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Latest B cell Stories

2012-03-05 23:14:39

The generation of new memories in the human immune system doesn't come at the cost of old ones, according to a study published on March 5th in the Journal of Experimental Medicine (www.jem.org). Memory "killer" T cells are specialized cells that develop in response to specific infections and launch an accelerated attack if the specific pathogen returns. Experiments in mice have suggested that the development of new memory T cells causes the activation and subsequent demise of old...

2012-03-02 01:32:18

A new study turns the well established theory that antibodies are required for antiviral immunity upside down and reveals that an unexpected partnership between the specific and non-specific divisions of the immune system is critical for fighting some types of viral infections. The research, published online on March 1st in the journal Immunity by Cell Press, may lead to a new understanding of the best way to help protect those exposed to potentially lethal viruses, such as the rabies virus....

2012-02-14 11:25:52

At the most basic level, the immune system must distinguish self from non-self, that is, it must discriminate between the molecular signatures of invading pathogens (non-self antigens) and cellular constituents that usually pose no risk to health (self-antigens). The system is far from foolproof. Cancer cells can undergo unchecked proliferation, producing self-antigens that are tolerated by the immune system, rather than being targeted for destruction. At the opposite extreme, a range of...

2012-01-06 10:09:31

In a major shake-up of scientists' understanding of what determines the fate of cells, researchers at the Walter and Eliza Hall Institute have shown that cells have some control over their own destiny. The researchers, from the institute's Immunology division, drew their conclusion after studying B cells, immune system cells that can make antibodies. B cells can have multiple fates. Some of the more common fates are to die, divide, become an antibody-secreting cell or change what...

2011-12-23 08:29:17

Vaccines with broader reach might be made by stimulating specialized immune cells to recognize foreign cell membrane proteins that are shared across bacterial species, say researchers from Children's Hospital of Pittsburgh of UPMC and the University of Pittsburgh School of Medicine in a report published online today in Immunity. The approach could be particularly beneficial in preventing infection by multi-drug resistant organisms. The genetic heritage of organisms such as oysters, frogs...

2011-12-15 17:19:14

Steve Reiner, MD, professor of Medicine, and Burton Barnett, a doctoral student in the Reiner lab at the Perelman School of Medicine at the University of Pennsylvania, have shown how immune cells, called B lymphocytes, are able to produce daughter cells that are not equal, a finding that might explain how lifelong antibodies are made after vaccination. How do immune cells make daughter cells that are different form one another, rather than splitting into identical daughter cells? The...

2011-12-14 19:12:39

'Human immune system' mouse model closely mimics a person's specific response and resolution of a tick-borne infection known as relapsing fever Imitating human diseases using an animal model is a difficult task, but Thomas Jefferson University researchers have managed to come very close. Reporting in the Proceedings of the National Academy of Sciences, a team of Jefferson immunologists found that a specialized "human immune system" mouse model closely mimics a person's specific response...

2011-12-13 12:17:46

Researchers at the University of Toronto have found an explanation for how the intestinal tract influences a key component of the immune system to prevent infection, offering a potential clue to the cause of autoimmune disorders like rheumatoid arthritis and multiple sclerosis. "The findings shed light on the complex balance between beneficial and harmful bacteria in the gut," said Prof. Jennifer Gommerman, an Associate Professor in the Department of Immunology at U of T, whose findings...

2011-12-12 21:51:48

Research describes advantages of new vaccine adjuvant New research from the laboratory of Dr. Elizabeth Leadbetter at the Trudeau Institute may lead to a whole new class of vaccines. Dr. Leadbetter's lab has discovered new properties of a potential vaccine adjuvant that suggest it could be useful for enhancing protection against a number of different infections. This new data will be published in the January 2012 issue of the journal Nature Immunology (Vol. 13, pp. 44-50). The paper, "iNKT...

2011-10-20 22:49:19

Researchers at Boston University have made discoveries that provide the foundation towards novel approaches to control insects that transmit deadly diseases such as dengue fever and malaria through their study of the Wolbachia bacteria. Their findings have been published in the current issue of Science Express, an online publication of selected papers in advance of the print edition of Science, the main journal of the American Association for the Advancement of Science (AAAS). "Wolbachia...


Word of the Day
endocarp
  • The hard inner (usually woody) layer of the pericarp of some fruits (as peaches or plums or cherries or olives) that contains the seed.
This word comes from the Greek 'endon,' in, within, plus the Greek 'kardia,' heart.
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