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Latest Autophagy Stories

2012-07-04 04:20:03

Singapore, July 4, 2012 - (ACN Newswire) - A*STAR scientists from the Institute of Molecular and Cell Biology (IMCB) and the Singapore Bioimaging Consortium (SBIC) have discovered a new signalling pathway that controls both obesity and atherosclerosis. The team demonstrated, for the first time, that mice deficient in the Wip1 gene were resistant to weight gain and atherosclerosis via regulation of the Ataxia telangiectasia mutated gene (ATM) and its downstream signalling molecule mTor. These...

2012-07-02 21:42:17

Researchers at Georgetown Lombardi Comprehensive Cancer Center have uncovered a single molecule they say is a major determinant of resistance to anti-estrogen therapy used to treat or prevent breast cancer in high-risk women. In the July 1 issue of Cancer Research, the scientists say glucose-regulated protein 78 (GRP78), activated as breast cells undergo stress induced by the agents tamoxifen and fulvestrant, turns off apoptosis, a cell death response, and turns on autophagy. In autophagy,...

2012-07-02 06:07:17

(Ivanhoe Newswire) — Researchers have discovered a single molecule that they say is a major cause of resistance to anti-estrogen therapy used to prevent or treat breast cancer in high-risk women. The researchers say glucose-regulated protein 78 (GRP78), which is triggered as breast cells become stressed from the agents tamoxifen and fulvestrant, turns off apoptosis (a cell death response) and turns on autophagy. Autophagy occurs when the cell "eats" and digests components within the...

2012-06-18 11:59:39

A multi-institutional research study has uncovered a new mechanism that may lead to unique treatments for lung cancer, one of the leading causes of death worldwide. The study recently published in the journal Genes & Development was a collaboration between Sanford-Burnham Medical Research Institute, Virginia Commonwealth University (VCU) Massey Cancer Center and the VCU Institute of Molecular Medicine, the University of California, San Diego, the University of Minnesota and St. Jude...

2012-06-15 12:00:47

Preclinical study links aging and cancer, with lethal host metabolism in the tumor microenvironment It has long been known that cancer is a disease of aging, but a molecular link between the two has remained elusive. Now, researchers at the Kimmel Cancer Center at Jefferson (KCC) have shown that senescence (aging cells which lose their ability to divide) and autophagy (self-eating or self-cannibalism) in the surrounding normal cells of a tumor are essentially two sides of the same coin,...

2012-05-08 11:32:55

Potent new drug kills tumor cells in mice by clogging up their recycling system All cells have the ability to recycle unwanted or damaged proteins and reuse the building blocks as food. But cancer cells have ramped up the system, called autophagy, and rely on it to escape damage in the face of chemotherapy and other treatments. Now, researchers at the Perelman School of Medicine; the Abramson Cancer Center; and the School of Arts and Sciences, at the University of Pennsylvania, have...

2012-04-25 21:23:00

DNA from the heart's own cells plays a role in heart failure by mistakenly activating the body's immune system, according to a study by British and Japanese researchers DNA from the heart's own cells plays a role in heart failure by mistakenly activating the body's immune system, according to a study by British and Japanese researchers, co-funded by the British Heart Foundation (BHF). Scientists from King's College London and Osaka University Medical School in Japan showed that during...

2012-04-23 12:47:00

Pathogen interferes with important survival process in cells whose job is to fight infection Scientists have found why a certain type of bacteria, harmless in healthy people, is so deadly to patients with cystic fibrosis. The bacterium, Burkholderia cenocepacia, causes a severe and persistent lung infection in patients with CF and is resistant to nearly all known antibiotics. Cystic fibrosis is a chronic disorder characterized by a buildup of mucus in the lungs and other parts of the...

2012-03-22 09:09:15

A new finding in basic science should trigger a "change in thinking" about how cancer drugs might be developed and tested for maximum effectiveness, says Louis M. Weiner, M.D., director of the Georgetown Lombardi Comprehensive Cancer Center, in a "Clinical Implications of Basic Research" article titled Tumor-Cell Death, Autophagy, and Immunity published in the March 22 issue of the New England Journal of Medicine (NEJM). An internationally known expert in immunotherapy research, Weiner was...

2012-02-21 06:05:55

(Ivanhoe Newswire) — Blocking autophagy — the process of "self-eating" within cells — is turning out to be a viable way to enhance the effectiveness of a wide variety of cancer treatments. Autophagy increases in cancer cells. Normally, it serves as a survival pathway, allowing a cell to recycle damaged proteins when it's under stress and reuse the damaged parts to fuel further growth. It is believed, that cancer cells might be addicted to autophagy, since this innate...


Word of the Day
omadhaun
  • A fool; a simpleton: a term of abuse common in Ireland and to a less extent in the Gaelic-speaking parts of Scotland.
This word is partly Irish in origin.