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Latest Beta cell Stories

2012-05-01 20:52:54

A transcription factor activated by too much sugar in the blood is a driver of an implacable cycle of too little insulin resulting in too much sugar in the blood that, in turn, causes failure of beta cells to make enough insulin which results in even higher blood sugar and type 2 diabetes, said researchers from Baylor College of Medicine in an online report in the journal Diabetologia. That transcription factor — carbohydrate response element binding protein or ChREBP — offers...

2012-04-26 12:07:31

Scientists from The Danish Stem Cell Center (DanStem) at the University of Copenhagen and Hagedorn Research Institute have gained new insight into the signaling paths that control the body´s insulin production. This is important knowledge with respect to their final goal: the conversion of stem cells into insulin-producing beta cells that can be implanted into patients who need them. The research results have just been published in the well-respected journal PNAS. Insulin is a hormone...

Scientists Uncover Novel Gene's Key Role In Type 2 Diabetes
2012-04-10 03:32:06

Using computational methods, Stanford University School of Medicine investigators have strongly implicated a novel gene in the triggering of type-2 diabetes. Their experiments in lab mice and in human blood and tissue samples further showed that this gene not only is associated with the disease, as predicted computationally, but is also likely to play a major causal role. In a study published online April 9 in Proceedings of the National Academy of Sciences, the researchers combed through...

2012-04-09 13:29:21

Insulin is required for the regulation of blood sugar levels. In type I diabetes, the cells that produce insulin are destroyed by the immune system. Chantal Mathieu and colleagues at the University of Leuven have attempted to circumvent this response by taking advantage of the fact that the immune system accepts foreign gut bacteria. The Mathieu group engineered gut bacteria so that they produce a form of insulin, and asked if these bacteria could retrain the immune system in mice with type I...

2012-04-04 14:17:18

Three-dimensional clusters of pancreatic beta-cells that live much longer and secrete more insulin than single cells grown in the laboratory are valuable new tools for studying pancreatic diseases such as diabetes and for testing novel therapies. This cutting-edge advance is described in an article in Tissue Engineering, Part C, Methods, a peer-reviewed journal from Mary Ann Liebert, Inc.. The article is available free online at the Tissue Engineering website. "Finding a solution for the...

2012-03-28 01:07:21

A number of studies have shown that excess insulin circulating in the bloodstream is a major independent risk factor for cardiovascular disease. However, a new study from Joslin Diabetes Center finds that this condition, called hyperinsulinemia, is itself not a cause of atherosclerosis. In humans, insulin resistance, a condition in which insulin becomes less effective at lowering blood sugar levels, coexists with hyperinsulinemia. Both are associated with atherosclerosis, the buildup of...

2012-03-23 09:41:10

Study provides important clue in type 1 diabetes; could help scientists identify and validate potential drug targets to alleviate ER stress and preserve beta cell mass in T1D In type 1 diabetes (T1D), pancreatic beta cells die from a misguided autoimmune attack, but how and why that happens is still unclear. Now, JDRF-funded scientists from the Indiana University School of Medicine have found that a specific type of cellular stress takes place in pancreatic beta cells before the onset of...

2012-03-16 23:59:25

Researchers at the University of Pittsburgh School of Medicine have identified a cell-signaling pathway that plays a key role in increasing insulin secretion during pregnancy and, when blocked, leads to the development of gestational diabetes. Their findings are available online today in Diabetes, one of the journals of the American Diabetes Association. During pregnancy, pancreatic beta cells should expand and produce more insulin to adapt to the needs of the growing baby, explained...

Glucose level blood test
2012-03-13 08:12:43

Columbia researchers have conducted a study that suggests cells inside intestines could be employed to make insulin for patients with type I diabetes. Previously, researchers considered stem cell transplants to be the only way to replace lost cells inpatients with type I diabetes. Such a discovery could also mean that these patients would be free from daily insulin injections as well. Researchers have been conducting their work on mice and published their results in the journal Nature...


Latest Beta cell Reference Libraries

0_0d961f30bdfa64859d9b869b063ddcd2
2010-12-03 18:12:26

Insulin, a hormone, is used to regulate carbohydrate and fat metabolism in the body. Insulin causes cells to take up glucose from the blood and store it as glycogen in the liver and muscle. This hormone stops the body from using fat as an energy source by inhibiting the release of glucagons. Without insulin the body fails to take glucose into the bodies cells and in turns uses fat as an energy source. It also has several other anabolic effects throughout the body. Diabetes mellitus results...

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Word of the Day
mallemaroking
  • Nautical, the visiting and carousing of sailors in the Greenland ships.
This word is apparently from a confusion of two similar Dutch words: 'mallemerok,' a foolish woman, and 'mallemok,' a name for some persons among the crew of a whaling vessel.