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Scientists with Berkeley Lab and Einstein College of Medicine Extend Conventional Click Chemistry to Living Cells Biomolecular imaging can reveal a great deal of information about the inner workings of cells and one of the most attractive targets for imaging are glycans "“ sugars that are ubiquitous to living organisms and abundant on cell surfaces. Imaging a glycan requires that it be tagged or labeled. One of the best techniques for doing this is a technique called click chemistry....
For the first time, the widely used molecular synthesis technique known as click chemistry has been safely applied to a living organism. Researchers with Lawrence Berkeley National Laboratory (Berkeley Lab) and the University of California (UC) Berkeley have crafted a unique copper-free version of click chemistry to create biomolecular probes for in vivo studies of live mice. Conventional click chemistry reactions require a copper catalyst that is toxic to cells and organisms. "We developed a...
- Like a worm in form or movement; vermiform; tortuous or sinuous; also, writhing or wriggling.
- Like the track or trace of a worm; appearing as if worm-eaten; vermiculate.
- Marked with fine, close-set, wavy or tortuous lines of color; vermiculated.
- A form of rusticated masonry which is so wrought as to appear thickly indented with worm-tracks.