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Latest Arrestin Stories

2014-06-23 13:34:53

Duke University Medical Center A team of scientists from Duke Medicine, the University of Michigan and Stanford University has determined the underlying architecture of a cellular signaling complex involved in the body's response to stimuli such as light and pain. This complex, consisting of a human cell surface receptor and its regulatory protein, reveals a two-step mechanism that has been hypothesized previously but not directly documented. The findings, reported on June 22, 2014,...

2013-04-22 22:29:32

A three-dimensional image of one of the proteins that serves as an on-off switch as it binds to receptors on the surface of a cell suggests there may be a sort of main power switch that could be tripped. These surface receptors are responsible for helping cells discern light, set the heart racing, or detect pain. The finding, published online April 21, 2013, in the journal Nature by a research collaboration involving this year's Nobel laureates in chemistry, could help in the development...

2013-03-22 09:39:00

A team including scientists from The Scripps Research Institute (TSRI), the University of North Carolina at Chapel Hill and the Chinese Academy of Sciences has determined and analyzed the high-resolution atomic structures of two kinds of human serotonin receptor. The new findings help explain why some drugs that interact with these receptors have had unexpectedly complex and sometimes harmful effects. "Understanding the structure-function of these receptors allows us to discover new...

2012-12-03 20:47:58

Scientists from VIB and KU Leuven have discovered a new target molecule for the development of a treatment against Alzheimer's disease. There is currently no cure for this disease. Many candidate drugs fail because they also target proteins essential to life. This discovery from Leuven could form a target for a treatment against Alzheimer's disease with fewer side effects and that suppresses the very first symptoms of the disease. This research will be published in the leading journal Nature...

2012-02-09 15:02:46

UC Riverside scientists identify a protein that plays a crucial role in learning and memory Biomedical scientists at the University of California, Riverside have identified a new link between a protein called beta-arrestin and short-term memory that could open new doors for the therapeutic treatment of neurological disorders, particularly Alzheimer's disease. Beta-arrestin is expressed in various cells of the body, including cells of the hippocampus, the region of the brain that is...

2010-11-16 19:35:44

A Nova Southeastern University researcher has announced a breakthrough discovery to block a protein that can contribute to heart failure A Nova Southeastern University (NSU) researcher has announced a breakthrough discovery to block a protein that can contribute to heart failure. His discovery will appear in an upcoming issue of the prestigious medical journal, the Journal of the American College of Cardiology. Anastasios Lymperopoulos, Ph.D., an NSU College of Pharmacy assistant professor of...

2010-05-10 07:21:45

Researchers in the Department of Biochemistry and Molecular Biology at Thomas Jefferson University have found that the level of a single protein in the tiny roundworm C. elegans determines how long it lives. Worms born without this protein, called arrestin, lived about one-third longer than normal, while worms that had triple the amount of arrestin lived one-third less. The research also showed that arrestin interacts with several other proteins within cells to regulate longevity. The human...

2009-10-08 09:35:27

The natural cycle of building bone to maintain skeletal strength and then breaking it down for the body's calcium needs is delicately balanced, but diseases like osteoporosis break down too much bone without adequate bone replacement, leading to bone fractures. The results from a new study at Duke suggest a targeted approach by which drugs may be able to fight osteoporosis and other degenerative bone diseases. Diane Gesty-Palmer, M.D., a Duke Assistant Professor of Endocrinology and...

2009-04-08 08:34:13

Niacin is known to help lower levels of "bad" cholesterol and raise levels of "good" cholesterol, and it gets the job down at a significantly lower cost than other cholesterol lowering medications on the market today. Unfortunately, the drug, also known as nicotinic acid, is rarely used anymore due to a troublesome side effect. Specifically, it can cause unwanted flushing of the skin that leads to a burning sensation and itching. Researchers from Duke University Medical Center are working on...


Word of the Day
callithump
  • A somewhat riotous parade, accompanied with the blowing of tin horns, and other discordant noises; also, a burlesque serenade; a charivari.
'Callithump' is a back-formation of 'callithumpian,' a 'fanciful formation' according to the Oxford English Dictionary. However, the English Dialect Dictionary, says 'Gallithumpians' is a Dorset and Devon word from the 1790s that refers to 'a society of radical social reformers' or 'noisy disturbers of elections and meetings.'
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