Latest Arthur G. James Stories

-Triple-negative breast cancer is an aggressive form of breast cancer that has few treatment options; -This large-scale study shows that abnormal levels of small molecules called microRNA can be used to classify this malignancy into four subtypes; -The findings could lead to new ways to identify the best therapy for individual patients and to more effective therapies in the future. A new, large-scale study of triple-negative breast cancer shows that small molecules called microRNA can be...

-People who develop chronic lymphocytic leukemia (CLL) are typically age 65 and older, but participants in CLL clinical trials are usually several years younger; -The age of CLL patients is not usually considered when determining treatment; -This study suggests that older and younger CLL patients require different therapy. Doctors should use different therapies when treating older and younger patients with chronic lymphocytic leukemia, according to a new study led by researchers at the...

-People newly diagnosed with chronic leukemia must often wait to learn if they have a faster- or slower-progressing form of the disease. -This study identified a molecular marker that quickly helps to distinguish which form a patients has. -The findings could enable patients with aggressive disease to start treatment sooner. Researchers have identified a prognostic marker in the most common form of chronic leukemia that can help to distinguish which patients should start treatment...

Researchers have identified a molecule that helps control the severity of graft-versus-host disease, a life-threatening complication for many leukemia patients who receive a bone-marrow transplant. The study, led by researchers with the Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James), used an animal model and tissues from human patients to show that high levels, or over-expression, of a...

The many short pieces of mobile DNA that exist in the genome can contribute to significant biological differences between lineages of mice, according to a new study led by researchers at the Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James). The movable pieces of DNA are called transposons or "jumping genes" because they can move from one chromosomal location to another. Unlike viruses, they are...

A new study shows that it is possible to selectively target and block a particular microRNA that is important in liver cancer. The finding might offer a new therapy for this malignancy, which kills an estimated 549,000 people worldwide annually.   The animal study, by researchers at The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) and at Mayo Clinic, focused on microRNA-221 (miR-221), a...

The study shows how normal cells in tumors can enhance the growth of the tumor’s cancer cells after losing an important tumor suppressor gene called Pten.   The findings suggest a new strategy for treating breast cancer by interrupting signals between normal cells and cancer cells in tumors.    A new study published in the journal Nature Cell Biology has discovered how normal cells in tumors can fuel tumor growth.   Led by researchers at the Ohio State University Comprehensive...

A new study has identified a gene mutation that researchers estimate dates back to 11,600 B.C., making it the second oldest human disease mutation yet discovered.   Researchers with the Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute led the study and estimate that the mutation arose in the Middle East some 13,600 years ago. Only a mutation seen in cystic fibrosis that arose between 11,000 and 52,000 years ago...

Older people with acute myeloid leukemia and normal looking chromosomes in their cancer cells have a higher risk of recurrence if they have mutations in a gene called ASXL1, according to a new study by researchers at the Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James). The study is the first to investigate the influence of these gene mutations on prognosis in patients with cytogenetically...

Men are three times more likely than women to develop a common form of skin cancer but medical science doesn’t know why. A new study may provide part of the answer.   Researchers at The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) have found that male mice had lower levels of an important skin antioxidant than female mice and higher levels of certain cancer-linked inflammatory cells.  ...