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Latest Aziz Sancar Stories

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2011-07-26 09:57:15

Researchers who have been working for nearly a decade to piece together the process by which an enzyme repairs sun-damaged DNA have finally witnessed the entire process in full detail in the laboratory. What they saw contradicts fundamental notions of how key biological molecules break up during the repair of sunburn "“ and that knowledge could someday lead to drugs or even lotions that could heal sunburn in humans. In the Proceedings of the National Academy of Sciences (PNAS), the Ohio...

2010-12-29 13:54:04

In a new paper published this week in the Proceedings of the National Academy of Sciences, Aziz Sancar, MD, PhD, the Sarah Graham Kenan Professor of Biochemistry and Biophysics in the UNC School of Medicine, and his colleagues have taken an important step in understanding the underlying molecular signals that influence a broad array of biological processes ranging from the sleep-wake cycle to cancer growth and development. Scientists who work in this field, known as chronobiology, have...

2009-02-05 23:01:30

Disrupting the body's time-keeping system, the circadian clock, may help slow cancer growth, U.S. researchers say. In a mouse model used to investigate cancer, genetically altering one of four essential clock genes suppressed cancer growth -- perhaps due to intracellular signals that make cancer cells more likely to commit cell suicide -- a process known as apoptosis. Adjusting the clock in this way could certainly be a new target for cancer treatment, senior study author Dr. Aziz Sancar of...

2009-02-03 15:07:27

Researchers at the University of North Carolina at Chapel Hill have shown that disruption of the circadian clock "“ the internal time-keeping mechanism that keeps the body running on a 24-hour cycle "“ can slow the progression of cancer.The study disputes some of the most recent research in the field indicating that alteration of this daily cycle predisposes humans and mice to cancer. The UNC researchers found that genetically altering one of four essential "clock" genes actually...

2009-01-13 13:05:13

For years, research has hinted that the time of day that cancer patients receive chemotherapy can impact their chances of survival. But the lack of a clear scientific explanation for this finding has kept clinicians from considering timing as a factor in treatment. Now, a new study from the University of North Carolina at Chapel Hill has suggested that treatment is most effective at certain times of day because that is when a particular enzyme system "“ one that can reverse the actions...


Word of the Day
sough
  • A murmuring sound; a rushing or whistling sound, like that of the wind; a deep sigh.
  • A gentle breeze; a waft; a breath.
  • Any rumor that engages general attention.
  • A cant or whining mode of speaking, especially in preaching or praying; the chant or recitative characteristic of the old Presbyterians in Scotland.
  • To make a rushing, whistling, or sighing sound; emit a hollow murmur; murmur or sigh like the wind.
  • To breathe in or as in sleep.
  • To utter in a whining or monotonous tone.
According to the OED, from the 16th century, this word is 'almost exclusively Scots and northern dialect until adopted in general literary use in the 19th.'
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