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Latest Biochemistry of Alzheimer's disease Stories

2009-09-25 05:34:14

Chronic sleep deprivation in a mouse model of Alzheimer's disease makes Alzheimer's brain plaques appear earlier and more often, researchers at Washington University School of Medicine in St. Louis report online this week in Science Express. They also found that orexin, a protein that helps regulate the sleep cycle, appears to be directly involved in the increase. Neurodegenerative disorders like Alzheimer's disease and Parkinson's disease often disrupt sleep. The new findings are some of the...

2009-09-24 09:34:34

Researchers from the Memory and Cognition Center at University Hospitals Case Medical Center will begin testing an intriguing new approach to slowing down the progression of Alzheimer's Disease (AD) using Intravenous Immune Globulin (IGIV), also known as gammaglobulin. IGIV is traditionally used to treat primary immunodeficiency disorders, but is not currently approved for treating AD, which is one of the leading causes of dementia in the elderly. Initial research in experimental models and...

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2009-08-10 12:55:00

Co-authors Alex Crowe, Research Specialist; Kurt R. Brunden, PhD, Director of Drug Discovery at Penn's Center for Neurodegenerative Disease Research (CNDR); Virginia M.-Y. Lee, PhD, and John Q. Trojanowski, MD, PhD, CNDR Co-Directors, and colleagues conducted the screen to find small molecules that prevent the formation of the tau protein fibrils. These fibrils, a hallmark pathological feature of AD, have been a holy grail for investigators hoping to better treat AD and related...

2009-07-29 14:33:14

New research has uncovered an early disruption in the process of memory formation in older humans who exhibit some early brain changes associated with Alzheimer's disease (AD) but show little or no memory impairment. The work, published by Cell Press in the July 30th issue of the journal Neuron, sheds light on the role of amyloid protein in memory impairment and may lead to development of strategies for predicting and treating cognitive decline in individuals who are at-risk for AD.Amyloid...

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2009-06-08 11:15:00

New research has shown that a rogue protein thought to cause Alzheimer's can spread through the brain, turning healthy tissue bad, BBC News reported.The tau protein may share characteristics with the prion proteins that cause vCJD. Scientists found it triggered formation of protein tangles linked to Alzheimer's after they injected it into the brains of healthy mice.But the study, published in the Nature Cell Biology, said this did not mean tau could be passed from person to person.Tau is a...

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2009-04-16 09:11:09

U.S. scientists say they've resolved a dispute about one of the mechanisms believed responsible for brain cell death and memory loss in Alzheimer's disease. Assistant Professors Michael Mayer of the University of Michigan and Jerry Yang of the University of California-San Diego said they and their colleagues have clarified how small proteins called amyloid-beta peptides damage brain cell membranes, allowing extra calcium ions to enter the neurons. The researchers confirmed evidence that...

2009-03-18 09:04:48

Researchers at the University of Illinois at Chicago College of Medicine have discovered a mode of action for mysterious but diagnostic protein snarls found in the brains of Alzheimer's patients that suggests a one-two punch of therapy may be needed to combat the neurodegenerative disease.Alzheimer's disease, which may affect as many as 5 million Americans and is among the most costly diseases to society in the United States and Europe, is characterized by two distinctive protein...

2009-03-17 19:31:19

Alzheimer's patients who have diabetes and elevated levels of cholesterol experience faster cognitive decline, U.S. researchers said. These findings indicate that controlling vascular conditions may be one way to delay the course of Alzheimer's, which would be a major development in the treatment of this devastating disease as currently there are few treatments available to slow its progression, senior author Yaakov Stern of the Columbia University Medical Center, and senior author of the...

2009-02-25 06:00:00

ROCKVILLE, Md., Feb. 25 /PRNewswire-USNewswire/ -- Adlyfe, a private company developing novel biomarkers and diagnostic tests for amyloid diseases, announced today that it has signed an agreement with Wyeth Pharmaceuticals, a division of Wyeth, to develop biomarker assays designed to measure levels of beta amyloid in the human brain. The companies will develop assays for specific beta amyloid targets for use in facilitating the development of treatments for Alzheimer's disease. The multiyear...

2009-02-20 12:59:38

A study from the Buck Institute for Age Research offers a revolutionary new model for Alzheimer's disease (AD), a devastating neurodegenerative disorder which afflicts 24 million people worldwide. In an effort to unravel the normal function of a protein implicated in AD, scientists in California and France have discovered a naturally occurring protein that provides a new therapeutic target for the disease. The finding upsets the current theory that AD is a disease of toxicity stemming from...


Word of the Day
malpais
  • The ragged surface of a lava-flow.
'Malpais' translates from Spanish as 'bad land.'