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Latest Autosomal dominant polycystic kidney Stories

2014-06-11 08:30:16

-Special Protocol Assessment for trial design and planned analysis agreed upon by the U.S. Food & Drug Administration PRINCETON, N.J., June 11, 2014 /PRNewswire/ -- Otsuka Pharmaceutical Development & Commercialization, Inc., announced today that patient enrollment has begun for a new Phase 3b study of tolvaptan for adult patients with autosomal dominant polycystic kidney disease (ADPKD), the most common, life-threatening, inherited genetic kidney disorder.(1) The company reached an...

2013-10-03 15:59:37

A new study published today in British Journal of Pharmacology has identified that a component of grapefruit and other citrus fruits, naringenin, successfully blocks the formation of kidney cysts. Known as polycystic kidney disease, this is an inherited disorder which leads to the loss of kidney function, high blood pressure and the need for dialysis. Few treatment options are currently available. The team of scientists from Royal Holloway University, St George's, University of London...

2013-09-06 12:26:52

Study uses induced pluripotent stem cells to identify kidney disease defect New research has uncovered a process that is defective in patients with autosomal dominant polycystic kidney disease, a common cause of kidney failure. The findings, which appear in an upcoming issue of the Journal of the American Society of Nephrology (JASN), point to a new potential strategy for preventing and treating the disease. Polycystic kidney disease (PKD), the fourth leading cause of kidney failure...

2013-07-18 11:17:26

Findings point to new diagnostic category Researchers at Columbia University Medical Center (CUMC) and collaborators have identified a genetic mutation that causes congenital malformations of the kidney and urinary tract, a common form of birth defect and the most common cause of kidney failure in children. It is the first time that a specific genetic mutation has been linked to a non-syndromic form of urinary tract malformation. The findings were published in the July 17 online issue of...

2012-11-05 15:03:03

A drug therapy shows promise for treating an inherited form of kidney disease called autosomal dominant polycystic kidney disease (ADPKD), Mayo Clinic researchers say. The medication, tolvaptan, slowed the pace of kidney cyst growth over the three years of the study. The phase three clinical trial results were being presented today at the American Society of Nephrology annual meeting and published online in the New England Journal of Medicine. The multicenter study found tolvaptan...

2011-12-06 23:17:59

Research presented at ASCB annual meeting After a four-week course of the vasodilator hormone relaxin, kidney function and blood flow immediately improved in lab rats genetically altered to model polycystic kidney disease (PKD), a life-threatening genetic disorder, according to research presented on Dec. 6 at the American Society for Cell Biology Annual Meeting in Denver. In addition to widening the blood vessels, relaxin lowered the collagen scores of the PKD rats, indicating that the...

2011-10-25 09:46:04

Genetic testing could identify children at risk The most common kidney disease passed down through families, autosomal dominant polycystic kidney disease (ADPKD) affects one in 400 to 1,000 individuals and is characterized by cysts on the kidneys. The condition slowly gets worse and leads to kidney failure. Most ADPKD cases arise in adults, but some patients show severe symptoms of the disease in early childhood. New research indicates that these severely affected patients carry, in...


Word of the Day
endocarp
  • The hard inner (usually woody) layer of the pericarp of some fruits (as peaches or plums or cherries or olives) that contains the seed.
This word comes from the Greek 'endon,' in, within, plus the Greek 'kardia,' heart.
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