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Latest Berislav Zlokovic Stories

2012-05-16 23:35:32

A well-known genetic risk factor for Alzheimer´s disease triggers a cascade of signaling that ultimately results in leaky blood vessels in the brain, allowing toxic substances to pour into brain tissue in large amounts, scientists report May 16 in the journal Nature. The results come from a team of scientists investigating why a gene called ApoE4 makes people more prone to developing Alzheimer´s. People who carry two copies of the gene have roughly eight to 10 times the risk of...

2012-05-16 22:54:11

Common variants of the ApoE gene are strongly associated with the risk of developing late-onset Alzheimer's disease, but the gene's role in the disease has been unclear. Now, researchers funded by the National Institutes of Health have found that in mice, having the most risky variant of ApoE damages the blood vessels that feed the brain. The researchers found that the high-risk variant, ApoE4, triggers an inflammatory reaction that weakens the blood-brain barrier, a network of cells and...

2009-10-20 14:59:21

A chemical cousin of a drug currently used to treat sepsis dramatically slows the progression of amyotrophic lateral sclerosis, better known as ALS or Lou Gehrig's disease, in mice. The results offer a bit of good news in efforts to develop a therapy to stop or slow the progression of a disease that generally kills its victims within just a few years. In a paper published online Oct. 19 in the Journal of Clinical Investigation, scientists studied the use of a form of an enzyme known as...

2008-12-22 09:21:47

Researchers have found that two proteins which work in tandem in the brain's blood vessels present a double whammy in Alzheimer's disease. Not only do the proteins lessen blood flow in the brain, but they also reduce the rate at which the brain is able to remove amyloid beta, the protein that builds up in toxic quantities in the brains of patients with the disease. The work, described in a paper published online Dec. 21 in the journal Nature Cell Biology, provides hard evidence directly...

2005-08-15 13:13:12

Scientists at the University of Rochester Medical Center have discovered a link between a prominent developmental gene and neurovascular dysfunction in Alzheimer's disease. The gene plays a major role in the growth and remodeling of vascular systems. But, in brain cells of people with Alzheimer's disease, expression of the gene is low, the scientists found, revealing a new piece of the Alzheimer's puzzle. In laboratory studies, the scientists also showed that restoration of the gene...


Word of the Day
jument
  • A beast of burden; also, a beast in general.
'Jument' ultimately comes from the Latin 'jugum,' yoke.
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