Quantcast

Latest Arp2/3 complex Stories

2013-07-29 16:33:05

Crystal structure of a key initiation protein while bound is captured in one of two newly reported studies University of Oregon biochemists have determined how tiny synthetic molecules disrupt an important actin-related molecular machine in cells in one study and, in a second one, the crystal structure of that machine when bound to a natural inhibitor. The accomplishments -- done in the name of fundamental understanding, or basic science -- provide new windows on the complexities of...

2012-04-09 09:35:14

Cells on the move reach forward with lamellipodia and filopodia, cytoplasmic sheets and rods supported by branched networks or tight bundles of actin filaments. Cells without functional lamellipodia are still highly motile but lose their ability to stay on track, report researchers at the Stowers Institute for Medical Research in the April 9, 2012, online issue of the Journal of Cell Biology. Their study provides new insight into cell motility, a complex and integrated process, which, when...

2011-08-29 12:07:09

Most cells rely on structural tethers to position chromosomes in preparation for cell division. Not so oocytes. Instead, a powerful intracellular stream pushes chromosomes far-off the center in preparation for the highly asymmetric cell division that completes oocyte maturation upon fertilization of the egg, report researchers at the Stowers Institute for Medical Research. Their findings illustrate how oocytes repurposed a dynamic cellular mechanism capable of generating considerable...

2011-06-06 12:58:43

Revealing another part of the story of muscle development, Johns Hopkins researchers have shown how the cytoskeleton from one muscle cell builds finger-like projections that invade into another muscle cell's territory, eventually forcing the cells to combine. Such muscle cell fusion, the researchers say, is not only important for understanding normal muscle growth, but also muscle regeneration after injury or disease. The work, they believe, could further development of therapies for muscular...

2010-07-07 12:42:14

In this study, Shuichi Takeda at Nagoya University and colleagues present the X-ray crystal structures of the actin capping protein (CP) complexed with its inhibitors, V-1 and CARMIL, and demonstrate that the two regulators modulate the filament capping activity in very different manners. These findings will be published next week in the online, open access journal PLoS Biology. Dynamic rearrangement of actin cytoskeleton structure is fundamental to many cellular processes, such as neuronal...

2010-06-22 01:59:57

The APC protein serves as the colon's guardian, keeping tumors at bay. Now researchers reveal a new function for the protein: helping to renovate the cytoskeleton by triggering actin assembly. The result suggests a second way that mutations in APC could lead to cancer. The study appears online on June 21 in the Journal of Cell Biology (www.jcb.org). A faulty APC gene occurs in more than 80% of colon cancers and is one of the early "gateway" mutations leading to abnormal growth. Researchers...

2009-12-17 16:57:01

University of Oregon-made technique is putting new light on machinery driving intracellular transport Using new technology developed in his University of Oregon lab, chemist Andrew H. Marcus and his doctoral student Eric N. Senning have captured what they describe as well-orchestrated, actin-driven, mitochondrial movement within a single cell. That movement -- documented in a paper appearing online the week of Dec. 14-18 ahead of regular publication in the Proceedings of the National Academy...

2009-06-22 09:54:37

"“ Notch signaling helps determine the fate of a number of different cell types in a variety of organisms, including humans. In an article that appears in the current issue of Nature Cell Biology, researchers at Baylor College of Medicine report that a new finding about the Notch signaling pathway in sensory organ precursor cells in the fruit fly could explain the mystery behind an immunological disorder called Wiskott-Aldrich syndrome."This finding provides a model for how Wiskott...


Word of the Day
endocarp
  • The hard inner (usually woody) layer of the pericarp of some fruits (as peaches or plums or cherries or olives) that contains the seed.
This word comes from the Greek 'endon,' in, within, plus the Greek 'kardia,' heart.
Related