Latest Array comparative genomic hybridization Stories

2009-06-03 13:29:00

ALISO VIEJO, Calif., June 3 /PRNewswire/ -- Ambry Genetics is pleased to announce the launch of whole-genome Chromosomal Microarray Analysis (CMA), offering the Ambry CMA: 105K Oligo Array, which is designed to identify chromosomal abnormalities associated with over 270 genetic disorders. In a partnership with Baylor College of Medicine, Ambry is now able to provide one of the most comprehensive, clinically-validated genetic tests available using array comparative genomic hybridization....

2009-05-05 10:48:00

ALISO VIEJO, Calif., May 5 /PRNewswire/ -- Ambry Genetics Corp. announces the implementation of Comparative Genomic Hybridization (CGH) using oligonucleotide arrays through a partnership with Baylor College of Medicine. Large chromosomal abnormalities that are associated with over 270 genetic syndromes can be easily identified via analysis of each 105K whole genome and mitochondrial array. The partnership with Baylor College of Medicine equips Ambry with an extensive library as a reference,...

2009-01-27 07:07:52

A fertility clinic in Nottingham, England has announced the world's first pregnancy using a new technique that screens eggs for abnormalities that cause in vitro fertilization (IVF) to fail. Researchers from the CARE Fertility clinic have found a way of extracting a "spare" set of chromosomes inside the egg and rapidly analyzing them"”a technique that could have the potential to significantly improve couples' chances of having successful treatment. The study suggests chromosomal...

2008-10-11 03:00:07

By Muradyan, Artur Boldt, Vivien; Steininger, Anne; Stabentheiner, Stephanie; Tebel, Katrin; Kreutzberger, Jurgen; Muller, Ines; Madle, Hannelore; Popper, Helmut H; Ullmann, Reinhard The accumulation of chromosomal aberrations is a characteristic feature of tumor development. However, an understanding of tumorigenesis that assumes that changes in DNA copy number always cause equivalent changes in the corresponding RNA and protein levels is an oversimplification and completely ignores the...

2008-10-07 09:00:56

Researchers from France investigating DNA copy number changes associated with genetic disorders have reported the development and validation of a Roche NimbleGen CGH multiplex, microarray-based research method for detecting genomic deletions and duplications at high-resolution. The findings, published in the August 5 issue of the journal Human Mutation (1), identified highly precise, exon-level variants in DNA samples from affected individuals and carriers of a range of human diseases...

2008-07-30 09:00:23

Chromosomal rearrangements leading to genomic disorders are often mediated by low-copy repeat regions of the genome (e.g. segmental duplications). Roche NimbleGen CGH arrays offer expanded probe coverage in these regions. Using this technique, the authors of a recently published paper(1) identified a recurrent reciprocal genomic rearrangement of chromosomal region 17q12 in fetal samples with congenital anomalies that is also associated with pediatric renal disease and epilepsy. The results...

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