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Latest Beta secretase Stories

2012-02-20 12:56:23

Drugs may act like bad electrician, messing up wiring in brain and nervous system Alzheimer's disease drugs now being tested in clinical trials may have potentially adverse side effects, according to new Northwestern Medicine research. A study with mice suggests the drugs could act like a bad electrician, causing neurons to be miswired and interfering with their ability to send messages to the brain. The findings, from the scientist whose original research led to the drug development,...

2012-02-14 11:46:28

Curcumin, a substance extracted from turmeric, prolongs life and enhances activity of fruit flies with a nervous disorder similar to Alzheimers. The study conducted at Linköping University, indicates that it is the initial stages of fibril formation and fragments of the amyloid fibrils that are most toxic to neurons. Ina Caesar, as the lead author, has published the results of the study in the prestigious journal PLoS One. For several years curcumin has been studied as a...

2012-01-25 13:05:57

Pilot study suggests infrared analysis of white blood cells is a promising strategy for diagnosis of Alzheimer's disease Spanish researchers, led by Pedro Carmona from the Instituto de Estructura de la Materia in Madrid, have uncovered a new promising way to diagnose Alzheimer's disease more accurately. Their technique, which is non-invasive, fast and low-cost, measures how much infrared radiation is either emitted or absorbed by white blood cells. Because of its high sensitivity, this...

2011-12-02 01:13:30

A diametric shift in the levels of two proteins involved in folding, moving and cutting other proteins enables accumulation of the destructive brain plaque found in Alzheimer's disease, researchers report. VPS35 is a protein that folds others into specific positions to unleash their functions. When levels are reduced as they are in aging, it unleashes the normally dormant BACE1, a protein responsible for beta amyloid plaque production, Georgia Health Sciences University researchers report...

2011-11-21 22:54:41

Sluggish recycling of a protein-slicing enzyme could promote Alzheimer's disease, according to a study published online on November 21 in The Journal of Cell Biology (www.jcb.org). Abeta, the toxic protein that accumulates in the brains of Alzheimer's patients, is formed when enzymes cut up its parental protein, known as amyloid precursor protein. One of those enzymes is beta-secretase or BACE1. BACE1 cycles between the Golgi apparatus and the plasma membrane, traveling through endosomes...

2011-09-06 22:32:12

JDRF-funded scientists collaborate with pharmaceutical company to uncover new ways to stimulate pancreatic beta cell growth One of the holy grails in diabetes research is to discover molecules that stimulate beta cell growth and to find drugs that target these molecules. Now, JDRF-funded researchers in collaboration with the pharmaceutical company Hoffmann-La Roche, have done both, discovering not only a protein that regulates beta cell growth, but also a chemical compound that stimulates...

2011-07-18 05:30:00

CAMBRIDGE, Mass., July 18, 2011 /PRNewswire/ -- Satori(TM) Pharmaceuticals today announced the presentation of two posters at the Alzheimer's Association International Conference on Alzheimer's Disease (ICAD) taking place in Paris, France, July 16-21, 2011. Both posters illuminate the unique biological activity associated with Satori's approach to the treatment of Alzheimer's disease. The posters were titled, "Gamma-secretase modulators do not show a potency shift in high expressing model...

2011-05-31 21:15:59

Researchers at the University of California, San Diego, the Medical University of South Carolina and American Life Science Pharmaceuticals of San Diego have demonstrated that oral administration of a cysteine protease inhibitor, E64d, not only reduces the build-up of ÃŽ²-amyloid (AÃŽ²) in the brains of animal models for Alzheimer's disease, but also results in a substantial improvement in memory deficit. A paper detailing the findings has been published as an...

2011-04-13 21:52:53

Compounds helped nerve extensions re-grow faster in mouse studies Drugs already in development to treat Alzheimer's disease may eventually be tapped for a different purpose altogether: re-growing the ends of injured nerves to relieve pain and paralysis. According to a new Johns Hopkins study, experimental compounds originally designed to combat a protein that builds up in Alzheimer's-addled brains appear to make crushed or cut nerve endings grow back significantly faster, a potential boon for...

2011-02-10 08:28:09

(Ivanhoe Newswire) -- Like two brothers wrestling fighting who need to be put in separate corners, a pair of protein molecules work together to speed up the toxic events of Alzheimer's disease. The second molecule was identified and could lead to novel drugs that slow or even prevent the disease. Alzheimer's disease is an irreversible, progressive brain disease marked by deterioration of nerve cells and eventual complete loss of cognitive functioning "“ thinking, memory, and reason....


Word of the Day
call-note
  • The call or cry of a bird or other animal to its mate or its young.
'Call-note' is newer than 'bird-call,' which originally referred to 'an instrument for imitating the note of birds' but now also refers to 'the song or cry of a bird.'
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