Latest Attenuated vaccine Stories

Georgia Institute of Technology Research News Measles vaccine given with painless and easy-to-administer microneedle patches can immunize against measles at least as well as vaccine given with conventional hypodermic needles, according to research done by the Georgia Institute of Technology and the Centers for Disease Control and Prevention (CDC). In the study, the researchers developed a technique to dry and stabilize the measles vaccine – which depends on a live attenuated virus –...

Rapid mutation has long been considered a key to viral adaptation to environmental change. But in the case of the coronavirus responsible for deadly severe acute respiratory syndrome (SARS), collaborating researchers at the University of North Carolina and Vanderbilt University have found that accelerating the rate of mutations cripples the virus's ability to cause disease in animals. In addition, they say this finding may allow scientists to explore a new option for creating safer live...

Connie K. Ho for redOrbit.com – Your Universe Online Researchers from Arizona State University (ASU) recently revealed novel technology that could help protect against a number of pathogens at lower costs and with improved methods. A re-engineered bacterium that can quicken the delivery of the DNA vaccines to host cells, the new platform was found to provide complete protection against influenza in mice. The team of investigators believes that the new technique could be manufactured...

BEIJING, Sept. 18, 2012 /PRNewswire/ -- Sinovac Biotech Ltd. (Nasdaq: SVA), a leading China-based vaccine manufacturer, announced today that it has received GMP certification from the China State Food and Drug Administration (SFDA) for the Company's dedicated mumps vaccine production plant at its Sinovac Dalian facility. The SFDA issued a public announcement on September 12, 2012, stating that the Good Manufacturing Practices (GMP) certification was issued to Sinovac with the...

Research from the University of Melbourne has shown that two different vaccine viruses- used simultaneously to control the same condition in chickens- have combined to produce new infectious viruses, prompting early response from Australia's veterinary medicines regulator. The vaccines were used to control infectious laryngotracheitis (ILT), an acute respiratory disease occurring in chickens worldwide. ILT can have up to 20% mortality rate in some flocks and has a significant economic and...

Brett Smith for redOrbit.com - Your Universe Online Australian scientists looking to vaccinate chicken populations against a respiratory disease may have accidentally unleashed a disease far more deadly than the one they hoped to prevent. According to a report published this week in Science, the genomes from two different strains of the herpesvirus infectious laryngotracheitis (ILT) virus that were used in vaccines have recombined to produce more virulent ILT viruses near Sydney and...

Salmonella Typhi (S. Typhi) is the causative agent of typhoid fever, a serious health threat resulting in some 22 million new cases yearly and approximately 217,000 fatalities.  A number of novel vaccine candidates using live attenuated strains of Salmonella are being developed, but care must be taken to ensure the bacteria are not excreted into the environment following vaccination. Karen Brenneman and her colleagues at Arizona State University’s Biodesign Institute have been examining...

Infectious diseases—both old and new—continue to exact a devastating toll, causing some 13 million fatalities per year around the world. Vaccines remain the best line of defense against deadly pathogens and now Kathryn Sykes and Stephen Johnston, researchers at Arizona State University’s Biodesign Institute, along with co-author Michael McGuire from the University of Texas Southwestern Medical Center are using clever functional screening methods to attempt to speed new vaccines into...

Declaring the eradication of polio will be far more difficult than it was for smallpox, according to a review published in the Journal of General Virology. Further research into the complex virus - host interactions and how the vaccine is used in the final stages of the eradication program is crucial to its success. Poliomyelitis, also known as infantile paralysis, was one of the most feared diseases of the 1950s. By the mid 1970s, thanks to vaccination, the viral disease had been...

(Ivanhoe Newswire) -- A new class of therapeutics, known as recombinant attenuated Salmonella vaccines (RASV), may fight against fatal diseases such as hepatitis B, tuberculosis, cholera, typhoid fever, AIDS and pneumonia, according to a new study.Researchers from Arizona State University have developed a way to make these vaccines safer and more effective. They demonstrated that a modified strain of Salmonella showed a five-fold reduction in virulence in mice, while preserving strong...