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Latest Aurora A kinase Stories

2012-08-21 10:31:50

The Nek9 protein is required for chromosomes to separate into two identical groups. Nek9 exerts its action between two molecules of interest for the pharmaceutical industry as anti-tumoral agents, and for which inhibitors are already in advanced stages of clinical trials. Nek9 could be added to the list of candidates. A study by the Institute for Research in Biomedicine (IRB Barcelona) and the Center for Genomic Regulation (acronym in Catalan CRG) highlights the protein Nek9 as a...

2011-12-10 01:29:11

Suppressing a newly identified and characterized protein involved in regulating cell division could be a novel strategy to fight certain cancers because it stops the malignant cells from dividing and causes them to die quickly, according to a study by researchers with UCLA's Jonsson Comprehensive Cancer Center. During the five-year study, designed to seek new targets for anti-cancer therapies, researchers discovered that depleting the protein, called STARD9, also helped the commonly used...

2011-06-30 17:58:14

New information from fission yeast provides clues for research on cancer treatments When a cell divides, the genetic information in the chromosomes must be passed on error-free to the daughter cells. Researchers at the Friedrich Miescher Laboratory in Tbingen are studying this process using fission yeast as a model organism. In cooperation with researchers at the University of Tbingen, they succeeded in attributing additional tasks to the Aurora enzymes, which were already recognized as...

2011-06-13 15:44:08

The Aurora A kinase may contribute to polycystic kidney disease (PKD) by inactivating a key calcium channel in kidney cells, according to a study in the June 13 issue of The Journal of Cell Biology (www.jcb.org). Aurora A is an oncogene best known as a regulator of mitotic progression. But the kinase has important functions during interphase as well, when it can promote cilia disassembly and can be activated by elevated calcium levels. Because both calcium signaling and cilia are defective in...

2010-10-11 13:15:42

Phase II trial A drug being developed as a treatment for ovarian cancer has shown single agent activity with durable disease control in some patients in a Phase-II clinical trial, an international research group has reported. Dr Ursula Matulonis from Dana-Farber Cancer Institute in the USA reported the results of the single-agent trial of the drug, called MLN8237, in a poster at the 35th Congress of the European Society for Medical Oncology (ESMO). MLN8237 selectively inhibits an enzyme known...

2010-07-20 09:59:00

WASHINGTON, July 20 /PRNewswire-USNewswire/ -- A major discovery, led by researchers from The George Washington University Medical Center, promises to revolutionize the way scientists think about key aspects of cellular lifecycle and offers a new avenue for cancer researchers to explore in their quest to one day slow down the progression of cancer. The discovery, reported in the article "Arpc 1b, a centrosomal protein, is both an activator and substrate of Aurora A," furthers the science...


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