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Latest Biochemistry of Alzheimer's disease Stories

2009-02-19 15:17:58

U.S. researchers have discovered a new route through which Alzheimer's disease may either trigger or maintain the destruction of brain cells. A team of scientists at the biotechnology firm Genentech Inc., discovered that beta-amyloid precursor protein, known as APP, and death receptor 6 trigger a widespread self destruction program that relies on caspases -- sometimes called executioner proteins because of the role they play in apoptosis, or programmed cell death, Medical News Today...

2008-12-22 09:21:47

Researchers have found that two proteins which work in tandem in the brain's blood vessels present a double whammy in Alzheimer's disease. Not only do the proteins lessen blood flow in the brain, but they also reduce the rate at which the brain is able to remove amyloid beta, the protein that builds up in toxic quantities in the brains of patients with the disease. The work, described in a paper published online Dec. 21 in the journal Nature Cell Biology, provides hard evidence directly...

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2008-11-30 07:20:00

A Swedish researcher said on Friday that mice who were fed junk food for nine months showed signs of developing the abnormal brain tangles strongly associated with Alzheimer's disease. A series of published papers by a researcher at Sweden's Karolinska Institute showed how a diet rich in fat, sugar and cholesterol could increase the risk of the most common type of dementia. "On examining the brains of these mice, we found a chemical change not unlike that found in the Alzheimer brain,"...

2008-11-25 17:36:47

A commonly used anesthetic can produce changes associated with Alzheimer's disease in the brains of living mammals, U.S. researchers said. Massachusetts General Hospital investigators in Boston show how administration of the gas isoflurane can lead to generation of the toxic amyloid-beta protein -- associated with Alzheimer's disease -- in the brains of mice. These are the first results indicating that isoflurane can set off a time-dependent cascade inducing cell death and enhanced levels of...

2008-11-19 15:11:50

Red wine may be beneficial not only for cardiovascular health, but it may also help guard against Alzheimer's disease, U.S. researchers said. Researchers at the University of California, Los Angeles, in collaboration with the Mt. Sinai School of Medicine in New York said they have discovered how red wine may reduce the incidence of Alzheimer's. The study, published in the Journal of Biological Chemistry, showed how naturally occurring compounds in red wine -- polyphenols -- blocked the...

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2008-11-16 12:00:00

A new finding suggests older adults with fewer fiber-like tangles of a protein linked with Alzheimer's stay sharper throughout life than those who age normally. "This new finding in super aged brains is very exciting," said Changiz Geula, principal investigator of the study and a research professor of neurology at the Cognitive Neurology and Alzheimer's Disease Center at Northwestern's Feinberg School. "Super-aged," means those people who maintain sharp cognitive skills in advanced age rather...

2008-11-13 18:00:24

Greater education may help buffer against amyloid plaques and other brain pathology linked to Alzheimer's disease, U.S. researchers said. Scientists at the Alzheimer's Disease Research Center at Washington University School of Medicine in St. Louis found some study participants whose brain scans revealed brain plaques -- deposits of protein that have been linked to Alzheimer's disease -- still performed well on tests of their cognitive ability. Those doing well on the tests were likely to...

2008-11-12 18:00:21

U.S. researchers have developed an imaging agent that may aid in early Alzheimer's disease diagnosis. Study authors Dr.William Klunk and Chester Mathis, along with colleagues at the University of Pittsburgh, said Pittsburgh Compound B, an imaging agent, could facilitate the early diagnosis of Alzheimer's disease, and has been used to identify amyloid deposition -- proteins believed to destroy brain cells in Alzheimer's patients -- in the brains of clinically older adults. In the study,...

2008-10-30 00:00:15

Neurological markers for Alzheimer's disease are exacerbated in brains of mice fed a diet rich in animal fat and poor in omega-3, Canadian researchers say. A University of Laval research team led by Frederic Calon used a type of transgenic mice that produce two proteins found in the brains of Alzheimer patients -- tau proteins -- which prevent proper neuron functioning, and amyloid-beta, associated with the formation of senile plaques within the brains of afflicted patients. The...

2008-10-21 12:00:33

CLARKSBURG, Md., Oct. 21 /PRNewswire/ -- An independent team of scientists is leading Alzheimer's disease research in a new, promising direction. Through a $1 million grant they received last year from Alzheimer's Disease Research, a program of the American Health Assistance Foundation (AHAF), Donald F. Weaver, M.D., Ph.D. and his colleagues at Dalhousie University in Halifax, Nova Scotia, Canada are leading a multi-site, multidisciplinary international effort to design a drug that might one...


Word of the Day
endocarp
  • The hard inner (usually woody) layer of the pericarp of some fruits (as peaches or plums or cherries or olives) that contains the seed.
This word comes from the Greek 'endon,' in, within, plus the Greek 'karpos', fruit.
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