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Latest Autophagy Stories

2011-05-16 18:15:14

Whitehead Institute researchers have found that depriving human melanoma cells of the essential amino acid leucine can be lethal to the cells, suggesting a possible strategy for therapeutic intervention. The researchers observed the effect in melanoma cells with a mutation in the RAS/MEK signaling pathway"”the most common mutation found in the deadliest form of skin cancer. Leucine is one of nine essential amino acids humans must ingest, as we are unable to synthesize them. These nine,...

2011-04-11 09:13:00

SAN DIEGO, April 11, 2011 /PRNewswire/ -- Polaris Group (Polaris) announced today that data from preclinical studies of ADI-PEG 20, the Company's pegylated arginine deiminase therapeutic, is synergistic with hydroxychloroquine (ChQ) in a human pancreatic cancer cell line and with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in human melanoma cell lines. Both ChQ and TRAIL are known inhibitors of autophagy. These results support the commencement of Phase 1/2 clinical...

2011-03-16 18:30:21

Cells, which employ a process called autophagy to clean up and reuse protein debris leftover from biological processes, were the original recyclers. A team of scientists from Paul Greengard's Rockefeller University laboratory have linked a molecule that stimulates autophagy with the reduction of one of Alzheimer's disease's major hallmarks, amyloid peptide. Their finding suggests a mechanism that could be used to eliminate built-up proteins in diseases such as Alzheimer's, Down syndrome,...

2011-03-15 20:39:13

Promising strategy moves quickly to human trials Dana-Farber Cancer Institute scientists report they have shrunk or slowed the growth of notoriously resistant pancreatic tumors in mice, using a drug routinely prescribed for malaria and rheumatoid arthritis. The pre-clinical results, which will appear in the April issue of the journal Genes & Development and is currently published on its web site, have already prompted the opening of a small clinical trial in patients with advanced...

2011-03-08 15:30:00

Research by the University of Liverpool has found that systemic inflammation caused by sepsis can be suppressed by a protein which occurs naturally in a type of roundworm. Sepsis is a serious inflammatory condition, caused by the body over-reacting to infection. The body becomes overwhelmed by bacteria, setting off a series of reactions that lead to inflammation and clotting.  It affects around 20 million people worldwide each year, and accounts for a large proportion of intensive care...

2011-02-25 19:32:21

Discovery of killer cells has potential for targeted cancer therapies Scientists at Trinity College Dublin have made an important discovery concerning how fledgling cancer cells self-destruct, which has the potential of impacting on future cancer therapies. The Trinity research group, led by Smurfit Professor of Medical Genetics, Professor Seamus Martin and funded by Science Foundation Ireland, has just published their findings in the internationally renowned journal, Molecular Cell....

2010-09-20 22:18:48

A protein linked to Parkinson's disease may cause neurodegeneration by inhibiting autophagy"”the process in which cells digest some of their contents"”according to a study in the September 20 issue of the Journal of Cell Biology (www.jcb.org). Autophagy serves to clear a variety of toxic waste from cells, including misfolded proteins and defective mitochondria. These two types of cellular trash accumulate in neurons from Parkinson's patients, suggesting that autophagy could be...

2010-09-07 13:04:58

Like some people, cells eat when they are under pressure"”but they consume parts of themselves. A multi-function protein helps control this form of cannibalism, according to a study in the September 6 issue of the Journal of Cell Biology (www.jcb.org). Cells often respond to hunger or stress by digesting some of their contents. The process, known as autophagy, helps free nutrients and clean up cytoplasmic trash such as worn-out organelles and misshapen proteins. A team led by...

2010-06-24 04:12:21

A team of researchers, led by Carlos L³pez-Otín, at Universidad de Oviedo, Spain, has identified in mice an essential role for the cellular process known as autophagy in inner ear development and balance sensing. The team hopes that these data will provide new understanding of human balance disorders, which are of increasing relevance as the elderly population expands, and possibly new therapeutic approaches. Autophagy is an evolutionarily conserved process by which...

2010-06-03 17:20:13

The liver scarring of ÃŽ±1-antitrypsin (AT) deficiency, the most common genetic cause for which children undergo liver transplantation, might be reversed or prevented with a medication that has long been used to treat seizures, according to findings from Children's Hospital of Pittsburgh of UPMC and the University of Pittsburgh School of Medicine that will published in Science and are available online today through the Science Express website. Because the anti-seizure drug...


Word of the Day
tesla
  • The unit of magnetic flux density in the International System of Units, equal to the magnitude of the magnetic field vector necessary to produce a force of one newton on a charge of one coulomb moving perpendicular to the direction of the magnetic field vector with a velocity of one meter per second. It is equivalent to one weber per square meter.
This word is named for Nikola Tesla, the inventor, engineer, and futurist.