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Latest B cell Stories

2011-02-22 21:15:00

Our immune systems contain three fundamentally different types of cell:  B-cells, T-cells and the mysteriously named Natural Killer cells (NK cells), which are known to be involved in killing tumor cells and other infected cells.  Experiments to investigate the function of NK cells have proven difficult to interpret because the interactions between the various components of the immune system make it almost impossible to isolate effects of individual cell types.  This has...

2011-02-18 17:14:37

First report of a recombinant human biotherapeutic active against leukemic stem cells Scientists at the Children's Center for Cancer and Blood Diseases and The Saban Research Institute of Children's Hospital Los Angeles today announced a breakthrough discovery in understanding how the body fights leukemia. They have identified a protein called CD19-ligand (CD19-L) located on the surface of certain white blood cells that facilitates the recognition and destruction of leukemia cells by the...

2011-02-02 20:37:34

Biologists have discovered that primitive, predatory lampreys have structures within their gills that play the same role as the thymus, the organ where immune cells called T cells develop in mammals, birds and fish. The finding suggests that in vertebrate evolution, having two separate organs for immune cell development -- the bone marrow for B cells and the thymus for T cells -- may have preceded the appearance of the particular features that mark those cells, such as antibodies and T cell...

2011-01-22 00:00:40

Immunologist Thomas L. Rothstein, MD, PhD, and his colleagues from The Feinstein Institute for Medical Research have staked their reputations on finding these so-called "B1 cells" that make "natural" protective antibodies and come online before the adaptive immune system is mature enough to start working. And that is precisely what they have done. Manhasset, NY (Vocus/PRWEB) January 21, 2011 It has long been thought that the human body contains innate immune defense B cells that are present...

2011-01-06 15:09:00

THOUSAND OAKS, Calif. and MONROVIA, Calif., Jan. 6, 2011 /PRNewswire/ -- Amgen (Nasdaq: AMGN) and Xencor, Inc. announced today that they will collaborate to develop XmAb(®)5871, an Fc- engineered monoclonal antibody dually targeting CD19 and CD32b. XmAb5871 is currently in late-stage preclinical development for the treatment of autoimmune diseases. Under the terms of the agreement, Amgen has the option to an exclusive worldwide license following the completion of a...

2010-12-31 12:20:16

(Ivanhoe Newswire) "“ A new study provides insight into the underlying pathology associated with the autoimmune disease, systemic lupus erythematosus (SLE). The research shows an unexpected role for a key type of immune cell could provide a potential new therapeutic strategy for SLE and, possibly, other autoimmune diseases. SLE is a chronic systemic disease that can affect many regions of the body and, as a result, presents with diverse clinical symptoms. As is characteristic of other...

2010-11-30 15:32:32

The findings challenge long-held dogma in field of immunology A team of scientists from The Scripps Research Institute have uncovered a previously unknown regulatory mechanism in the body's response to eliminate pathogens, such as bacteria and viruses. The findings challenge a long-held dogma in the field of immunology and have potential implications for far-ranging topics from how vaccines should be administered to the origin of autoimmunity. The results of the study, led by Scripps Research...

2010-10-08 02:19:58

A discovery by Walter and Eliza Hall Institute researchers in Melbourne, Australia, reported in today's edition of Science, is set to rewrite a long-held belief about how the body's immune system establishes its memory. The findings of Dr Ingela Vikstrom and Associate Professor David Tarlinton, from the institute's Immunology division, centre on immune cells called B cells that produce the antibodies which fight infection. "B cells and antibody production are the key to the success of all...

2010-10-06 17:35:14

In order to track down pathogens and render them harmless, the immune system must be able to recognize myriad different foreign substances and react to them. Scientists at the Max Planck Institute of Immunobiology and the Centre for Biological Signalling Studies BIOSS at the University of Freiburg have discovered how the immune system's B-cells can be activated by numerous substances from our environment. The receptor molecules on the surface of the B-cells are only activated when the...

2010-10-05 15:09:33

New method will simplify study and treatment of diseases Therapeutic antibodies can be an efficient alternative when common drugs do not work anymore. However, antibodies obtained from blood of animals such as mice could not be used: The human immune system recognizes them as foreign and rejects them. In an international cooperation, scientists from the Helmholtz Centre for Infection Research (HZI) in Braunschweig, Germany have now succeeded in developing a promising approach to solve this...


Word of the Day
omadhaun
  • A fool; a simpleton: a term of abuse common in Ireland and to a less extent in the Gaelic-speaking parts of Scotland.
This word is partly Irish in origin.