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Latest Bacillus Calmette-Guérin Stories

2011-09-05 11:16:45

A potential vaccine against tuberculosis has been found to completely eliminate tuberculosis bacteria from infected tissues in some mice. The vaccine was created with a strain of bacteria that, due to the absence of a few genes, are unable to avoid its host's first-line immune response. Once this first-line defense has been activated, it triggers the more specific immune response that can protect against future infections. The research, by scientists at the Howard Hughes Medical Institute,...

2011-06-27 14:15:49

Generic drug reproduces mechanism that reversed diabetes in mice, Phase II trial now underway Promising results of the Phase I clinical trial of the generic drug BCG (bacillus Calmette-Guerin) to treat advanced type I diabetes were announced today at the American Diabetes Association scientific sessions in San Diego. A research team led by Denise Faustman, MD, PhD, director of the Massachusetts General Hospital (MGH) Immunobiology Laboratory is presenting two abstracts (No. 2240-PO and No....

2011-05-24 23:00:09

Clinical trials for a new bladder cancer therapy show promising interim results. Lead researcher Alvaro Morales says that the breakthrough using the drug Urocidin follows thirty years of his research in this important area. "I am optimistic about the results of the trial," says Dr. Morales, professor emeritus in the Department of Urology at Queen's University and director of the Queen's University Centre for Applied Urological Research. "Positive results in the next phase of trials will move...

2011-05-17 15:05:00

CHADDS FORD, Pa. and BELLEVILLE, Ontario, May 17, 2011 /PRNewswire/ -- Endo Pharmaceuticals and Bioniche Life Sciences today presented Phase III trial results for the intravesical formulation of Mycobacterial cell wall-DNA complex (MCC), known as Urocidin(TM), during a podium presentation at the 2011 American Urological Association annual meeting in Washington, D.C. The preliminary results from the interim analysis of this prospective trial indicate that Urocidin(TM) may provide an...

2011-05-11 19:14:07

McGill research team found 2 distinct disease-causing mutations and saved a baby girl About two years ago, Dr. Philippe Gros, a McGill University professor in the Department of Biochemistry and a Principal Investigator in thd McGill Life Sciences Complex, described a mouse mutant that was immunodeficient and hypersensitive to the Bacille Calmette-Gu©rin (BCG) vaccine and to tuberculosis (TB). In this model, Gros's team had found that the immunodeficiency was caused by a mutation in a...

2011-03-22 23:28:05

In this week's PLoS Medicine, and to coincide with World TB Day, Madhukar Pai from McGill University in Montreal, Canada and colleagues introduce the BCG World Atlas, an open access, user friendly website for TB clinicians to discern global BCG vaccination policies and practices and improve the care of their patients. The Bacille Calmette-Gu©rin (BCG) vaccine continues to be controversial, with known variations in BCG substrains and vaccine efficacy. Vaccine policies and practices vary...

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2011-03-21 07:25:00

Scientists have discovered a protein secreted by tuberculosis (TB) bacteria that could be a promising new vaccine candidate, they report in the March 18 issue of Proceedings of the National Academy of Sciences. The protein could also be used to improve diagnosis of TB. TB is caused by the bacterium Mycobacterium tuberculosis (MTB), which infects the lungs and spreads through the air as a result of coughing. There are 9 million new cases of TB each year, killing 4,700 people a day worldwide....

2011-02-18 16:05:50

Nele Festjens and Nico Callewaert of VIB and Ghent University have improved the efficacy of the vaccine for tuberculosis. The new vaccine affords - as already proven in mice - better protection against the disease. The development of a new tuberculosis vaccine is a priority in the fight against the disease which claims the lives of 1.7 million people each year. The current vaccine provides only partial protection. Nico Callewaert: "Our vaccine is more effective because it is more quickly...

2011-02-17 17:00:00

CHADDS FORD, Pa. and BELLEVILLE, Ontario, Feb. 17, 2011 /PRNewswire/ -- Endo Pharmaceuticals (Nasdaq: ENDP) and Bioniche Life Sciences Inc. (TSX and ASX: BNC) today announced plans for peer-reviewed presentation of interim efficacy and safety results from the first Phase III trial of the intravesical formulation of Mycobacterial cell wall-DNA complex (MCC), known as Urocidin(TM) or EN3348. The results to be presented have been generated from an ongoing Phase III registration trial with...

2011-02-15 08:29:00

THE HAGUE, The Netherlands, February 15, 2011 /PRNewswire/ -- - The Ministry of Health, Welfare and Sport (Ministerie van Volkgezondheid, Welzijn en Sport) has Announced That it Commences With the Sale of the Production Activities of the 'Nederlands Vaccin Instituut' (NVI). The Sales Process Starts on February 15, 2011. In January 2010 the Minister of Health, Welfare and Sport informed the House of Representatives that the NVI was going to change course. NVI's public tasks,...


Latest Bacillus Calmette-Guérin Reference Libraries

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2011-04-18 22:11:24

Mycobacterium bovis is a slow-growing, aerobic bacterium and the causative agent of tuberculosis in cattle. Similar to M. tuberculosis, M. bovis can jump the species barrier and cause tuberculosis in humans. It is estimated that M. bovis was responsible for more losses among farm animals than all other diseases combined in the first half of the 20th century. Infection happens after bacterium is ingested. It is generally transmitted to humans via infected milk. Actual human infections are...

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Word of the Day
negawatt
  • A unit of saved energy.
Coined by Amory Lovins, chairman of the Rocky Mountain Institute as a contraction of negative watt on the model of similar compounds like megawatt.