Latest Arp2/3 complex Stories
University of Oregon biochemists have determined how tiny synthetic molecules disrupt an important actin-related molecular machine in cells in one study and, in a second one, the crystal structure of that machine when bound to a natural inhibitor.
Cells on the move reach forward with lamellipodia and filopodia, cytoplasmic sheets and rods supported by branched networks or tight bundles of actin filaments.
Most cells rely on structural tethers to position chromosomes in preparation for cell division.
Revealing another part of the story of muscle development, Johns Hopkins researchers have shown how the cytoskeleton from one muscle cell builds finger-like projections that invade into another muscle cellâ€™s territory, eventually forcing the cells to combine.
In this study, Shuichi Takeda at Nagoya University and colleagues present the X-ray crystal structures of the actin capping protein (CP) complexed with its inhibitors, V-1 and CARMIL, and demonstrate that the two regulators modulate the filament capping activity in very different manners.
The APC protein serves as the colon's guardian, keeping tumors at bay.
University of Oregon-made technique is putting new light on machinery driving intracellular transport.
Notch signaling helps determine the fate of a number of different cell types in a variety of organisms, including humans.
- To play, gamble.
- To impose upon; delude; trick; humbug; also, to joke; chaff.
- A deceitful game or trick; trickery; humbug; nonsense.