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2014-07-10 10:24:42

Penn State The drug letrozole results in higher birth rates in women with polycystic ovary syndrome (PCOS) than the current preferred infertility treatment drug, according to a nationwide study led by Penn State College of Medicine researchers. PCOS affects 5 to 10 percent of reproductive-age women and is the most common cause of female infertility. Women affected have excessive levels of the hormone androgen, have infrequent periods, develop small cysts on the ovaries and have trouble...

2014-03-26 16:11:46

A breast cancer therapy that blocks estrogen synthesis to activate cancer-killing genes sometimes loses its effectiveness because the cancer takes over epigenetic mechanisms, including permanent DNA modifications in the patient's tumor, once again allowing tumor growth, according to an international team headed by the University of Pittsburgh Cancer Institute (UPCI). The finding warrants research into adding drugs that could prevent the cancer from hijacking patients' repressive gene...

2014-03-24 08:28:34

SAN DIEGO, March 24, 2014 /PRNewswire/ -- Seragon Pharmaceuticals Inc., a clinical-stage biotechnology company focused on the development of drugs for hormone-driven cancers, today announced the appointment of N. Anthony Coles (Tony), M.D. to the company's Board of Directors. Dr. Coles brings nearly 30 years of experience in the healthcare, biotechnology and pharmaceutical industries. Most recently, Dr. Coles served as President, Chief Executive Officer and Chairman of the Board of...

2014-03-20 23:22:02

Entinostat is being investigated in patients with advanced hormone receptor-positive breast cancer by the ECOG-ACRIN Cancer Research Group in its latest trial, E2112. Philadelphia, PA, and Waltham, MA (PRWEB) March 20, 2014 The ECOG-ACRIN Cancer Research Group (ECOG-ACRIN) and Syndax Pharmaceuticals, Inc., announced today that patient recruitment has begun for E2112, a randomized phase III clinical trial of Syndax’s entinostat in treatment of patients with advanced breast cancer. The...

2014-01-17 23:03:42

Certain medications can reduce a woman's risk for developing breast cancer. Women at high risk for breast cancer should talk with their doctors about this strategy. Boston, MA (PRWEB) January 17, 2014 Many new and potent medicines to prevent breast cancer have become available in the past 20 years. Surprisingly, many women—even those at high risk for the disease—are not taking advantage of these medicines, according to an article in the January 2014 issue of the Harvard...

2013-12-13 09:37:18

A Phase I trial of endoxifen, an active metabolite of the cancer drug tamoxifen, indicates that the experimental drug is safe, with early evidence for anti-tumor activity, a Mayo Clinic study has found. The findings indicate that Z-endoxifen, co-developed by Mayo Clinic Cancer Center and the National Cancer Institute (NCI), may provide a new and better treatment for some women with estrogen positive breast cancer and, in particular, for those women who do not respond to tamoxifen and...

Reducing Risk Of Breast Cancer With Promising New Drug Treatment
2013-12-12 10:25:15

Rebekah Eliason for redOrbit.com – Your Universe Online There is good news for postmenopausal women who are at high risk for developing breast cancer. According to a new study, taking the drug anastrozole for five years reduced the likelihood of developing the disease by 53 percent when compared with women who took a placebo. Approximately 80 percent of women in the United States who are diagnosed with breast cancer have tumors that contain high levels of hormone receptors. These...

Breast Cancer Risk From High Cholesterol
2013-11-30 04:57:15

Rebekah Eliason for redOrbit.com - Your Universe Online Researchers have discovered a byproduct of cholesterol that functions similarly to the hormone estrogen and stimulates the growth and spread of common forms of breast cancer cells. Encouragingly, researchers also found that certain anti-cholesterol drugs, like statins, seem to reduce the harmful effects of the estrogen-like molecule. The researchers caution, however, that the study's findings are still early in their development....

New Driver Of Breast Cancer Discovered
2013-11-07 12:35:45

UT Southwestern Medical Center A team of researchers at UT Southwestern has found that as cholesterol is metabolized, a potent stimulant of breast cancer is created – one that fuels estrogen-receptor positive breast cancers, and that may also defeat a common treatment strategy for those cancers. The multidisciplinary team discovered that a cholesterol metabolite called 27-hydroxycholesterol, or 27HC, promotes tumor growth in estrogen-receptor positive breast cancers, which are the...

2013-11-04 16:36:10

Gene sequencing reveals mutations in estrogen receptor Researchers at the University of Michigan Comprehensive Cancer Center have identified a type of mutation that develops after breast cancer patients take anti-estrogen therapies. The mutations explain one reason why patients often become resistant to this therapy. The study appears online in Nature Genetics. The discovery stems from a program at the U-M Comprehensive Cancer Center called Mi-ONCOSEQ in which patients with advanced...


Word of the Day
abrosia
  • Wasting away as a result of abstinence from food.
The word 'abrosia' comes from a Greek roots meaning 'not' and 'eating'.