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Latest Bcl-2-associated X protein Stories

2013-07-11 13:07:15

St. Jude Children's Research Hospital discovers a role for a protein in research that has implications for treatment of cancer and heart disease St. Jude Children's Research Hospital scientists have discovered that a protein used by cancer cells to evade death also plays a vital role in heart health. This dual role complicates efforts to develop cancer drugs that target the protein, but may lead to new therapies for heart muscle damage. The research appeared in the June 15 edition of the...

2013-02-04 09:59:57

Scientists at the Walter and Eliza Hall Institute have for the first time visualized the molecular changes in a critical cell death protein that force cells to die. The finding provides important insights into how cell death occurs, and could lead to new classes of medicines that control whether diseased cells live or die. Cell death, called apoptosis, is important for controlling the number of cells in the body. Defects in cell death have been linked to the development of diseases such...

Stem Cells Poised To Self-Destruct For The Good Of The Embryo
2012-05-03 10:58:28

Embryonic stem cells – those revered cells that give rise to every cell type in the body – just got another badge of honor. If they suffer damage that makes them a threat to the developing embryo, they swiftly fall on their swords for the greater good, according to a study published online May 3, 2012 in the journal Molecular Cell. The finding offers a new glimpse into the private lives of stem cells that could help scientists use them to grow new neurons or other cells to...

2011-11-01 21:05:25

Researchers report they have figured out how the cancer-causing bacterium Helicobacter pylori attacks a cell's energy infrastructure, sparking a series of events in the cell that ultimately lead it to self-destruct. H. pylori are the only bacteria known to survive in the human stomach. Infection with H. pylori is associated with an increased risk of gastric cancer, the second-leading cause of cancer-related deaths worldwide. "More than half the world's population is currently infected...

2011-01-24 20:57:08

New research led by UC Davis scientists provides insight into why some body organs are more susceptible to cell death than others and could eventually lead to advances in treating or preventing heart attack or stroke. In a paper published Jan. 21 in the journal Molecular Cell, the UC Davis team and their collaborators at the National Institutes of Health and Johns Hopkins University report that Bax, a factor known to promote cell death, is also involved in regulating the behavior of...

2010-09-27 17:19:55

A recent study undertaken by investigators at five research centres, amongst which is the CSIC-University of the Basque Country Biophysics Unit, provides new clues for the understanding of the "Ëœcell suicide' process. The research was published in the latest issue of the prestigious Cell journal. Our bodies daily eliminate in a controlled manner more than 100 million defective cells, by means of a procedure known as "Ëœcell suicide' or apoptosis. This is a highly...

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2009-12-18 10:31:14

Walter and Eliza Hall Institute scientists have identified a key step in the biological process of programmed cell death, also called apoptosis. Apoptosis is important in human biology as it removes unwanted and sometimes dangerous cells from our bodies, protecting us against cancer development. It can also, however, lead to the development of degenerative diseases when healthy cells are errantly destroyed. The research, led by Dr Ruth Kluck from the institute's Molecular Genetics of Cancer...

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2009-10-26 08:41:28

Two different anti-apoptotic proteins support cancer cell survival via an identical mechanism, yet differ in their sensitivity to chemotherapeutic drugs, report Brunelle et al. The study will be published online October 26, 2009 and in the November 2, 2009 print issue of the Journal of Cell Biology (JCB). Cancer cells often become dependent on one or more anti-apoptotic proteins to avoid death while continuing to proliferate. BCL-2, for example, is overexpressed in many cancers and mops up...


Word of the Day
cacodemon
  • An evil spirit; a devil.
  • A nightmare.
  • In astrology, the twelfth house of a scheme or figure of the heavens: so called from its signifying dreadful things, such as secret enemies, great losses, imprisonment, etc.
'Cacodemon' comes from a Greek term meaning 'evil genius.'
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