Latest Beta cell Stories
CAMBRIDGE, Mass., March 29, 2011 /PRNewswire/ -- Pathfinder, LLC, a private biotechnology company focused on the treatment of diseases characterized by organ-specific cell damage ("Pathfinder"), today announced publication of promising preclinical data demonstrating that the Company's unique cell-based therapy is able to completely reverse diabetes in a mouse model.
New evidence has emerged from studies in mice that short telomeres or "caps" at the ends of chromosomes may predispose people to age-related diabetes.
A pill taken once a day in the morning prevented type 2 diabetes in more than 70 percent of individuals whose obesity, ethnicity and other markers put them at highest risk for the disease.
Johns Hopkins researchers believe they have uncovered the molecular switch for the secretion of insulin â€” the hormone that regulates blood sugar â€” providing for the first time an explanation of this process.
The death of insulin-producing beta cells in the pancreas is a core defect in diabetes.
Researchers say an evolutionary gene mutation that occurred in humans millions of years ago and our subsequent inability to produce a specific kind of sialic acid molecule appears to make people more vulnerable to developing type 2 diabetes, especially if theyâ€™re overweight.
INDIANAPOLIS and NEW YORK, Feb.
About 1 million people are affected by type 1 diabetes in the United States.
Type 1 diabetes could be converted to an asymptomatic, non-insulin-dependent disorder by eliminating the actions of a specific hormone.
The research group led by professor Makoto Tominaga and Dr. Kunitoshi Uchida, National institute for Physiological Sciences (NIPS), found TRPM2 ion channel in pancreatic beta-cells is important for insulin secretion stimulated by glucose and gastrointestinal hormone (incretin) secreted after food intake.
Insulin, a hormone, is used to regulate carbohydrate and fat metabolism in the body. Insulin causes cells to take up glucose from the blood and store it as glycogen in the liver and muscle. This hormone stops the body from using fat as an energy source by inhibiting the release of glucagons. Without insulin the body fails to take glucose into the bodies cells and in turns uses fat as an energy source. It also has several other anabolic effects throughout the body. Diabetes mellitus results...
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