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Latest Atrophy Stories

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2010-03-22 08:47:58

A new study in the Journal of Cell Biology (JCB) identifies a cytokine signaling pathway that induces the breakdown of disused skeletal muscle. Blocking this pathway could prevent immobilized patients from losing their muscle tissue. The article appears in the March 22 issue of the JCB. Skeletal muscle wastes away when its activity is reduced by, for example, a spinal cord injury. Although the mechanism by which muscle fibers break down is understood fairly well, how the process is triggered...

2010-03-02 07:30:00

OSAKA, Japan, ATLANTA and ANN ARBOR, Mich., March 2 /PRNewswire/ -- Shionogi & Co., Ltd. and QuatRx Pharmaceuticals Company, a privately-held pharmaceutical company, today announced that they have entered into a worldwide license agreement to develop and market ospemifene, a selective estrogen receptor modulator ("SERM"). Under the terms of this agreement, Shionogi will have worldwide marketing rights to ospemifene. QuatRx will receive an up-front payment of $25 million and is eligible...

2010-03-01 07:48:29

Reversing a protein deficiency through gene therapy can correct motor function, restore nerve signals and improve survival in mice that serve as a model for the lethal childhood disorder spinal muscular atrophy, new research shows. This muscle-wasting disease results when a child's motor neurons "“ nerve cells that send signals from the spinal cord to muscles "“ produce insufficient amounts of what is called survival motor neuron protein, or SMN. This reduced protein in motor...

2010-01-04 15:22:50

New research in the FASEB Journal shows free radicals damage mitochondria in our muscle cells, resulting in age-related muscle loss If you're an aging baby boomer hoping for a buffer physique, there's hope. A team of American scientists from Texas and Michigan have made a significant discovery about the cause of age-related muscle atrophy that could lead to new drugs to halt this natural process. This research, available online the FASEB Journal (http://www.fasebj.org), shows that free...

2009-12-10 14:00:53

Findings could lead to novel therapeutic intervention strategies for neuromuscular disorders; data published in latest issue of Science  miRagen Therapeutics, Inc., a biopharmaceutical company focused on improving patients' lives by developing innovative microRNA-based therapeutics for cardiovascular and muscle disease, today announced the publication of data demonstrating that microRNA-206 (miR-206) plays a crucial role in the progression of amyotrophic lateral sclerosis (ALS or Lou...

2009-12-01 14:29:14

In order to maintain muscle strength with age, cells must rid themselves of the garbage that accumulates in them over time, just as it does in any household, according to a new study in the December issue of Cell Metabolism, a Cell Press journal. In the case of cells, that waste material includes spent organelles, toxic clumps of proteins, and pathogens. The researchers made their discovery by studying mice that were deficient for a gene required for the tightly controlled process of...

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2009-10-01 06:14:41

A study led by researchers at the University of California, Berkeley, has identified critical biochemical pathways linked to the aging of human muscle. By manipulating these pathways, the researchers were able to turn back the clock on old human muscle, restoring its ability to repair and rebuild itself. The findings were reported in the Sept. 30 issue of the journal EMBO Molecular Medicine, a peer-reviewed, scientific publication of the European Molecular Biology Organization. "Our study...

2009-08-28 11:25:00

LIBERTYVILLE, Ill., Aug. 28 /PRNewswire-USNewswire/ -- Families of Spinal Muscular Atrophy (Libertyville, IL) announced today that the Office of Orphan Products Development of the Food and Drug Administration (FDA) has granted Orphan Drug Designation to Quinazoline495 for the treatment of Spinal Muscular Atrophy. This is the first time a new therapy specifically designed for Spinal Muscular Atrophy has ever reached the important stage of being awarded orphan drug status by the FDA....

2009-07-29 07:00:00

ANN ARBOR, Mich., July 29 /PRNewswire/ -- QuatRx Pharmaceuticals Company, a privately-held biopharmaceutical company, today announced positive top-line efficacy results from the first of two patient cohorts in its second pivotal Phase 3 trial of the investigational compound, Ophena(TM) (ospemifene tablets), for the treatment of postmenopausal vulvovaginal atrophy (VVA). The Company has also successfully completed two long term safety extension studies from its first pivotal Phase 3...

2009-06-12 07:33:17

New research shows that muscle atrophy is a much more ordered and deliberate process than previously thought. During atrophy, which can occur when the body is weak from a disease such as cancer or AIDS, the body cannibalizes itself and breaks down muscle proteins to liberate amino acids. According to a new study, scientists have learned that a specific enzyme selectively degrades the thick filaments in the muscle but leaves the thin filaments alone. This allows muscles to remain muscles and...


Word of the Day
sough
  • A murmuring sound; a rushing or whistling sound, like that of the wind; a deep sigh.
  • A gentle breeze; a waft; a breath.
  • Any rumor that engages general attention.
  • A cant or whining mode of speaking, especially in preaching or praying; the chant or recitative characteristic of the old Presbyterians in Scotland.
  • To make a rushing, whistling, or sighing sound; emit a hollow murmur; murmur or sigh like the wind.
  • To breathe in or as in sleep.
  • To utter in a whining or monotonous tone.
According to the OED, from the 16th century, this word is 'almost exclusively Scots and northern dialect until adopted in general literary use in the 19th.'
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