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Latest Beta cell Stories

2010-09-23 06:30:00

STOCKHOLM, Sept. 23 /PRNewswire/ -- Tolerx, Inc., a biopharmaceutical company developing novel therapies to treat autoimmune diseases and cancer by modulating T cell activity, today announced the presentation of preclinical research describing the mechanism of action of otelixizumab at the 46th Annual Meeting of the European Association for the Study of Diabetes (EASD). In addition, Tolerx also announced that the first European patient was enrolled in DEFEND-2, a confirmatory Phase 3...

2010-09-22 10:59:00

GORDONSVILLE, Va., Sept. 22 /PRNewswire/ -- The cellular services company Beta-Pro LLC, announced today that it donated more than 300,000 human pancreatic islet cells to nationally renowned diabetes researcher Raghavendra G. Mirmira, M.D., Ph.D., the Eli Lilly & Co. Professor of Pediatric Diabetes, Indiana University School of Medicine, Herman B. Wells Center for Pediatric Research. Dr. Mirmira and colleagues subsequently published their work in leading scientific journals, including,...

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2010-09-13 06:09:43

Scientists say that shedding light on how a malfunctioning protein helps trigger type 2 diabetes could eventually help offer the chance to stop the damage, according to BBC News. The presence of amyloid protein may help create a chain reaction that destroys vital insulin-producing cells. Researchers say that future drugs could help target this process. Amyloid is also implicated in many other diseases such as Alzheimer's. Type 2 diabetes is the most common form of the disease and it...

2010-07-28 14:34:57

With a single stimulatory molecule, human insulin-producing beta cell replication can be sustained for at least four weeks in a mouse model of diabetes, according to researchers at the University of Pittsburgh School of Medicine in Diabetes, a journal of the American Diabetes Association. They also found several cocktails of molecules that drive human beta cells to replicate, as well as important differences between mouse and human beta cells that could influence how these approaches are best...

2010-07-21 10:29:00

NEENAH, Wis., July 21 /PRNewswire/ -- A scientific journal, Phytotherapy Research (May 17, 2010), has reported findings from research teams at King's College London and at Burdwan Medical College, J. B. Ayurved College and Calcutta University (West Bengal). The conclusions confirm the earlier findings of Ayurvedic-Life that the patented Gymnema sylvestre extract, OSA(TM) (Om Santal Adivasi), stimulated insulin secretion from human islets in vitro and in vivo. They also confirmed earlier...

2010-07-13 15:21:41

Disruption of two genes that control circadian rhythms can lead to diabetes, a researcher at UT Southwestern Medical Center has found in an animal study. Mice with defective copies of the genes, called CLOCK and BMAL1, develop abnormalities in pancreatic cells that eventually render the cells unable to release sufficient amounts of insulin. "These results indicate that disruption of the daily clock may contribute to diabetes by impairing the pancreas' ability to deliver insulin," said Dr....

2010-07-02 19:59:04

The muscle weakness and coordination problems sometimes seen in patients with neonatal diabetes "“ a rare, inherited form of diabetes "“ are caused by problems in the brain rather than the muscles, according to research published today. The findings could pave the way for the development of improved treatments for the disease. Neonatal diabetes affects one in 100,000 infants in the UK. It usually begins in the first six months of a child's life and can be accompanied by...

2010-06-29 02:28:21

The cause of diabetes during pregnancy is directly controlled by serotonin, a chemical produced by the body and normally known as a neurotransmitter, and is influenced by the amount of protein in the mother's diet early in pregnancy, according to new findings of an international team led by researchers at UCSF. The surprise discovery could lead to simple dietary solutions and possible therapeutics for the disorder known as gestational diabetes, which if untreated, has serious implications for...

2010-06-28 06:00:00

CAMBRIDGE, Mass., June 28 /PRNewswire/ -- Tolerx, Inc., a biopharmaceutical company developing novel therapies to treat autoimmune diseases and cancer by modulating T cell activity, today announced the initiation of a confirmatory Phase 3 clinical trial to further evaluate otelixizumab in autoimmune new-onset type 1 diabetes. The confirmatory Phase 3 clinical trial is called DEFEND-2 (Durable-Response Therapy Evaluation For Early or New-Onset Type 1 Diabetes) and immediately follows...

2010-06-28 06:00:00

ORLANDO, Fla., June 28 /PRNewswire/ -- Tolerx, Inc., a biopharmaceutical company developing novel therapies to treat autoimmune diseases and cancer by modulating T cell activity, today presented an analysis of baseline data from the Phase 3 DEFEND-1 clinical trial of otelixizumab in patients with autoimmune new onset type 1 diabetes. The analysis showed that higher C-peptide levels had a statistically significant correlation with a decrease in two distinct measurements of glucose...


Latest Beta cell Reference Libraries

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2010-12-03 18:12:26

Insulin, a hormone, is used to regulate carbohydrate and fat metabolism in the body. Insulin causes cells to take up glucose from the blood and store it as glycogen in the liver and muscle. This hormone stops the body from using fat as an energy source by inhibiting the release of glucagons. Without insulin the body fails to take glucose into the bodies cells and in turns uses fat as an energy source. It also has several other anabolic effects throughout the body. Diabetes mellitus results...

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Word of the Day
mundungus
  • A stinking tobacco.
  • Offal; waste animal product; organic matter unfit for consumption.
This word comes from the Spanish 'mondongo,' tripe, entrails.