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Latest Biochemistry of Alzheimer's disease Stories

2013-07-26 14:12:08

Study first to use 'structural' approach in hunt for amyloid-inhibiting agents UCLA chemists and molecular biologists have for the first time used a "structure-based" approach to drug design to identify compounds with the potential to delay or treat Alzheimer's disease, and possibly Parkinson's, Lou Gehrig's disease and other degenerative disorders. All of these diseases are marked by harmful, elongated, rope-like structures known as amyloid fibrils, linked protein molecules that form...

Researchers Quantify Brain Protein Changes In Alzheimer Patients
2013-06-13 08:30:44

April Flowers for redOrbit.com - Your Universe Online A significant and potentially pivotal difference between the brains of patients with an inherited form of Alzheimer's disease and healthy family members who do not have it has been measured by researchers at Washington University School of Medicine in St. Louis. Researchers have long known that a protein fragment called amyloid beta builds up into plaques in Alzheimer´s patient´s brains. The theory is that these plaques...

Researchers Find Alzheimer’s Biomarkers
2013-05-01 14:21:32

Brett Smith for redOrbit.com - Your Universe Online Researchers from Australia´s Commonwealth Scientific and Industrial Research Organisation“¯(CSIRO) are reporting significant progress in developing a blood test that can predict the onset of Alzheimer´s in an individual. According to their report in the journal Molecular Psychiatry, the researchers said they have identified several biomarkers that are associated with the toxic build-up of beta amyloid, a brain...

2013-03-20 15:45:19

The Journal of Neuroscience has published a study led by researchers at the Max Planck Florida Institute for Neuroscience, the first and only U.S. extension of the prestigious Max Planck Society, that may hold a stunning breakthrough in the fight to treat Alzheimer's disease. The study potentially identifies a cause of Alzheimer's disease–based on a newly-discovered signaling pathway in cellular models of Alzheimer's disease–and opens the door for new treatments by successfully...

2012-07-02 21:37:07

Research published today in Biomed Central's open access journal Journal of Neuroinflammation suggests that chronic inflammation can predispose the brain to develop Alzheimer's disease. To date it has been difficult to pin down the role of inflammation in Alzheimer's disease (AD), especially because trials of NSAIDs appeared to have conflicting results. Although the ADAPT (The Alzheimer`s Disease Anti-inflammatory Prevention Trial) trial was stopped early, recent results suggest that...

Alzheimer's Infects Neuron To Neuron
2012-06-27 09:51:55

The inexorable spread of Alzheimer's disease through the brain leaves dead neurons and forgotten thoughts in its wake. Researchers at Linköping University in Sweden are the first to show how toxic proteins are transferred from neuron to neuron. Through experiments on stained neurons, the research team — under the leadership of Martin Hallbeck, associate professor of Pathology — has been able to depict the process of neurons being invaded by diseased proteins that...

2012-06-13 13:06:48

Researchers from Boston University School of Medicine (BUSM) have identified a novel group of proteins that accumulate in the brains of patients with Alzheimer's disease. These findings, which appear online in the Journal of Neuroscience, may open up novel approaches to diagnose and stage the progression likelihood of the disease in Alzheimer patients. Alzheimer's disease is presumed to be caused by the accumulation of β-amyloid, which then induces aggregation of a neuronal protein,...

2012-06-11 21:35:48

Studies show a naturally occurring protein called beta amyloid may be the key to diagnosis and could even be the answer to treating the neurodegenerative disease An arsenal of Alzheimer's research revealed at the Society of Nuclear Medicine's 59th Annual Meeting indicates that beta-amyloid plaque in the brain not only is involved in the pathology of Alzheimer's disease but may also precede even mild cognitive decline. These and other studies advance molecular imaging for the early...

2012-05-23 17:01:47

Pathological aging (PA) is used to describe the brains of people which have Alzheimer's disease (AD)-like pathology but where the person showed no signs of cognitive impairment whilst they were alive. New research, published in BioMed Central's open access journal Alzheimer's Research & Therapy, shows that PA and AD brains contain similar amyloid β (Aβ) plaques and that while on average AD brains contain more Aβ there was considerable overlap in Aβ subtypes. These...


Word of the Day
sough
  • A murmuring sound; a rushing or whistling sound, like that of the wind; a deep sigh.
  • A gentle breeze; a waft; a breath.
  • Any rumor that engages general attention.
  • A cant or whining mode of speaking, especially in preaching or praying; the chant or recitative characteristic of the old Presbyterians in Scotland.
  • To make a rushing, whistling, or sighing sound; emit a hollow murmur; murmur or sigh like the wind.
  • To breathe in or as in sleep.
  • To utter in a whining or monotonous tone.
According to the OED, from the 16th century, this word is 'almost exclusively Scots and northern dialect until adopted in general literary use in the 19th.'
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