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Latest Biochemistry of Alzheimer's disease Stories

2012-05-02 21:03:18

A highly toxic beta-amyloid — a protein that exists in the brains of Alzheimer's disease victims — has been found to greatly increase the toxicity of other more common and less toxic beta-amyloids, serving as a possible "trigger" for the advent and development of Alzheimer's, researchers at the University of Virginia and German biotech company Probiodrug have discovered. The finding, reported in the May 2 online edition of the journal Nature, could lead to more effective...

2012-05-01 09:39:38

UC Davis researchers have found novel compounds that disrupt the formation of amyloid, the clumps of protein in the brains of people with Alzheimer's disease believed to be important in causing the disease's characteristic mental decline. The so-called "spin-labeled fluorene compounds" are an important new target for researchers and physicians focused on diagnosing, treating and studying the disease. The study, published today in the online journal PLoS ONE, is entitled "The influence of...

2012-04-20 12:42:15

Multiple disease-related changes progress in parallel through distinct stages Studying a mouse model of Alzheimer's disease, neuroscientists at the Technische Universitaet Muenchen have observed correlations between increases in both soluble and plaque-forming beta-amyloid — a protein implicated in the disease process — and dysfunctional developments on several levels: individual cortical neurons, neuronal circuits, sensory cognition, and behavior. Their results, published in...

2012-04-10 13:50:29

According to new study published in the Journal of Alzheimer's Disease Alzheimer's disease (AD) is now the sixth leading cause of death among Americans, affecting nearly 1 in 8 people over the age of 65. There is currently no treatment that alters the course of this disease. However, an increasing amount of evidence suggests that changes in the way the body handles iron and other metals like copper and zinc may start years before the onset of AD symptoms. A new study shows that reducing...

2012-04-10 12:25:54

According to new study published in the Journal of Alzheimer´s Disease Alzheimer´s disease (AD) is now the sixth leading cause of death among Americans, affecting nearly 1 in 8 people over the age of 65. There is currently no treatment that alters the course of this disease. However, an increasing amount of evidence suggests that changes in the way the body handles iron and other metals like copper and zinc may start years before the onset of AD symptoms. A new study shows that...

2012-03-30 12:57:54

The deposition of amyloid beta in the brain of individuals with Alzheimer's disease is the focus of much research into both its cause and treatment. While there may not be a consensus as to whether the deposition contributes to the disease or is a consequence of the disease, there is agreement that it is not favored thermodynamically, meaning that something else is promoting the process. Other proteins are often co-deposited in vivo with amyloid beta and one such protein is serum...

2012-03-28 00:00:17

Data supports links between AD and diabetes, according to new study in the Journal of Alzheimer's Disease Alzheimer's disease is the sixth leading cause of death in the United States and the only cause of death among the top 10 in America without a way to prevent, cure or even slow its progression, according to the Alzheimer's Association. Today, 5.4 million Americans are living with the disease, and another American develops it every 69 seconds. Unfortunately, many Alzheimer's disease...

2012-03-27 13:51:47

A meta-analysis of previously published studies found that the ratio of blood plasma amyloid-β (Aβ) peptides Aβ42:Aβ40 was significantly associated with development of Alzheimer disease and dementia, according to a report published Online First by Archives of Neurology, one of the JAMA/Archives journals. "Plasma levels of amyloid-β (Aβ) peptides have been a principal focus of the growing literature on blood-based biomarkers, but studies to date have varied in...

2012-03-24 04:41:53

An international team of researchers have developed a new method for measurement of aggregated beta-amyloid — a protein complex believed to cause major nerve cell damage and dysfunction in Alzheimer's disease. The new method might facilitate diagnosis and detection as well as development of drugs directed against aggregated beta-amyloid. Alzheimer's disease (AD) is the most common cause of memory decline and dementia. According to the Alzheimer World Report 2011, today around 36...

2012-03-07 11:15:03

Antibodies that block the process of synapse disintegration in Alzheimer's disease have been identified, raising hopes for a treatment to combat early cognitive decline in the disease. Alzheimer's disease is characterized by abnormal deposits in the brain of the protein Amyloid-ß, which induces the loss of connections between neurons, called synapses. Now, scientists at UCL have discovered that specific antibodies that block the function of a related protein, called Dkk1,...


Word of the Day
snash
  • To talk saucily.
  • Insolent, opprobrious language; impertinent abuse.
This word is Scots in origin and probably imitative.