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Latest Autophagy Stories

2014-06-29 12:21:03

WASHINGTON, June 29, 2014 /PRNewswire-USNewswire/ -- In work supported by The ALS Association, researchers have shown that increasing the clearance of misfolded protein from neurons improves their survival. The study was published today in the journal Nature Chemical Biology. http://photos.prnewswire.com/prnvar/20131211/MM32178LOGO ALS (amyotrophic lateral sclerosis), also known as Lou Gehrig's disease, is a progressive neurodegenerative disease that affects motor neurons (nerve...

2014-04-09 16:31:50

Researchers headed by Antonio Zorzano at IRB demonstrate that the DOR protein promotes muscle mass loss in mice. The scientists hypothesize that the design of an inhibitor against DOR would serve to prevent and tackle muscle wasting in patients suffering from sarcopenia and cachexia. The pathological atrophy of skeletal muscle is a serious biomedical problem for which no effective treatment is currently available. Those most affected populations are the elderly diagnosed with sarcopenia...

2014-04-07 15:48:32

A University of Colorado Cancer Center study recently published in the journal Cell Reports and presented today at the American Association for Cancer Research (AACR) Annual Conference 2014 shows that the cellular process of autophagy in which cells "eat" parts of themselves in times of stress may allow cancer cells to recover and divide rather than die when faced with chemotherapies. Autophagy, from the Greek "to eat oneself," is a process of cellular recycling in which cell organelles...

2014-04-01 14:28:49

Experts analyze baker's yeast to discover potential for combating neurological conditions like Parkinson's and even cancer A humble ingredient of bread – baker's yeast – has provided scientists with remarkable new insights into understanding basic processes likely involved in diseases such as Parkinson's and cancer. In a new study published today (Monday March 31) in the prestigious journal PNAS (Proceedings of the National Academy of Science), the team from Germany, Leicester, and...

2014-03-29 23:01:54

A new study finds that a drug that kills bladder cancer cells with light works even better when another compound is added. Raleigh, NC (PRWEB) March 29, 2014 The Chinese developers of a light-based treatment for bladder cancer say the treatment can be improved with the addition of a second drug. Click here to read the findings, which have just been posted on the Cancer Monthly website. Doctors in the Department of Urology at Fudan University in Shanghai have concluded that the...

2014-02-07 13:01:17

Researchers from North Carolina State University have found a link between a mutation in a gene called RAB 24 and an inherited neurodegenerative disease in Old English sheepdogs and Gordon setters. The findings may help further understanding of neurodegenerative diseases and identify new treatments for both canine and human sufferers. Hereditary ataxias are an important group of inherited neurodegenerative diseases in people. This group of diseases is the third most common...

2014-02-04 11:07:09

Opening up a can of worms is a good way to start hunting for new drugs, recommend researchers from Children's Hospital of Pittsburgh of UPMC and the University of Pittsburgh School of Medicine. In a study published today in the Public Library of Science One, they used a primitive worm model to show that a drug typically used to treat agitation in schizophrenia and dementia has potential as a treatment for α-1 antitrypsin (AT) deficiency, an inherited disease that causes severe liver...

2014-01-13 10:39:26

When a tumor is treated with an anti-cancer drug, some cells die and, unfortunately, some cells tend to live. A University of Colorado Cancer Center study published in the journal Nature Cell Biology details a possible difference between the susceptible and resistant cells: the rate at which cells are able to cleanse themselves via the process known as autophagy. “In these studies, say we treat cells with the IC-50 of a drug – at that dose, 50 percent of cells should live and 50...

2013-12-30 16:02:49

TAU researchers find inhibition of a basic cellular process may contribute to the mysterious disease Surprisingly little is known about schizophrenia. It was only recognized as a medical condition in the past few decades, and its exact causes remain unclear. Since there is no objective test for schizophrenia, its diagnosis is based on an assortment of reported symptoms. The standard treatment, antipsychotic medication, works less than half the time and becomes increasingly ineffective over...

2013-12-06 11:27:42

What makes yellow fever vaccine especially effective One of the most effective vaccines in history has been the yellow fever vaccine, which was developed in the 1930s and has been administered to more than 500 million people. Scientists at Emory Vaccine Center studying immune responses to the yellow fever vaccine have identified a gene whose activation in key immune cells is a sign of a robust response. The gene, called GCN2, encodes a protein involved in sensing amino acid starvation...


Word of the Day
callithump
  • A somewhat riotous parade, accompanied with the blowing of tin horns, and other discordant noises; also, a burlesque serenade; a charivari.
'Callithump' is a back-formation of 'callithumpian,' a 'fanciful formation' according to the Oxford English Dictionary. However, the English Dialect Dictionary, says 'Gallithumpians' is a Dorset and Devon word from the 1790s that refers to 'a society of radical social reformers' or 'noisy disturbers of elections and meetings.'
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