lung tissue. Although gene therapy is an area of great promise, the scientists said delivery mechanisms have proven problematic for effective delivery of genetic therapy to...

2009-05-28 14:15:00

Phase 1 Data Demonstrate Safety and Evidence of Biological Activity in 9 of 12 Patients; Phase 2 Study Currently Enrolling in 17 Leading U.S. Medical Centers SAN DIEGO, May 28 /PRNewswire/ -- Celladon Corporation presented today Phase 1 data from the Calcium Up-Regulation by Percutaneous Administration of Gene Therapy in Cardiac Disease (CUPID), a First-in-Human Phase 1/2 Clinical Trial, in a scientific symposium at the 12th Annual American Society of Gene Therapy Meeting. The Phase 1...

2009-05-07 00:00:00

AMSTERDAM, May 7 /PRNewswire-FirstCall/ -- Amsterdam Molecular Therapeutics (Euronext: AMT), a leader in the field of human gene therapy, announced today the treatment of the first patient in a preregistration clinical trial with Glybera(TM). This gene therapy product targets lipoprotein lipase deficiency (LPLD), a seriously debilitating and potentially lethal disease. The randomized controlled trial has been designed to gather additional data on the effects of Glybera on lipid...

2009-05-05 13:46:40

Flemish scientists say they have developed an improved and safer technique to deliver genes into the body's cells during genetic therapy. Gene therapy is the introduction of genetic material into a patient's cells resulting in a cure or a therapeutic effect, said researchers at the Flanders Institute for Biotechnology in Belgium. The success of gene therapy ultimately depends on the gene delivery vehicles, or vectors, and most vectors have been derived from viruses that can be tailor-made to...

2009-05-04 07:14:47

Gene therapy Gene therapy is the introduction of genetic material into a patient's cells resulting in a cure or a therapeutic effect. In recent years, it has been shown that gene therapy is a promising technology to treat or even cure several fatal diseases for which there is no attractive alternative therapy. Gene therapy can be used for hereditary diseases, but also for other diseases that affect heart, brain and even for cancer. Indeed, recent results suggest that gene therapy can be...

2009-04-29 15:08:00

PRINCETON, N.J., April 29 /PRNewswire-FirstCall/ -- Orchid Cellmark Inc., (Nasdaq: ORCH), today announced that Thomas A. Bologna, President and Chief Executive Officer of Orchid Cellmark, is scheduled to present at the 2009 Bank of America Health Care Conference in New York City on Wednesday, May 13, 2008 at 4:00 p.m. EDT Mr. Bologna will provide a brief corporate overview and discuss the company's recent and ongoing progress. A link to the live webcast of Mr. Bologna's presentation will be...

3877238ff3d5c5a33d11159b22e0d313
2009-04-08 09:05:00

Scientists at the University of Michigan have developed a method of gene delivery that appears safe for regenerating tooth-supporting gum tissue"”a discovery that assuages one of the biggest safety concerns surrounding gene therapy research and tissue engineering.The figures show microcomputed tomographic images of regenerated periodontium (tooth supporting structures) following delivery of PDGF genes.Gene therapy is an accepted, viable therapeutic concept, but safety is a major hurdle,...