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Last updated on April 17, 2014 at 21:23 EDT

Latest Ashutosh Chilkoti Stories

2011-01-25 15:31:48

Duke University bioengineers have developed a new method for rapidly producing an almost unlimited variety of man-made DNA sequences. These novel sequences of recombinant DNA are used to produce repetitive proteins to create new types of drugs and bioengineered tissues. Current methods for producing these DNA sequences are slow or not robust, the researchers said, which has hindered the development of these increasingly important new classes of protein-based polymers. Researchers have already...

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2009-11-01 14:52:39

Going smaller could bring better results, especially when it comes to cancer-fighting drugs. Duke University bioengineers have developed a simple and inexpensive method for loading cancer drug payloads into nano-scale delivery vehicles and demonstrated in animal models that this new nanoformulation can eliminate tumors after a single treatment. After delivering the drug to the tumor, the delivery vehicle breaks down into harmless byproducts, markedly decreasing the toxicity for the...

2009-08-20 12:45:52

U.S. bioengineers say a new method they created for attaching a large protective polymer molecule to a protein appears to significantly improve protein drugs. The Duke University researchers say they've used an animal model to demonstrate the new protein-polymer combinations, known as conjugates, remained in circulation significantly longer than an unprotected protein. The scientists say their accomplishment represents a new strategy to improve the efficacy of protein drugs. Unmodified...

2009-08-19 16:02:07

A new method for attaching a large protective polymer molecule to a protein appears to improve protein drugs significantly.Bioengineers at Duke University developed the new approach and demonstrated in an animal model that the newly created protein-polymer combinations, known as conjugates, remained in circulation significantly longer than an unprotected protein.The scientists say they are encouraged that their findings represent a new strategy to improve the efficacy of protein...

2005-10-13 04:51:25

DURHAM, N.C. -- Duke engineers have added a new construction tool to their bio-nanofabrication toolbox. Using an enzyme called TdTase, engineers can vertically extend short DNA chains attached to nanometer-sized gold plates. This advance adds new capability to the field of bio-nanomanufacturing. "The process works like stacking Legos to make a tower and is an important step toward creating functional nanostructures out of biological materials," said Ashutosh Chilkoti, associate professor of...