Latest ARNTL Stories

2014-04-16 10:13:27

All organisms, from mammals to fungi, have daily cycles controlled by a tightly regulated internal clock, called the circadian clock. The whole-body circadian clock, influenced by the exposure to light, dictates the wake-sleep cycle. At the cellular level, the clock is controlled by a complex network of genes and proteins that switch each other on and off based on cues from their environment. Most genes involved in the regulation of the circadian clock have been characterized, but Akihiro...

2013-12-20 10:34:33

Reprogramming of liver ‘clock’ may contribute to metabolic disorders A high-fat diet affects the molecular mechanism controlling the internal body clock that regulates metabolic functions in the liver, UC Irvine scientists have found. Disruption of these circadian rhythms may contribute to metabolic distress ailments, such as diabetes, obesity and high blood pressure. There’s good news, though. The researchers also discovered that returning to a balanced, low-fat diet normalized...

2013-06-19 14:29:34

Gladstone-led study sheds light on molecular basis for metabolic health and disease Inside each of us is our own internal timing device. It drives everything from sleep cycles to metabolism, but the inner-workings of this so-called "circadian clock" are complex, and the molecular processes behind it have long eluded scientists. But now, researchers at the Gladstone Institutes have discovered how one important protein falls under direct instructions from the body's circadian clock....

2013-04-10 10:55:21

Understanding how oncogenes affect the body clock may help create better cancer treatments The Myc oncogene can disrupt the 24-hour internal rhythm in cancer cells. Postdoctoral fellow Brian Altman, PhD, and graduate student Annie Hsieh, MD, both from the in the lab of Chi Van Dang, MD, PhD, director of the Abramson Cancer Center, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, present their data in the "Metabolic Pathway Regulation in...

2010-07-13 15:21:41

Disruption of two genes that control circadian rhythms can lead to diabetes, a researcher at UT Southwestern Medical Center has found in an animal study. Mice with defective copies of the genes, called CLOCK and BMAL1, develop abnormalities in pancreatic cells that eventually render the cells unable to release sufficient amounts of insulin. "These results indicate that disruption of the daily clock may contribute to diabetes by impairing the pancreas' ability to deliver insulin," said Dr....

2008-08-28 03:00:22

By Saey, Tina Hesman Work could lead to drugs for obesity, aging and jet lag Cue stomach rumbles SIRT1 sets internal clock To metabolism Timing is everything, especially when it comes to basic biological functions such as eating, sleeping and liver activity. Scientists have known for ages that metabolism is tied to the body's daily rhythms but have not known how. Now, two groups of researchers report in the July 25 Cell the discovery of a molecule that links metabolism to the...

Word of the Day
  • Exultant; jubilant; triumphant; on the high horse.
  • Tipsy; slightly intoxicated.
This word may come from the phrase 'to set cock on hoop,' or 'to drink festively.' Its origin otherwise is unclear. A theory, according to the Word Detective, is that it's a 'transliteration of the French phrase 'coq a huppe,' meaning a rooster displaying its crest ('huppe') in a pose of proud defiance.' Therefore, 'cock-a-hoop' would 'liken a drunken man to a boastful and aggressive rooster.'