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Latest Azacitidine Stories

2012-01-23 10:47:41

UT MD Anderson researchers expose molecular connection between inflammation, methylation Chronic inflammation combines with DNA methylation, a process that shuts down cancer-fighting genes, to promote development of colorectal cancer, scientists at The University of Texas MD Anderson Cancer Center report today in the advance online publication of the journal Nature Medicine. The team's connection of these two separate influences eventually may lead to better combination therapies for...

2011-11-10 15:26:29

COMBINATION 'EPIGENETIC' THERAPY MAY RESTORE ANTI-CANCER GENE ACTIVITY IN LATE-STAGE LUNG CANCER PATIENTS Small clinical trial shows promising positive effects A new type of therapy aimed at reversing the gene-silencing that promotes cancer-cell growth has shown promising results in a small clinical trial conducted by researchers at the Johns Hopkins Kimmel Cancer Center.  Forty-five late-stage lung cancer patients who received a two-drug combination designed to restore anti-cancer...

2010-12-11 00:30:30

Combination given to AML, MDS patients who have second disease and no options A two-drug combination is safe and active in newly diagnosed acute myeloid leukemia and myelodysplastic syndrome patients who are usually excluded from clinical trials because they have other illnesses or poor performance status - a measure of disease progression - researchers reported this week at the 52nd American Society of Hematology Annual Meeting. "Our findings suggest current eligibility standards that...

2010-12-06 03:25:00

PALO ALTO, Calif., Dec. 6, 2010 /PRNewswire/ -- Telik, Inc. (Nasdaq: TELK) today announced positive results from a Phase 2 multicenter trial of oral ezatiostat hydrochloride (TELINTRA, TLK199) in patients with an International Prognostic System Score (IPSS) of low to intermediate-1 risk myelodysplastic syndrome (MDS). The presentation entitled Phase 2 Randomized Multicenter Study of Extended Dosing Schedules of Oral Ezatiostat HCl (Telintra), a Glutathione Analog,...

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2010-05-09 13:13:12

Chemical changes in the genetic material, known as epigenetic modifications, regulate the activity of many genes. Thus, attachment of methyl groups to DNA often inactivates important cellular growth brakes. Therefore, this process called methylation is believed to be a major cause of uncontrolled division of cancer cells. Specific enzymes, the DNA methyltransferases, are responsible for methylation. Unlike changes in the blueprint of the genetic material, epigenetic mutations are reversible...

2010-04-26 07:00:00

WALTHAM, Mass., April 26 /PRNewswire/ -- Decision Resources, one of the world's leading research and advisory firms for pharmaceutical and healthcare issues, finds that Celgene's Vidaza (azacitidine) (seven-day dosing) will retain Decision Resources' proprietary clinical gold standard status through 2013 for the treatment of high-risk myelodysplastic syndromes. While some emerging drugs in development hold promise, none offer significant survival advantages over Vidaza. A modified dosing...

2009-05-05 07:00:00

The Need for More-Efficacious Treatments Creates Significant Opportunity for Drug Developers in this Niche Market, According to a New Report from Decision Resources WALTHAM, Mass., May 5 /PRNewswire/ -- Decision Resources, one of the world's leading research and advisory firms for pharmaceutical and healthcare issues finds that, through 2012, growth in the myelodysplastic syndromes drug market will be driven principally by the launch in Europe of Celgene's Vidaza and Revlimid. Launch of...

2009-02-18 07:30:00

VIDAZA Restores Gene Function to Double Survival and Increase Transfusion Independence CROSSWICKS, N.J., Feb. 18 /PRNewswire/ -- The Myelodysplastic Syndromes (MDS) Foundation says data published in the peer reviewed medical journal The Lancet Oncology confirms VIDAZA extends survival for patients with higher-risk MDS. Myelodysplastic syndromes are a group of blood-related malignancies that are difficult to treat and in higher-risk patients have a median survival rate of less than one year....


Word of the Day
omadhaun
  • A fool; a simpleton: a term of abuse common in Ireland and to a less extent in the Gaelic-speaking parts of Scotland.
This word is partly Irish in origin.