Latest Bcl-2-associated X protein Stories
Scientists at the Walter and Eliza Hall Institute have for the first time visualized the molecular changes in a critical cell death protein that force cells to die. The finding provides important insights into how cell death occurs, and could lead to new classes of medicines that control whether diseased cells live or die. Cell death, called apoptosis, is important for controlling the number of cells in the body. Defects in cell death have been linked to the development of diseases such...
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Embryonic stem cells — those revered cells that give rise to every cell type in the body — just got another badge of honor. If they suffer damage that makes them a threat to the developing embryo, they swiftly fall on their swords for the greater good, according to a study published online May 3, 2012 in the journal Molecular Cell. The finding offers a new glimpse into the private lives of stem cells that could help scientists use them to grow new neurons or other cells to replace...
Researchers report they have figured out how the cancer-causing bacterium Helicobacter pylori attacks a cell's energy infrastructure, sparking a series of events in the cell that ultimately lead it to self-destruct. H. pylori are the only bacteria known to survive in the human stomach. Infection with H. pylori is associated with an increased risk of gastric cancer, the second-leading cause of cancer-related deaths worldwide. "More than half the world's population is currently infected...
New research led by UC Davis scientists provides insight into why some body organs are more susceptible to cell death than others and could eventually lead to advances in treating or preventing heart attack or stroke.In a paper published Jan. 21 in the journal Molecular Cell, the UC Davis team and their collaborators at the National Institutes of Health and Johns Hopkins University report that Bax, a factor known to promote cell death, is also involved in regulating the behavior of...
A recent study undertaken by investigators at five research centres, amongst which is the CSIC-University of the Basque Country Biophysics Unit, provides new clues for the understanding of the "˜cell suicide' process. The research was published in the latest issue of the prestigious Cell journal.Our bodies daily eliminate in a controlled manner more than 100 million defective cells, by means of a procedure known as "˜cell suicide' or apoptosis. This is a highly complicated process, any...
Walter and Eliza Hall Institute scientists have identified a key step in the biological process of programmed cell death, also called apoptosis.Apoptosis is important in human biology as it removes unwanted and sometimes dangerous cells from our bodies, protecting us against cancer development. It can also, however, lead to the development of degenerative diseases when healthy cells are errantly destroyed.The research, led by Dr Ruth Kluck from the institute's Molecular Genetics of Cancer...
Two different anti-apoptotic proteins support cancer cell survival via an identical mechanism, yet differ in their sensitivity to chemotherapeutic drugs, report Brunelle et al. The study will be published online October 26, 2009 and in the November 2, 2009 print issue of the Journal of Cell Biology (JCB).Cancer cells often become dependent on one or more anti-apoptotic proteins to avoid death while continuing to proliferate. BCL-2, for example, is overexpressed in many cancers and mops up...
A research article to be published on June 21, 2009 in the World Journal of Gastroenterology addresses this question. The research team led by Professor Yan Li from Shengjing Hospital of China Medical University studied the growth inhibitory effects of Alisol B acetat and determined its mechanism of antitumor activity in human gastric cancer cell line SGC7901.Professor Li and his colleagues found that Alisol B acetat could inhibit the proliferation of SGC7901 cell in a time and dose dependent...
Looking for efficient anti-tumor drugs is a hot research area. Chrysin (5,7-dihydroxy flavone), a natural widely-distributed flavonoid, has been reported to have many different biological activities such as anti-oxidant, anti-virus, antidiabetogenic activity and clear anxiolytic effect. However, Chrysin is limited in its clinical application because of its modest absorption in the intestine and rapid in vivo glycosylation. To improve the biological activity of chrysin, a number of its...
