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Latest Base pair Stories

2013-04-18 23:32:55

A research team from NPL and the University of Edinburgh have invented a new way to zip and unzip DNA strands using electrochemistry. The DNA double helix has been one of the most recognizable structures in science ever since it was first described by Watson and Crick almost 60 years ago (paper published in Nature in 25 April 1953). The binding and unbinding mechanism of DNA strands is vital to natural biological processes and to the polymerase chain reactions used in biotechnology to copy...

2012-03-19 05:12:26

Berkeley Lab scientists and their colleagues have discovered an unsuspected way that protons can move among molecules -- revealing new opportunities for research in biology, environmental science, and green chemistry When a proton — the bare nucleus of a hydrogen atom — transfers from one molecule to another, or moves within a molecule, the result is a hydrogen bond, in which the proton and another atom like nitrogen or oxygen share electrons. Conventional wisdom has it that...

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2011-01-28 09:45:07

DNA, that marvelous, twisty molecule of life, has an alter ego, research at the University of Michigan and the University of California, Irvine reveals. On rare occasions, its building blocks "rock and roll," deforming the familiar double helix into a different shape. "We show that the simple DNA double helix exists in an alternative form"”for one percent of the time"”and that this alternative form is functional," said Hashim M. Al-Hashimi, who is the Robert L. Kuczkowski...

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2010-04-06 10:24:45

Molecular gauge to disclose function of new medications Luminescent markers are an indispensable tool for researchers working with DNA. But the markers are troublesome. Some tend to destroy the function and structure of DNA when inserted. Others emit so little light, that they can barely be detected in the hereditary material. So researchers have been asking for alternative markers.Now a PhD student at Department of Chemistry at the University of Copenhagen has developed a tool in...

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2010-03-08 15:05:00

One of the biggest questions facing scientists today is how life began. How did non-living molecules come together in that primordial ooze to form the polymers of life? Scientists at the Georgia Institute of Technology have discovered that small molecules could have acted as "molecular midwives" in helping the building blocks of life's genetic material form long chains and may have assisted in selecting the base pairs of the DNA double helix. The research appears in the online early edition...

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2008-03-06 13:30:00

A team of bioinformaticians at the Universit© de Montr©al (UdeM) report in the March 6th edition of Nature the discovery of a structural alphabet that can be used to infer the 3D structure of ribonucleic acid (RNA) from sequence data, providing new tools to understand the role of this important class of cellular regulators. The folding of a single-stranded RNA molecule is determined by the interactions between its constituent nucleotides. The classical approach to RNA modeling...

2005-10-26 14:41:37

Researchers at Stanford University have created a larger-than-normal DNA molecule that is copied almost as efficiently as natural DNA. The findings, reported in the Oct. 25 online edition of the Proceedings of the National Academy of Sciences (PNAS), may reveal new insights into how genetic mutations-tiny mistakes that occur during DNA replication-arise. The discovery was made in the laboratory of Eric Kool, a professor of chemistry at Stanford and co-author of the PNAS study. DNA, the...

2005-10-03 14:59:57

PITTSBURGH--For the first time, a team of investigators at Carnegie Mellon University has shown that the binding of metal ions can mediate the formation of peptide nucleic acid (PNA) duplexes from single strands of PNA that are only partly complementary. This result opens new opportunities to create functional, three-dimensional nanosize structures such as molecular-scale electronic circuits, which could reduce by thousands of times the size of today's common electronic devices. The research...

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2005-08-29 13:28:42

Astrobiology Magazine -- Chemists at Ohio State University have gained new insight into how sunlight affects DNA. And what they found overturns ideas about genetic mutation that originated decades ago. In the current issue of the journal Nature, Bern Kohler and his colleagues report that DNA dissipates the energy from ultraviolet (UV) radiation in a kind of energy wave that travels up the edge of the DNA molecule, as if the energy were climbing one side of the helical DNA "ladder." The...

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2005-08-24 16:55:00

COLUMBUS , Ohio -- Chemists at Ohio State University have gained new insight into how sunlight affects DNA. And what they found overturns ideas about genetic mutation that originated decades ago. In the current issue of the journal Nature, Bern Kohler and his colleagues report that DNA dissipates the energy from ultraviolet (UV) radiation in a kind of energy wave that travels up the edge of the DNA molecule, as if the energy were climbing one side of the helical DNA "ladder." The finding...


Word of the Day
malpais
  • The ragged surface of a lava-flow.
'Malpais' translates from Spanish as 'bad land.'