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Latest Aromatase inhibitor Stories

2012-04-02 15:50:49

Scientists at Washington University School of Medicine in St. Louis are using powerful DNA sequencing technology not only to identify mutations at the root of a patient's tumor — considered key to personalizing cancer treatment — but to map the genetic evolution of disease and monitor response to treatment. "We're finding clinically relevant information in the tumor samples we're sequencing for discovery-oriented research studies," says Elaine Mardis, PhD, co-director of The...

2012-04-02 15:31:10

At the time of diagnosis, the majority of breast cancers are categorized as estrogen-receptor positive, or hormone sensitive, which means their cancerous cells may need estrogen to grow. Patients with this type of cancer often respond favorably to treatments called aromatase inhibitors, like tamoxifen, which cause cell death by preventing estrogen from reaching the cancerous cells. Over time, however, the disease often becomes resistant to estrogen deprivation from the drugs–making...

2012-01-19 13:34:16

Aromatase inhibitors (AIs) prevent the conversion of androgens to estrogens, and could play a role in the development of breast cancer. This study of 36 pre-menopausal women consisted of a cross-over intervention trial to determine if there were differences between red wine and white wine in their effects on AIs. Subjects sequentially consumed eight ounces of red wine, followed by white wine (or vice versa), each beverage for a one-month period. The investigators concluded that red wine, but...

Breast Cancer Risk Reduced With Moderate Red Wine Consumption
2012-01-09 11:22:26

Researchers from Cedars-Sinai Medical Center in Los Angeles are challenging the widely-held belief that the risk of breast cancer is increased by any type of alcohol consumption. Women who enjoy a regular glass of red wine could actually be reducing their risks according to a new medical study. Alcohol, doctors have long known, increases the body´s estrogen levels, fostering the growth of cancer cells. However, the Cedars-Sinai study found that chemicals in the skins and seeds of...

2012-01-06 12:08:42

Drinking red wine in moderation may reduce one of the risk factors for breast cancer, providing a natural weapon to combat a major cause of death among U.S. women, new research from Cedars-Sinai Medical Center shows. The study, published online in the Journal of Women's Health, challenges the widely-held belief that all types of alcohol consumption heighten the risk of developing breast cancer. Doctors long have determined that alcohol increases the body's estrogen levels, fostering the...

2011-12-16 08:51:53

(Ivanhoe Newswire) — Exemestane, a drug that is thought to prevent breast cancer, steadily lowers that levels of ℠good´ cholesterol in women taking the agent. Exemestane, an aromatase inhibitor used to treat estrogen receptor-positive breast cancer, is being tested to prevent breast cancer in women at an increased risk of developing the disease. Georgetown researchers suggest that the effect this agent has on blood lipids may prove to be significant for women at high risk...

2011-12-07 11:25:09

Knowing biology of early or late recurring tumors could help extend survival by identifying interventions to delay or prevent recurrences after tamoxifen An international research team led by Georgetown Lombardi Comprehensive Cancer Center has found biological differences in hormone-receptor positive breast cancer that are linked to the timing of recurrence despite endocrine therapy. They say their findings, presented at the 2011 CTRC-AACR San Antonio Breast Cancer Symposium, may help...

2011-12-07 10:46:49

Researchers may have discovered a series of genes that will help predict whether or not a woman with hormone receptor-positive invasive breast cancer will experience early, late or no recurrence of her disease. Minetta C. Liu, M.D., associate professor of medicine and oncology and director of translational breast cancer research at Georgetown Lombardi Comprehensive Cancer Center, presented the findings at the 2011 CTRC-AACR San Antonio Breast Cancer Symposium, held Dec. 6-10, 2011....

2011-11-14 11:36:38

Clinical benefit from use of a novel histone deacetylase inhibitor drug may be determined by examining blood cells days after a patient receives treatment. The drug, entinostat, is the first histone deacetylase inhibitor successfully tested in a randomized, placebo-controlled study in metastatic breast cancer – and is the first to show that clinical outcome can be predicted shortly after administration. The findings, reported at the AACR-NCI-EORTC International Conference: Molecular...

2011-11-11 18:22:35

Researchers exploring why some women who take a common breast cancer drug develop serious joint pain have eliminated two possible causes: inflammatory arthritis and autoimmune disease. Because of these findings, researchers say women should be encouraged to continue taking the medication to gain its full benefit. The study is published online Nov. 11 in the journal Breast Cancer Research and Treatment. Preliminary findings were presented in 2010 at the 74th Annual Scientific Meeting of the...


Word of the Day
tessitura
  • The prevailing range of a vocal or instrumental part, within which most of the tones lie.
This word is Italian in origin and comes from the Latin 'textura,' web, structure.